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Post-Nobel science I

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Chapter 13

  • Cotton, R.G.H., Milstein. C. 1973. Fusion of two immunoglobulin-producing myeloma cells. Nature 244: 42.

    Article  PubMed  CAS  Google Scholar 

  • Grosschedl, R., Weaver, D., Baltimore, D., Costantini, F. 1984. Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38:647.

    Article  PubMed  CAS  Google Scholar 

  • Storb, U., O’Brien, R.L., McMullen, M.D., Gollahon, K.A., Brinster, R.L. 1984. High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes. Nature 310:238.

    Article  PubMed  CAS  Google Scholar 

  • Ochi, A., Hawley, R.G., Hawley, T., Shulman, M.J., Traunecker, A., Köhler, G., Hozumi, N. 1983. Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc. Nat. Acad. Sci. USA 80:6351.

    PubMed  CAS  Google Scholar 

  • Rusconi, S., Köhler, G. 1985. Transmission and expression of a specific pair of rearranged immunoglobulin mu and kappa genes in a transgenic mouse line. Nature 314:330.

    Article  PubMed  CAS  Google Scholar 

  • Leder. P. 1982. The genetics of antibody diversity. Sci. Am. 246:108.

    Article  Google Scholar 

  • Kindt, T. Capra, J.D. 1984. The antibody enigma. Plenum Press, New York, London

    Google Scholar 

  • Janeway, C.A. Jr., Travers, P., Walpot, M., Shlomchik, M.J. 2005. Immunobiology, the immune system in health and disease. 6th edition. GS Garland Science, New York, London.

    Google Scholar 

  • Kottmann, A.H., Brack, C., Eibel, H., Köhler, G. 1992. A survey of protein-DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ52 element. Eur. J. Immunol. 22:2113.

    PubMed  CAS  Google Scholar 

  • Kottmann, A, H., Zevnik, B., Welte, M., Nielsen, P.J., Köhler G. 1994. A second promoter and enhancer element within the immunoglobulin heavy chain locus. Eur. J. Immunol. 24:817.

    PubMed  CAS  Google Scholar 

  • Iglesias, A., Lamers, M., Köhler, G. 1987. Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice. Nature 330:482.

    Article  PubMed  CAS  Google Scholar 

  • Köhler, G. 1989. Allelic exclusion-one facet of B-cell development. Immunol. Today 10:11.

    Google Scholar 

  • Melchers, F., ten Boekel, E., Yamagami, T., Andersson, J., Rolink, A. 1999. The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci. Semin. Immunol. 11:307

    Article  PubMed  CAS  Google Scholar 

  • Loffert, D., Schaal, S., Ehlich, A., Hardy, R.R., Zou, Y.R., Muller, W., Rajewsky, K. 1994. Early B-cell development in the mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137:135.

    PubMed  CAS  Google Scholar 

  • Nitschke, L., Kosco, M.H., Köhler, G., Lamers, M.C. 1993. Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and-dependent antigens. Proc. Nat. Acad. Sci. USA 90:1887.

    PubMed  CAS  Google Scholar 

  • Rammensee, H.G., Julius, M.H., Nemazee, D., Langhorne, J., Lamers, R., Köhler, G. 1987. Targeting cytotoxic T cells to antigen-specific B lymphocytes. Eur. J. Immunol. 17:433.

    PubMed  CAS  Google Scholar 

  • Julius, M.H., Rammensee, H.G., Ratcliffe, M.J., Lamers, M.C., Langhorne, J., Köhler, G. 1988. The molecular interactions with helper T cells which limit antigen-specific B cell differentiation. Eur. J. Immunol. 18:381.

    PubMed  CAS  Google Scholar 

  • Brombacher, F., Lamers, M.C., Köhler, G., Eibel, H. 1989. Elimination of CD8+ thymocytes in transgenic mice expressing an anti-Lyt2.2 immunoglobulin heavy chain gene. EMBO J. 8:3719.

    PubMed  CAS  Google Scholar 

  • Brombacher, F., Köhler, G., Eibel, H. 1991. B cell tolerance in mice transgenic for anti-CD8 immunoglobulin mu chain. J. Exp. Med. 174:1335.

    Article  PubMed  CAS  Google Scholar 

  • Theopold, U., Köhler, G. 1990. Partial tolerance in beta-galactosidase-transgenic mice. Eur. J. Immunol. 20:1311.

    PubMed  CAS  Google Scholar 

  • Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, T.B., Smith-Gill, S.J., Brink, R.A., Pritchard-Briscoe, H., Wotherspoon, J.S., Loblay, R.H., Raphael, K, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.

    Article  PubMed  CAS  Google Scholar 

  • Nemazee, D.A., Burki, K. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.

    Article  PubMed  CAS  Google Scholar 

  • Götz, J., Eibel, H., Köhler, G. 1990. Non-tolerance and differential susceptibility to diabetes in transgenic mice expressing major histocompatibility class II genes on pancreatic beta cells. Eur. J. Immunol. 20:1677.

    PubMed  Google Scholar 

  • Allison, J., Campbell, I.L., Morahan, G., Mandel, T.E., Harrison, L.C., Miller, J.F. 1988. Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 333:529.

    Article  PubMed  CAS  Google Scholar 

  • Lo, D., Burkly, L.C., Widera, G., Cowing, C., Flavell, R.A., Palmiter, R.D., Brinster, R.L. 1988. Diabetes and tolerance in transgenic mice expressing class II MHC moleculein pancreatic beta cells. Cell 53:159.

    Article  PubMed  CAS  Google Scholar 

  • Sarvetnick, N., Liggitt, D., Pitts, S.L., Hansen, S.E., Stewart, T.A. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52:773.

    Article  PubMed  CAS  Google Scholar 

  • Bohme, J., Haskins, K., Stecha, P., van Ewijk, W., LeMeur M., Gerlinger, P., Benoist, C., Mathis, D. 1989. Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. Science 244:1179.

    PubMed  CAS  Google Scholar 

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(2005). Post-Nobel science I. In: Köhler’s Invention. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7413-6_13

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