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Role of voltage-gated sodium channels in oral and craniofacial pain

  • Chapter
Sodium Channels, Pain, and Analgesia

Part of the book series: Progress in Inflammation Research ((PIR))

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Summary and conclusions

Because of their fundamental role in action potential generation, VGSCs are critical for neuronal excitability. Evidence collected over the last 10 years indicates that the biophysical properties, expression pattern and/or distribution of VGSCs are subject to change and that such changes underlie pain associated with injury. The majority of this evidence has come from study of spinal afferents where specific patterns of changes in VGSCs have been well characterized. Even though there is compelling evidence to suggest that there may be differences between oral or craniofacial structures, and somatic and visceral structures with respect to the response to injury, studies of trigeminal nerves have revealed a number of important similarities between the two, including the VGSCs expressed, and their biophysical properties, distribution and functional role in sensory afferents. There are also similarities between spinal and trigeminal nerves with respect to the response to injury. However, there are also important differences, several of which may impact therapeutic interventions employed for the treatment of specific pain syndromes.

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Authors and Affiliations

  1. Department of Biomedical Sciences Dental School, Program in Neuroscience, USA

    Michael S. Gold

  2. Department of Anatomy and Neurobiology, Medical School, University of Maryland, Baltimore, MD, 21201, USA

    Michael S. Gold

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  1. Michael S. Gold
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  1. PLIVA Research Institute Ltd., Prilaz baruna Filipovića 29, HR-10000, Zagreb, Croatia

    Michael J. Parnham PhD (Senior Scientific Advisor) (Senior Scientific Advisor)

  2. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK

    Kevin Coward

  3. Molecular Nociception Group Department of Biology Medawar Building, University College London, Gower Street, London, WC1E 6BT, UK

    Mark D. Baker

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© 2005 Birkhäuser Verlag Basel/Switzerland

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Gold, M.S. (2005). Role of voltage-gated sodium channels in oral and craniofacial pain. In: Parnham, M.J., Coward, K., Baker, M.D. (eds) Sodium Channels, Pain, and Analgesia. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7411-X_8

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  • DOI: https://doi.org/10.1007/3-7643-7411-X_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-7062-6

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