Conclusions
Gene expression profiling provides a completely new approach to rheumatology research. As an interdisciplinary technology, it has stimulated fruitful collaboration between experts in array technology, bioinformatics, immunology and rheumatology. The molecular overview given by genome-wide profiles has revealed that many problems arise and demand systematic and structured generation of expression data. This helps to dissect the complexity of cellular mixtures in clinical samples and may also contribute to identify functional components to enable comprehensive interpretation of profiles from each patient individually. This will provide a deeper understanding in the molecular mechanisms of rheumatic diseases and advance our effort in an optimised and individualised antirheumatic therapy.
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Häupl, T., Grützkau, A., Grün, J., Radbruch, A., Burmester, G. (2006). Expression analysis of rheumatic diseases, prospects and problems. In: Holmdahl, R. (eds) The Hereditary Basis of Rheumatic Diseases. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7419-5_9
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