Skip to main content
SpringerLink
Log in

TRPV1 distribution and regulation

  • Chapter
Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

  • 861 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Buck SH, Burks TF (1986) The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev 38: 179–226

    PubMed  CAS  Google Scholar 

  2. Theriault E, Otsuka M, Jessell T (1979) Capsaicin-evoked release of substance P from primary sensory neurons. Brain Res 170: 209–213

    Article  PubMed  CAS  Google Scholar 

  3. Ritter S, Dinh TT (1988) Capsaicin-induced neuronal degeneration: silver impregnation of cell bodies, axons, and terminals in the central nervous system of the adult rat. J Comp Neurol 271: 79–90

    Article  PubMed  CAS  Google Scholar 

  4. Winter J (1987) Characterization of capsaicin-sensitive neurones in adult rat dorsal root ganglion cultures. Neurosci Lett 80: 134–140

    Article  PubMed  CAS  Google Scholar 

  5. Winter J, Walpole CS, Bevan S, James IF (1993) Characterization of resiniferatoxin binding sites on sensory neurons: co-regulation of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia. Neuroscience 57: 747–757

    Article  PubMed  CAS  Google Scholar 

  6. Meyers JR, MacDonald RB, Duggan A, Lenzi D, Standaert DG, Corwin JT, Corey DP (2003) Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels. J Neurosci 23: 4054–4065

    PubMed  CAS  Google Scholar 

  7. Caterina MJ (2003) Vanilloid receptors take a TRP beyond the sensory afferent. Pain 105: 5–9

    Article  PubMed  CAS  Google Scholar 

  8. Szallasi A (2002) Vanilloid (capsaicin) receptors in health and disease. Am J Clin Pathol 118: 110–121

    PubMed  CAS  Google Scholar 

  9. Lawson SN (1987) The morphological consequences of neonatal treatment with capsaicin on primary afferent neurones in adult rats. Acta Physiol Hung 69: 315–321

    PubMed  CAS  Google Scholar 

  10. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816–824

    PubMed  CAS  Google Scholar 

  11. Ma QP (2001) Vanilloid receptor homologue, VRL1, is expressed by both A-and C-fiber sensory neurons. Neuroreport 12: 3693–3695

    PubMed  CAS  Google Scholar 

  12. Ichikawa H, Sugimoto T (2001) VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion. Brain Res 890: 184–188

    Article  PubMed  CAS  Google Scholar 

  13. Dinh QT, Groneberg DA, Mingomataj E, Peiser C, Heppt W, Dinh S, Arck PC, Klapp BF, Fischer A (2003) Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa. Neuropeptides 37: 245–250

    Article  PubMed  CAS  Google Scholar 

  14. Hou M, Uddman R, Tajti J, Kanje M, Edvinsson L (2002) Capsaicin receptor immunoreactivity in the human trigeminal ganglion. Neurosci Lett 330: 223–226

    Article  PubMed  CAS  Google Scholar 

  15. Matsumoto I, Emori Y, Ninomiya Y, Abe K (2001) A comparative study of three cranial sensory ganglia projecting into the oral cavity: in situ hybridization analyses of neurotrophin receptors and thermosensitive cation channels. Brain Res Mol Brain Res 93: 105–112

    PubMed  CAS  Google Scholar 

  16. Ichikawa H, Sugimoto T (2003) The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia. Brain Res 980: 293–296

    PubMed  CAS  Google Scholar 

  17. Helliwell RJ, McLatchie LM, Clarke M, Winter J, Bevan S, McIntyre P (1998) Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia. Neurosci Lett 250: 177–180

    Article  PubMed  CAS  Google Scholar 

  18. Zhang L, Jones S, Brody K, Costa M, Brookes SJ (2004) Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. Am J Physiol Gastrointest Liver Physiol 286: G983–G991

    PubMed  CAS  Google Scholar 

  19. Wood JN, Winter J, James IF, Rang HP, Yeats J, Bevan S (1988) Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Neurosci 8: 3208–3220

