Skip to main content
SpringerLink
Log in

Neuropeptide Y and the cerebral circulation

  • Chapter
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

Part of the book series: Experientia Supplementum ((EXS,volume 95))

Concluding remarks

The presence of NPY receptors on both endothelial and vascular smooth muscle cells indicates that blood-borne NPY as well as NPY stemming from surrounding nerves can affect contractile responses of cerebral vessels. In addition, endothelial cells may themselves be a source of NPY as well as a site of NPY metabolism. Understanding the roles of NPY in cerebrovascular regulation is complicated by multiple receptor subtypes, signalling pathways and cellular responses. Vasodilatory effects and vascular remodeling actions underscore the fact that NPY cannot just be classified as a potent vasoconstrictor. NPY is an important sympathetic transmitter, but it clearly acts via intracerebral nerves as well to regulate local CBF.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Edvinsson L, Emson P, McCulloch J, Tatemoto K, Uddman R (1983) Neuropeptide Y: Cerebrovascular innervation and vasomotor effects in the cat. Neurosci Lett 43: 79–84

    Article  CAS  PubMed  Google Scholar 

  2. Edvinsson L, Copeland J, Emson PC, McCulloch J, Uddman R (1987) Nerve fibres containing neuropeptide Y in the cerebrovascular bed: Immunocytochemistry, radioimmunoassay and vasomotor effects. J Cereb Blood Flow Metab 7: 45–57

    CAS  PubMed  Google Scholar 

  3. Cunha e Sá M, Pinto Barroso C, Castro Caldas M, Edvinsson, L, Gulbenkian S (1997) Innervation pattern of malformative cortical vessels in Sturge-Weber disease: A histochemical, immunohistochemical and ultrastructural study. Neurosurgery 41: 872–877

    Google Scholar 

  4. Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50: 143–150

    CAS  PubMed  Google Scholar 

  5. Franco-Cereceda A, Liska J (1998) Neuropeptide Y Y1 receptors in vascular pharmacology. Eur J Pharmacol 349: 1–14

    Article  CAS  PubMed  Google Scholar 

  6. Abounader R, Elhusseiny A, Cohen Z, Olivier A, Stanimirovic D, Quirion R, Hamel E (1999) Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture. J Cereb Blood Flow Metab 19: 155–163

    CAS  PubMed  Google Scholar 

  7. Nilsson T, Cantera L, Edvinsson L (1996) Presence of neuropeptide Y Y1 receptor mediating vasoconstriction in human cerebral arteries. Neurosci Lett 204: 145–148

    Article  CAS  PubMed  Google Scholar 

  8. Bao L, Kopp J, Zhang X, Xu ZQ, Zhang LF, Wong H, Walsh J, Hökfelt T (1997) Localization of neuropeptide Y Y1 receptors in cerebral blood vessels. Proc Natl Acad Sci USA 94: 12661–12666

    CAS  PubMed  Google Scholar 

  9. Abounader R, Villemure JG, Hamel E (1995) Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226. Br J Pharmacol 116: 2245–2250

    CAS  PubMed  Google Scholar 

  10. Dacey RG, Bassett JE and Takayasu M (1988) Vasomotor responses of rat intracerebral arterioles to vasoactive intestinal peptide, substance P, neuropeptide Y, and bradykinin. J Cereb Blood Flow Metab 8: 254–261

    CAS  PubMed  Google Scholar 

  11. Edvinsson L (1985) Characterization of the contractile effect of neuropeptide Y in feline cerebral arteries. Acta Physiol Scand 125: 33–41

    CAS  PubMed  Google Scholar 

  12. Edvinsson L, McCulloch J, Uddman R (1982) Feline cerebral veins and arteries: Comparison of autonomic innervation and vasomotor responses. J Physiol 325: 161–173

    CAS  PubMed  Google Scholar 

  13. Fallgren B, Arlock P, Jansen I, Edvinsson L (1990) Neuropeptide Y in cerebrovascular function: Comparison of membrane potential changes and vasomotor responses evoked by NPY and other vasoconstrictors in the guinea pig basilar artery. Neurosci Lett 114: 117–122

    Article  CAS  PubMed  Google Scholar 

  14. Tanaka Y, Nakazawa T, Ishiro H, Saito M, Uneyama H, Iwata S, Ishii K, Nakayama K (1995) Ca2+ handling mechanisms underlying neuropeptide Y-induced contraction in canine basilar artery. Eur J Pharmacol 289: 59–66

    CAS  PubMed  Google Scholar 

  15. Fredholm BB, Jansen I, Edvinsson L (1985) Neuropeptide Y is a potent inhibitor of cyclic AMP accumulation in feline cerebral blood vessels. Acta Physiol Scand 124: 467–469

    CAS  PubMed  Google Scholar 

  16. Nilsson T, You J, Sun X, Hedner T, Edvinsson L (1996) Characterization of neuropeptide Y receptors mediating contraction, potentiation and inhibition of relaxation. Blood Pressure 5: 164–169

