Skip to main content

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tuomisto J, Mannisto P (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 37: 249–332

    PubMed  Google Scholar 

  2. Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10: 35–53

    PubMed  Google Scholar 

  3. Yatham LN, Steiner M (1993) Neuroendocrine probes of serotonergic function: a critical review. Life Sci 53: 447–463

    Article  PubMed  Google Scholar 

  4. Vorbach EU, Arnoldt KH, Hubner WD (1997) Efficacy and tolerability of St John’s Wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry 30(Suppl 2): 81–85

    PubMed  Google Scholar 

  5. Müller WE, Rolli M, Schafer C, Hafner U (1997) Effects of Hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 30(Suppl 2): 102–107

    PubMed  Google Scholar 

  6. Franklin M, McGavin C, Reed A, Cowen PJ (1998) Effect of Hypericum perforatum on salivary cortisol in healthy male volunteers. J Psychopharmacol 30(Suppl): A16

    Google Scholar 

  7. Schule C, Baghai T, Ferrera A, Laakmann G (2001) Neuroendocrine effects of Hypericum extract WS 5570 in 12 healthy volunteers. Pharmacopsychiatry 34(Suppl): 127–133

    Article  Google Scholar 

  8. Laakmann G (1987) Psychopharmacoendocrinology and Depression Research. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  9. Schule C, Baghai T, Sauer N, Laakmann G (2004) Endocrinological effects of high-dose Hypericum perforatum extract WS5570 in healthy subjects. Neuropsychobiology 49: 58–63

    Article  PubMed  Google Scholar 

  10. Franklin M, Chi J, McGavin C, Hockney R, Reed A, Campling G, Whale RWR, Cowen PJ (1999) Neuroendocrine evidence for dopaminergic actions of Hypericum extract (LI 160) in healthy volunteers. Biol Psychiatry 46: 581–584

    Article  PubMed  Google Scholar 

  11. Müller WE, Singer A, Wonnermann M, Hafner U, Rolli M, Schafer C (1998) Hyperforin represents the neurotransmitter re-uptake inhibiting constituent of Hypericum extract. Pharmacopsychiatry 31(Suppl 1): 16–21

    PubMed  Google Scholar 

  12. Franklin M, Chi J, Mannel M, Cowen PJ (2000) Acute effects of LI 160 (extract of Hypericum perforatum, St John’s Wort) and two of its constituents on neuroendocrine responses in the rat. J Psychopharmacol 14: 360–363

    PubMed  Google Scholar 

  13. Calapai G, Crupi A, Firenzuoli F, Costantino G, Inferrera G, Campo GM, Caputi AP (1999) Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline, dopamine in the cortex, diencephalons and brain stem of rats. J Pharm Pharmacol 51: 723–728

    Article  PubMed  Google Scholar 

  14. Kaehler ST, Sinner C, Chattergee SS, Philippu A (1999) Hyperforin enhances serotonin and glutamate in the rat locus ceoruleus. Neurosci Lett 262: 199–202

    Article  PubMed  Google Scholar 

  15. Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (2000) Effect of acute administration of hypericum-CO2 extract on dopamine and serotonin release in the rat central nervous system. Pharmacopsychiatry 33: 14–18

    Google Scholar 

  16. Kehr J, Yoshitake T, Yoshitake S, Ogren SO (2003) Differential effects of acute and repeated administration of Hypericum perforatum (St John’s Wort) on extracellular levels of serotonin, noradrenaline and dopamine in pre-frontal cortex, striatum and hippocampus in the rat. Eur Neuropsychopharmacol 12: S203

    Google Scholar 

  17. Franklin M (2003) Sub-chronic treatment effects of an extract of Hypericum perforatum (St John’s Wort, LI 160) on neuroendocrine responses to the 5-HT2A agonist, DOI in the rat. Pharmacopsychiatry 36: 161–164

    PubMed  Google Scholar 

  18. Bagdy G, Macara GB (1994) Hypothalamic paraventricular nucleus lesions differentially effect 5-HT1A and 5-HT2 receptor agonist-induced oxytocin, prolactin and corticosterone responses. Endocrinology 134: 1127–1131

