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NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function

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NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

Part of the book series: Experientia Supplementum ((EXS,volume 95))

Discussion and conclusion

There is not doubt today that NPY does play a role in regulating cytosolic and nuclear Ca2+ in heart cells including ventricular cardiomyocytes and EECs. The recent work in the literature including ours, agree that the major effect of NPY in both ventricular cardiomyocytes and EECs is mediated primarily by the activation of the Y1 and Y2 receptors. However, other NPY receptors may also contribute to the peptide’s effect on cardiomyocytes and EECs such as the Y5 receptors. The mechanisms by which these effects take place could be via indirect activation of the voltage dependent resting R-type Ca2+ channels. One important aspect that should be mentioned is that EECs could be an important source of NPY which may highly contribute to both circulating NPY as well as locally released NPY. Furthermore, the presence of different types of NPY receptors in the nuclear membranes may suggest that these receptors may also contribute to the modulation of nuclear function and more particularly to the regulation of nucleoplasmic Ca2+ metabolism which is known to modulate nuclear function and transport. It is very likely that overactivation of different NPY receptors in both cardiomyocytes and EECs and more particularly the Y1 and Y5 receptors could be implicated in hypertrophy and cardiac heart failure. We are quite sure that future work in the field of NPY and cardiac function will help us to better understand the implication of this peptide in cardiac physiopathology.

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Québec, J1H 5N4, Canada

    Danielle Jacques, Sawsan Sader, Claudine Perreault & Dima Abdel-Samad

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  1. Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd., NW, Washington, DC, 20057, USA

    Zofia Zukowska

  2. Wyeth Research, Building A3153, 500 Arcola Rd, Collegeville, PA, 19426, USA

    Giora Z. Feuerstein

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Jacques, D., Sader, S., Perreault, C., Abdel-Samad, D. (2006). NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function. In: Zukowska, Z., Feuerstein, G.Z. (eds) NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics. Experientia Supplementum, vol 95. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7417-9_5

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