    PubMed  CAS  Google Scholar 

  20. Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36: 57–68

    Article  PubMed  CAS  Google Scholar 

  21. Pare M, Elde R, Mazurkiewicz JE, Smith AM, Rice FL (2001) The Meissner corpuscle revised: a multiafferented mechanoreceptor with nociceptor immunochemical properties. J Neurosci 21: 7236–7246

    PubMed  CAS  Google Scholar 

  22. Ishida Y, Ugawa S, Ueda T, Murakami S, Shimada S (2002) Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae. Brain Res Mol Brain Res 107: 17–22

    PubMed  CAS  Google Scholar 

  23. Vass Z, Dai CF, Steyger PS, Jancso G, Trune DR, Nuttall AL (2004) Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries. Neuroscience 124: 919–927

    Article  PubMed  CAS  Google Scholar 

  24. Guo A, Vulchanova L, Wang J, Li X, Elde R (1999) Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11: 946–958

    Article  PubMed  CAS  Google Scholar 

  25. Guo A, Simone DA, Stone LS, Fairbanks CA, Wang J, Elde R (2001) Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons. Eur J Neurosci 14: 293–304

    Article  PubMed  CAS  Google Scholar 

  26. Doly S, Fischer J, Salio C, Conrath M (2004) The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes. Neurosci Lett 357: 123–126

    Article  PubMed  CAS  Google Scholar 

  27. Doly S, Fischer J, Conrath M (2004) The vanilloid receptor-1 (TRPV1) is expressed in some rat dorsal horn NK1 cells. Brain Res 1004: 203–207

    Article  PubMed  CAS  Google Scholar 

  28. Dux M, Santha P, Jancso G (2003) Capsaicin-sensitive neurogenic sensory vasodilatation in the dura mater of the rat. J Physiol 552: 859–867

    Article  PubMed  CAS  Google Scholar 

  29. Trevisani M, Smart D, Gunthorpe MJ, Tognetto M, Barbieri M, Campi B, Amadesi S, Gray J, Jerman JC, Brough SJ et al (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 5: 546–551

    Article  PubMed  CAS  Google Scholar 

  30. Renton T, Yiangou Y, Baecker PA, Ford AP, Anand P (2003) Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. J Orofac Pain 17: 245–250

    PubMed  Google Scholar 

  31. Stenholm E, Bongenhielm U, Ahlquist M, Fried K (2002) VRl-and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat. Acta Odontol Scand 60: 72–79

    Article  PubMed  Google Scholar 

  32. Hu-Tsai M, Winter J, Woolf CJ (1992) Regional differences in the distribution of capsaicin-sensitive target-identified adult rat dorsal root ganglion neurons. Neurosci Lett 143: 251–254

    Article  PubMed  CAS  Google Scholar 

  33. Yiangou Y, Facer P, Dyer NH, Chan CL, Knowles C, Williams NS, Anand P (2001) Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet 357: 1338–1339

    Article  PubMed  CAS  Google Scholar 

  34. Tympanidis P, Casula MA, Yiangou Y, Terenghi G, Dowd P, Anand P (2004) Increased vanilloid receptor VR1 innervation in vulvodynia. Eur J Pain 8: 129–133

    Article  PubMed  CAS  Google Scholar 

  35. Chan CL, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P (2003) Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet 361: 385–391

    PubMed  CAS  Google Scholar 

  36. Geppetti P, Trevisani M (2004) Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol 141: 1313–1320

    Article  PubMed  CAS  Google Scholar 

  37. Kato S, Aihara E, Nakamura A, Xin H, Matsui H, Kohama K, Takeuchi K (2003) Expression of vanilloid receptors in rat gastric epithelial cells: role in cellular protection. Biochem Pharmacol 66: 1115–1121

    Article  PubMed  CAS  Google Scholar 

  38. Horie S, Yamamoto H, Michael GJ, Uchida M, Belai A, Watanabe K, Priestley JV, Murayama T (2004) Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats. Scand J Gastroenterol 39: 303–312

