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Modulation of neurotransmitter release and metabolism

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Book cover St. John’s Wort and its Active Principles in Depression and Anxiety

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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References

  1. Lecrubier Y, Clerc G, Didi R, Kieser M (2002) Efficacy of St. John’s Wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial. Am J Psychiatry 159: 1361–1366

    Article  PubMed  Google Scholar 

  2. Barnes J, Anderson LA, Phillipson JD (2001) St John’s Wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol 53: 583–600

    Google Scholar 

  3. Müller WE (2003) Current St John’s Wort research from mode of action to clinical efficacy. Pharmacol Res 47: 101–109

    Article  PubMed  Google Scholar 

  4. Butterweck V (2003) Mechanism of action of St John’s Wort in depression: what is known? CNS Drugs 17: 539–562

    PubMed  Google Scholar 

  5. Coppen A (1967) The biochemistry of affective disorders. Br J Psychiatry 113: 1237–1264

    PubMed  Google Scholar 

  6. Kehr J, Fuxe K, Ungerstedt U, Svensson TH (eds): (2003) Monitoring Molecules in Neuroscience. Karolinska University, Stockholm

    Google Scholar 

  7. Dawson LA, Nguyen HQ, Geiger A (1999) Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism. Neuropharmacology 38: 1153–1163

    Article  PubMed  Google Scholar 

  8. Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong DT (2001) Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 25: 871–880

    Article  PubMed  Google Scholar 

  9. Müller WE, Singer A, Wonnemann M, Hafner U, Rolli M, Schafer C (1998) Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiatry 31(Suppl 1): 16–21

    PubMed  Google Scholar 

  10. Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998) Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci 63: 499–510

    Google Scholar 

  11. Kientsch U, Burgi S, Ruedeberg C, Probst S, Honegger UE (2001) St. John’s Wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells. Pharmacopsychiatry 34(Suppl 1): S56–60

    Article  PubMed  Google Scholar 

  12. Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J, Popadak B, Ernsberger P, Roth BL (2002) In vitro receptor screening of pure constituents of St. John’s Wort reveals novel interactions with a number of GPCRs. Psychopharmacology 162: 193–202

    Article  PubMed  Google Scholar 

  13. Calapai G, Crupi A, Firenzuoli F, Costantino G, Inferrera G, Campo GM, Caputi AP (1999) Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat. J Pharm Pharmacol 51: 723–728

    Article  PubMed  Google Scholar 

  14. Calapai G, Crupi A, Firenzuoli F, Inferrera G, Squadrito F, Parisi A, De Sarro G, Caputi A (2001) Serotonin, norepinephrine and dopamine involvement in the antidepressant action of Hypericum perforatum. Pharmacopsychiatry 34: 45–49

    Article  PubMed  Google Scholar 

  15. Yu PH (2000) Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain. Pharmacopsychiatry 33: 60–65

    Article  PubMed  Google Scholar 

  16. Butterweck V, Bockers T, Korte B, Wittkowski W, Winterhoff H (2002) Long-term effects of St. John’s Wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. Brain Res 930: 21–29

    Article  PubMed  Google Scholar 

  17. Kaehler ST, Sinner C, Chatterjee SS, Philippu A (1999) Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus. Neurosci Lett 262: 199–202

    Article  PubMed  Google Scholar 

  18. Franklin M, Cowen PJ (2001) Researching the antidepressant actions of Hypericum perforatum (St. John’s Wort) in animals and man. Pharmacopsychiatry 34(Suppl 1): S29–37

    Article  PubMed  Google Scholar 

  19. Perovic S, Müller WE (1995) Pharmacological profile of Hypericum extract. Effect on serotonin uptake by postsynaptic receptors. Arzneimittelforschung 45: 1145–1148

    PubMed  Google Scholar 

  20. Singer A, Wonnemann M, Müller WE (1999) Hyperforin, a major antidepressant constituent of St. John’s Wort, inhibits serotonin uptake by elevating free intracellular Na+1. J Pharmacol Exp Ther 290: 1363–1368

    PubMed  Google Scholar 

  21. Wonnemann M, Singer A, Siebert B, Müller WE (2001) Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John’s Wort. Pharmacopsychiatry 34(Suppl 1): S148–151

    PubMed  Google Scholar 

  22. Gobbi M, Valle FD, Ciapparelli C, Diomede L, Morazzoni P, Verotta L, Caccia S, Cervo L, Mennini T (1999) Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol 360: 262–269

    Article  PubMed  Google Scholar 

  23. Roz N, Mazur Y, Hirshfeld A, Rehavi M (2002) Inhibition of vesicular uptake of monoamines by hyperforin. Life Sci 71: 2227–2237

    PubMed  Google Scholar 

  24. Roz N, Rehavi M (2003) Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane. Life Sci 73: 461–470

    PubMed  Google Scholar 

  25. Bhattacharya SK, Chakrabarti A, Chatterjee SS (1998) Activity profiles of two hyperforin containing Hypericum extracts in behavioral models. Pharmacopsychiatry 31(Suppl 1): 22–29

    PubMed  Google Scholar 

  26. Cervo L, Rozio M, Ekalle-Soppo CB, Guiso G, Morazzoni P, Caccia S (2002) Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts. Psychopharmacology 164: 423–428

    Article  PubMed  Google Scholar 

  27. Misane I, Ogren SO (2001) Effects of Hypericum perforatum (St. John’s Wort) on passive avoidance in the rat: evaluation of potential neurochemical mechanisms underlying its antidepressant activity. Pharmacopsychiatry 34(Suppl 1): S89–97