    CAS  PubMed  Google Scholar 

  17. You J, Edvinsson L, Bryan RM Jr, (2001) Neuropeptide Y (NPY)-mediated constriction and dilation in rat middle cerebral arteries. J Cereb Blood Flow Metab 21: 77–84

    CAS  PubMed  Google Scholar 

  18. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Yamawaki T, Takeda H, Matsuoka S (1993) Transient cerebral vasodilatory effect of neuropeptide Y mediated by nitric oxide. Brain Res Bull 31: 443–448

    Article  CAS  PubMed  Google Scholar 

  19. You J, Zhang W, Jansen-Olesen I, Edvinsson L (1995) Relation between cyclic GMP generation and cerebrovascular reactivity; modulation by NPY and alpha-trinositol. Pharmacol Toxicol 77: 48–56

    CAS  PubMed  Google Scholar 

  20. Abounader R, Hamel E (1997) Associations between neuropeptide Y nerve terminals and intraparenchymal microvessels in rat and human cerebral cortex. J Comp Neurol 388: 444–453

    Article  CAS  PubMed  Google Scholar 

  21. Allen JM, Schon F, Todd N, Yeats JC, Crockard HA, Bloom SR (1984) Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasospasm. Lancet 2: 550–552

    CAS  PubMed  Google Scholar 

  22. Tuor U, Edvinsson L, McCulloch J (1985) Neuropeptide Y and cerebral blood flow. Lancet 1: 1271

    CAS  PubMed  Google Scholar 

  23. Suzuki Y, Shibuya M, Ikegaki I, Satoh S, Takayasu M, Asano T (1988) Effects of neuropeptide Y on canine cerebral circulation. Eur J Pharmacol 146: 271–277

    Article  CAS  PubMed  Google Scholar 

  24. Tuor U, Kelly PAT, Edvinsson L, McCulloch J (1990) Neuropeptide Y and the cerebral circulation. J Cereb Blood Flow Metab 10: 591–601

    CAS  PubMed  Google Scholar 

  25. Tuor U, Kelly PAT, Edvinsson L, Tatemoto K, McCulloch J (1985) Neuropeptide Y and the regulation of local cerebral blood flow: A quantitative autoradiographic study. J Cereb Blood Flow Metab 5: S513–S514

    Google Scholar 

  26. Goadsby PJ, Edvinsson L (1993) Examination of the involvement of neuropeptide Y (NPY) in cerebral autoregulation using the novel NPY antagonist PP56. Neuropeptides 24: 27–33

    Article  CAS  PubMed  Google Scholar 

  27. Vraamark T, Waldemar G, Edvinsson L, Paulson OB (1997) Differential effects of increasing doses of alpha-trinositol on cerebral autoregulation. Pharmacol Toxicol 80: 38–43

    CAS  PubMed  Google Scholar 

  28. Abel W, Han C, Noe BD, McDonald JK (1988) Neuropeptide Y: Vasoconstrictor effects and possible role in cerebral vasospasm after experimental subarachnoid hemorrhage. Brain Res 463: 250–258

    Article  CAS  PubMed  Google Scholar 

  29. Jackowski A, Crockard A, Burnstock G, Lincoln J (1989) Alterations in serotonin and neuropeptide content of cerebrovascular sympathetic nerves following experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab 9: 271–279

    CAS  PubMed  Google Scholar 

  30. Juul R, Edvinsson L, Fredriksen TA, Ekman R, Brubakl AO, Gisvold SE (1990) Changes in the levels of neuropeptide Y-LI in the external jugular vein in connection with vasoconstriction following subarachnoid haemorrhage in man; involvement of sympathetic neuropeptide Y in cerebral vasospasm. Acta Neurochir (Wien) 107: 75–81

    Article  CAS  Google Scholar 

  31. Suzuki Y, Sato S, Suzuki H, Namba J, Ohtake R, Hashigami Y, Suga S et al. (1989) Increased neuropeptide Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage. Stroke 20: 1680–1684

    CAS  PubMed  Google Scholar 

  32. Chen SH, Cheung RT (2002) Peripheral and central administration of neuropeptide Y in a rat middle cerebral artery occlusion stroke model reduces cerebral blood flow and increases infarct volume. Brain Res 15:927: 138–143

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Experimental Vascular Research, Department of Internal Medicine, Lund University Hospital, Lund, Sweden

    Lars Edvinsson

Authors
  1. Lars Edvinsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd., NW, Washington, DC, 20057, USA

    Zofia Zukowska

  2. Wyeth Research, Building A3153, 500 Arcola Rd, Collegeville, PA, 19426, USA

    Giora Z. Feuerstein

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Birkhäuser Verlag/Switzerland

About this chapter

Cite this chapter

Edvinsson, L. (2006). Neuropeptide Y and the cerebral circulation. In: Zukowska, Z., Feuerstein, G.Z. (eds) NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics. Experientia Supplementum, vol 95. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7417-9_7

Download citation

Publish with us

Policies and ethics

Search

Navigation