    PubMed  Google Scholar 

  19. Butterweck V, Winterhoff H, Herkanham M (2001) St John’s Wort, hypericin and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Mol Psychiatry 6: 547–564

    Article  PubMed  Google Scholar 

  20. Hennessy M, Kellerher D. Spiers JP, Kavanagh P, Back D, Mulcahy F, Feely J (2002) St Johns Wort increases expression of P-glycoprotein: implications for drug interactions. Br J Clin Pharmacol 53: 75–82

    PubMed  Google Scholar 

  21. Perloff MD, von Moltke LL, Stormer E, Shader RI, Greenblatt DJ (2001) Saint John’s Wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. Br J Pharmacol 134: 1601–1608

    PubMed  Google Scholar 

  22. Butterweck V, Korte B, Winterhoff H (2001) Pharmacological and endocrine effect of Hypericum perforatum and hypericin after repeated treatment. Pharmacopsychiatry 34(Suppl 1): 52–57

    Google Scholar 

  23. Franklin M, Cowen PJ (2001) Researching the antidepressant actions of Hypericum perforatum (St John’s Wort) in animals and man. Pharmacopsychiatry 34(Suppl 1): S29–S37

    Article  PubMed  Google Scholar 

  24. Makina DM, Taranukhin AG, Chernigovskaya EV, Kuzik VV (2001) Effect of Hypericum extract on the hypothalamic-pituitary adrenal system in rats. Bull Exp Biol Med 132: 1180–1181

    PubMed  Google Scholar 

  25. Franklin M, Hafizi S, Reed A, Murck H (2004) Effect of sub-chronic treatment with Jarsin (extract of St John’s Wort, Hypericum perforatum) at two dose levels on evening salivary melatonin and cortisol concentrations in healthy male volunteers. Pharmacopsychiatry, in press

    Google Scholar 

  26. Butterweck V, Wall A, Lieflander-Wulf U, Winrehohh H, Nahrstedt A (1997) Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharamacopsychiatry 30(Suppl): 117–124

    Google Scholar 

  27. Rommelspacher H, Siemanowitz B, Mannel M (2001) Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens. Pharmacopsychiatry 34(Suppl 1): S119–126

    PubMed  Google Scholar 

  28. Dimpfel W, Schober F, Mannel M (1998) Effects of a methanolic extract and a hyperforin-enriched extract of St John’s Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-stereo-EEG). Pharmacopsychiatry 31(Suppl 1): 30–35

    Google Scholar 

  29. Arendt J (1985) Mammalian pineal rhythms. Pineal Res Rev 3: 161–213

    Google Scholar 

  30. Butterweck V, Winterhoff H, Herkenham M (2003) Hyperforin-containing extracts of St John’s Wort fail to alter gene transcription in brain areas involved in HPA axis control: a long-term regimen in rats. Neuropsychopharmacology 28: 2160–2168

    PubMed  Google Scholar 

  31. Franklin M, Reed A, Murck H (2004) Sub-chronic treatment with an extract of Hypericum perforatum (St John’s Wort) significantly reduces cortisol and corticosterone in rat brain. Eur Neuropsychopharmacol 14: 7–10

    PubMed  Google Scholar 

  32. Durr D, Steiger B, Kullak-Ublick BA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K (2000) St John’s Wort induces intestinal P-glycoprotein and intestinal and hepatic CYP3A4. Clin Pharmacol Ther 68: 598–604

    PubMed  Google Scholar 

  33. Perloff MD, von Moltke LL, Stormer E, Shader RI, Greenblatt DJ (2001) St John’s Wort: an in vitro analysis of p-glycoprotein induction due to extended exposure. Bt J Pharmacol 134: 1601–1606

    Google Scholar 

  34. Hennessy M, Kellerher D, Spiers JP, Kavanagh P, Back D, Mulcahy F, Feely J (2002) St John’s Wort increases expression of p-glycoprotein: implications for drug interactions. Brit J Clin Pharmacol 53: 75–82

    Google Scholar 

  35. Carroll BJ, Curtis GC, Mendels J (1976) Cerebrospinal fluid and plasma free cortisol concentrations in depression. Psychol Med 6: 235–244

    PubMed  Google Scholar 

  36. Steiger A, Von Bardeleben U, Wiedemann K, Holsboer F (1991) Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major depression during acute phase and remission. J Psychiatr Res 25: 169–177