    PubMed  Google Scholar 

  28. Butterweck V, Christoffel V, Nahrstedt A, Petereit F, Spengler B, Winterhoff H (2003) Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models. Life Sci 73: 627–639

    PubMed  Google Scholar 

  29. Yoshitake T, Iizuka R, Yoshitake S, Weikop P, Müller WE, Ogren SO, Kehr J (2004) Hypericum perforatum L (St. John’s Wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol 142: 414–418

    PubMed  Google Scholar 

  30. Yoshitake T, Kehr J, Yoshitake S, Fujino K, Nohta H, Yamaguchi M (2004) Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine. J Chromatogr B Analyt Technol Biomed Life Sci 807: 177–183

    PubMed  Google Scholar 

  31. Kehr J (1999) Monitoring chemistry of brain microenvironment: biosensors, microdialysis and related techniques. In: U Windhorst, H Johansson (eds): Modern techniques in neuroscience research. Springer-Verlag GmbH, Heidelberg. Chapter 41: 1149–1198

    Google Scholar 

  32. Rommelspacher H, Siemanowitz B, Mannel M (2001) Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens. Pharmacopsychiatry 34(Suppl 1): S119–126

    PubMed  Google Scholar 

  33. Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (2000) Effect of acute administration of Hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system. Pharmacopsychiatry 33: 14–18

    Google Scholar 

  34. Fornal CA, Metzler CW, Mirescu C, Stein SK, Jacobs BL (2001) Effects of standardized extracts of St. John’s Wort on the single-unit activity of serotonergic dorsal Raphe neurons in awake cats: comparisons with fluoxetine and sertraline. Neuropsychopharmacology 25: 858–870

    PubMed  Google Scholar 

  35. D’Aquila PS, Collu M, Gessa GL, Serra G (2000) The role of dopamine in the mechanism of action of antidepressant drugs. Eur J Pharmacol 405: 365–373

    PubMed  Google Scholar 

  36. Willner P (1997) The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol 12(Suppl 3): S7–14

    Google Scholar 

  37. Gambarana C, Tolu PL, Masi F, Rinaldi M, Giachetti D, Morazzoni P, De Montis MG (2001) A study of the antidepressant activity of Hypericum perforatum on animal models. Pharmacopsychiatry 34(Suppl 1): S42–44

    PubMed  Google Scholar 

  38. Franklin M, Chi J, McGavin C, Hockney R, Reed A, Campling G, Whale RW, Cowen PJ (1999) Neuroendocrine evidence for dopaminergic actions of Hypericum extract (LI 160) in healthy volunteers. Biol Psychiatry 46: 581–584

    Article  PubMed  Google Scholar 

  39. Franklin M, Chi JD, Mannel M, Cowen PJ (2000) Acute effects of LI 160 (extract of Hypericum perforatum, St John’s Wort) and two of its constituents on neuroendocrine responses in the rat. J Psychopharmacol 14: 360–363

    PubMed  Google Scholar 

  40. Widy-Tyszkiewicz E, Piechal A, Joniec I, Blecharz-Klin K (2002) Long term administration of Hypericum perforatum improves spatial learning and memory in the water maze. Biol Pharm Bull 10: 1289–1294

    Google Scholar 

  41. Buchholzer ML, Dvorak C, Chatterjee SS, Klein J (2002) Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John’s Wort. J Pharmacol Exp Ther 301: 714–719

    PubMed  Google Scholar 

  42. Re L, Corneli C, Sturani E, Paolucci G, Rossini F, Leon OS, Martinez G, Bordicchia M, Tomassetti Q (2003) Effects of Hypericum extract on the acetylcholine release: a loose patch clamp approach. Pharmacol Res 48: 55–60

    PubMed  Google Scholar 

  43. Wonnemann M, Singer A, Müller WE (2000) Inhibition of synaptosomal uptake of 3H-Lglutamate and 3H-GABA by hyperforin, a major constituent of St. John’s Wort: the role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology 23: 188–197

    Article  PubMed  Google Scholar 

  44. Marsh WL, Davies JA (2002) The involvement of sodium and calcium ions in the release of amino acid neurotransmitters from mouse cortical slices elicited by hyperforin. Life Sci 71: 2645–2655

    PubMed  Google Scholar 

  45. Clapp-Lilly KL, Roberts RC, Duffy LK, Irons KP, Hu Y, Drew KL (1999) An ultrastructural analysis of tissue surrounding a microdialysis probe. J Neurosci Methods 90: 129–142

    PubMed  Google Scholar 

  46. Langosch JM, Zhou XY, Heinen M, Kupferschmid S, Chatterjee SS, Noldner M, Walden J (2002) St John’s Wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors. Eur Neuropsychopharmacol 12: 209–216

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 171 77, Stockholm, Sweden

    Takashi Yoshitake

Authors
  1. Jan Kehr
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  2. Sven Ove Ögren
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  3. Takashi Yoshitake
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Editor information

Editors and Affiliations

  1. Pharmakologisches Institut für Naturwissenschaftler, Biozentrum Universität Frankfurt, Marie-Curie-Str.9, 60439, Frankfurt, Germany

    Walter E. Müller

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© 2005 Birkhäuser Verlag/Switzerland

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Kehr, J., Ögren, S.O., Yoshitake, T. (2005). Modulation of neurotransmitter release and metabolism. In: Müller, W.E. (eds) St. John’s Wort and its Active Principles in Depression and Anxiety. Milestones in Drug Therapy MDT. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7338-5_5

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