    Article  PubMed  CAS  Google Scholar 

  39. Avelino A, Cruz C, Nagy I, Cruz F (2002) Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 109: 787–798

    Article  PubMed  CAS  Google Scholar 

  40. Zahner MR, Li DP, Chen SR, Pan HL (2003) Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol 551: 515–523

    Article  PubMed  CAS  Google Scholar 

  41. Morice AH, Geppetti P (2004) Cough. 5: The type 1 vanilloid receptor: a sensory receptor for cough. Thorax 59: 257–258

    Article  PubMed  CAS  Google Scholar 

  42. Roberts JC, Davis JB, Benham CD (2004) [3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution. Brain Res 995: 176–183

    Article  PubMed  CAS  Google Scholar 

  43. Mezey E, Toth ZE, Cortright DN, Arzubi MK, Krause JE, Elde R, Guo A, Blumberg PM, Szallasi A (2000) Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc Natl Acad Sci USA 97: 3655–3660

    Article  PubMed  CAS  Google Scholar 

  44. Jancso-Gabor A, Szolcsanyi J, Jancso N (1970) Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J Physiol 206: 495–507

    PubMed  CAS  Google Scholar 

  45. Veldhuis WB, van der Stelt SM, Wadman MW, van Zadelhoff G, Maccarrone M, Fezza F, Veldink GA, Vliegenthart JF, Bar PR, Nicolay K et al (2003) Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases. J Neurosci 23: 4127–4133

    PubMed  CAS  Google Scholar 

  46. Lastres-Becker I, de Miguel R, De Petrocellis L, Makriyannis A, Di Marzo V, Fernandez-Ruiz J (2003) Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington’s disease. J Neurochem 84: 1097–1109

    Article  PubMed  CAS  Google Scholar 

  47. Agopyan N, Head J, Yu S, Simon SA (2004) TRPV1 receptors mediate particulate matter-induced apoptosis. Am J Physiol Lung Cell Mol Physiol 286: L563–L572

    Article  PubMed  CAS  Google Scholar 

  48. Burbach GJ, Kim KH, Zivony AS, Kim A, Aranda J, Wright S, Naik SM, Caughman SW, Ansel JC, Armstrong CA (2001) The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor. J Invest Dermatol 117: 1075–1082

    Article  PubMed  CAS  Google Scholar 

  49. Southall MD, Li T, Gharibova LS, Pei Y, Nicol GD, Travers JB (2003) Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes. J Pharmacol Exp Ther 304: 217–222

    Article  PubMed  CAS  Google Scholar 

  50. Inoue K, Koizumi S, Fuziwara S, Denda S, Inoue K, Denda M (2002) Functional vanilloid receptors in cultured normal human epidermal keratinocytes. Biochem Biophys Res Commun 291: 124–129

    Article  PubMed  CAS  Google Scholar 

  51. Denda M, Fuziwara S, Inoue K, Denda S, Akamatsu H, Tomitaka A, Matsunaga K (2001) Immunoreactivity of VR1 on epidermal keratinocyte of human skin. Biochem Biophys Res Commun 285: 1250–1252

    Article  PubMed  CAS  Google Scholar 

  52. Stander S, Moormann C, Schumacher M, Buddenkotte J, Artuc M, Shpacovitch V, Brzoska T, Lippert U, Henz BM, Luger TA et al (2004) Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol 13: 129–139

    Article  PubMed  Google Scholar 

  53. Patel PS, Yang S, Li A, Varney ML, Singh RK (2002) Capsaicin regulates vascular endothelial cell growth factor expression by modulation of hypoxia inducing factor-1alpha in human malignant melanoma cells. J Cancer Res Clin Oncol 128: 461–468

    Article  PubMed  CAS  Google Scholar 

  54. Cruz F (2004) Mechanisms involved in new therapies for overactive bladder. Urology 63: 65–73

    Article  PubMed  Google Scholar 

  55. Akiba Y, Kato S, Katsube K, Nakamura M, Takeuchi K, Ishii H, Hibi T (2004) Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 321: 219–225

    Article  PubMed  CAS  Google Scholar 

  56. Hudson LJ, Bevan S, Wotherspoon G, Gentry C, Fox A, Winter J (2001) VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur J Neurosci 13: 2105–2114