    PubMed  Google Scholar 

  37. Meltzer HY (1984) Serotonergic function in the affective disorders: the effect of antidepressants and lithium on the 5-HTP-induced increase in serum cortisol. Ann NY Acad Sci 430: 115–137

    PubMed  Google Scholar 

  38. Gartside SE, Ellis PM, Sharp T, Cowen PJ (1992) Selective 5-HT1A and 5-HT2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments. Eur J Pharmacol 221: 103–109

    Google Scholar 

  39. Maj J, Bijak M, Dziedzicka-Waslewska M, Rogoz R, Rogoz Z, Skuza G, Tokarski T (1996) The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat. Psychopharmacology 127: 73–82

    PubMed  Google Scholar 

  40. Raap DK, Van de Kar LD (1999) Selective serotonin re-uptake inhibitors and neuroendocrine function. Life Sci 65: 1217–1235

    PubMed  Google Scholar 

  41. Sargent PA, Williamson DJ, Cowen PJ (1998) brain 5-HT neurotransmission during paroxetine treatment. Brit J Psychiatry 172: 49–52

    Google Scholar 

  42. Arnett CD, Wolf AP, Shine H (1986) Improved delineation of human dopamine receptors using 18F-N-methylspiroperidol and PET. J Nucl Med 27: 1878–1886

    PubMed  Google Scholar 

  43. Ascher JA, Cole JA, Colin JN, Feighner JP, Ferris RM, Fiberger HC, Golden RN, Martin P, Potter WL, Richelson E, Sulser F (1995) A review of its mechanism of antidepressant activity. J Clin Psychiatry 56: 395–401

    PubMed  Google Scholar 

  44. Potter WL (1998) Bipolar depression: specific treatments. J Clin Psychiatry 59: 30–38

    Google Scholar 

  45. Hurt RD, Sachs DPL, Glover ED, Offord KP, Johnson JA, Loweell CD (1997) A comparison of sustained-release bupropion and placebo for smoking cessation. N Engl J Med 337: 1195–1202

    PubMed  Google Scholar 

  46. Butterweck V, Nahrstedt A, Winterhoff H (1998) Effects of Hypericum perforatum extract and isolated constituents on neurotransmitter concentrations and endocrine parameters. Ann Congress of the Soc of Med Plant Res: J29

    Google Scholar 

  47. Laakmann G, Schule C, Baghai T, Waldvogel E (1999) Effects of mirtazapine on growth hormone, prolactin and cortisol secretion in healthy male subjects. Psychoneuroendocrinology 24: 769–784

    PubMed  Google Scholar 

  48. Attenburrow MJ, Mitter PR, Whale R, Terao T, Cowen PJ (2001) Low-dose citalopram as a 5-HT neuroendocrine probe. Psychopharmacology 155: 323–326

    PubMed  Google Scholar 

  49. Schule C, Baghai T, Schmidbauer S, Bidlingmaier M, Strasburger C. Laakmann G (2004) Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects. Psychoneuroendocrinology 29: 185–200

    PubMed  Google Scholar 

  50. Melzer HY, Simonovic M, Sturgeon RD, Fang VS (1981) Effect of antidepressants, lithium and electroconvulsive treatment on rat serum prolactin. Acta Psychiatr Scand Suppl 290: 100–121

    PubMed  Google Scholar 

  51. Burns TG, Brown GM (1985) The effects of acute and chronic desipramine treatment on pineal and serum melatonin and N-acetylserotonin. In: GM Brown, SD Wainwright (eds): The Pineal gland. Pergamon Press, Oxford, UK, 25–30.

    Google Scholar 

  52. Ferko N, Levine MA (2001) Evaluation of the association between St John’s Wort and elevated thyroid-stimulating hormone. Pharmacotherapy 21: 1574–1578

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Birkhäuser Verlag/Switzerland

About this chapter

Cite this chapter

Franklin, M. (2005). Endocrinology of St. John’s Wort extract. In: Müller, W.E. (eds) St. John’s Wort and its Active Principles in Depression and Anxiety. Milestones in Drug Therapy MDT. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7338-5_13

Download citation

Publish with us

Policies and ethics