    Article  PubMed  CAS  Google Scholar 

  57. Michael GJ, Priestley JV (1999) Differential expression of the mRNA for the vanilloid receptor subtype I in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. J Neurosci 19: 1844–1854

    PubMed  CAS  Google Scholar 

  58. Fukuoka T, Tokunaga A, Tachibana T, Dai Y, Yamanaka H, Noguchi K (2002) VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation. Pain 99: 111–120

    Article  PubMed  CAS  Google Scholar 

  59. Ritter AM, Mendell LM (1992) Somal membrane properties of physiologically identified sensory neurons in the rat: effects of nerve growth factor. J Neurophysiol 68: 2033–2041

    PubMed  CAS  Google Scholar 

  60. Rashid MH, Inoue M, Kondo S, Kawashima T, Bakoshi S, Ueda H (2003) Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain. J Pharmacol Exp Ther 304: 940–948

    PubMed  CAS  Google Scholar 

  61. Rashid MH, Inoue M, Bakoshi S, Ueda H (2003) Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice. J Pharmacol Exp Ther 306: 709–717

    Article  PubMed  CAS  Google Scholar 

  62. Nicholas RS, Winter J, Wren P, Bergmann R, Woolf CJ (1999) Peripheral inflammation increases the capsaicin sensitivity of dorsal root ganglion neurons in a nerve growth factor-dependent manner. Neuroscience 91: 1425–1433

    Article  PubMed  CAS  Google Scholar 

  63. Amaya F, Oh-hashi K, Naruse Y, Iijima N, Ueda M, Shimosato G, Tominaga M, Tanaka Y, Tanaka M (2003) Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons. Brain Res 963: 190–196

    Article  PubMed  CAS  Google Scholar 

  64. Tohda C, Sasaki M, Konemura T, Sasamura T, Itoh M, Kuraishi Y (2001) Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity. J Neurochem 76: 1628–1635

    Article  PubMed  CAS  Google Scholar 

  65. Bevan S, Winter J (1995) Nerve growth factor (NGF) differentially regulates the chemosensitivity of adult rat cultured sensory neurons. J Neurosci 15: 4918–4926

    PubMed  CAS  Google Scholar 

  66. Ogun-Muyiwa P, Helliwell R, McIntyre P, Winter J (1999) Glial cell line derived neurotrophic factor (GDNF) regulates VR1 and substance P in cultured sensory neurons. Neuroreport 10: 2107–2111

    PubMed  CAS  Google Scholar 

  67. Bron R, Klesse LJ, Shah K, Parada LF, Winter J (2003) Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci 22: 118–132

    Article  PubMed  CAS  Google Scholar 

  68. Winter J (1998) Brain derived neurotrophic factor, but not nerve growth factor, regulates capsaicin sensitivity of rat vagal ganglion neurones. Neurosci Lett 241: 21–24

    Article  PubMed  CAS  Google Scholar 

  69. Winston J, Toma H, Shenoy M, Pasricha PJ (2001) Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 89: 181–186

    Article  PubMed  CAS  Google Scholar 

  70. Huang EJ, Reichardt LF (2003) Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72: 609–642

    Article  PubMed  CAS  Google Scholar 

  71. Ganju P, O’Bryan JP, Der C, Winter J, James IF (1998) Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells. Eur J Neurosci 10: 1995–2008

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Novartis Institute for Medical Sciences, 5 Gower Place, London, WC1E 6BN, UK

    Janet Winter

Authors
  1. Janet Winter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, CA, 94080, USA

    Annika B. Malmberg

  2. NeurogesX, Inc., 981F Industrial Road, San Carlos, CA, 94070, USA

    Keith R. Bley

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Winter, J. (2005). TRPV1 distribution and regulation. In: Malmberg, A.B., Bley, K.R. (eds) Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7379-2_3

Download citation

  • DOI: https://doi.org/10.1007/3-7643-7379-2_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-7080-0

  • Online ISBN: 978-3-7643-7379-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation