Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kudoh S, Azuma A, Yamamoto M, Izumi T, Ando M (1998) Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med 157: 1829–32
Yamamoto M, Kudoh S, Ina Y, Tamura A (1990) Clinical efficacy of erythromycin for patients with diffuse panbronchiolitis — a double blind study. Saishin Igaku 45: 103–8
Jaffe A, Bush A (2001) Anti-inflammatory effects of macrolides in lung disease. Pediatr Pulmonol 31: 464–73
Rubin BK (2002) The pharmacologic approach to airway clearance: mucoactive agents. Respir Care 47: 818–22
Majima Y (2002) Mucoactive medications and airway disease. Paediatr Respir Rev 3: 104–9
Goswami SK, Kivity S, Marom Z (1990) Erythromycin inhibits respiratory glycoconjugate secretion from human airways in vitro. Am Rev Respir Dis 141: 72–8
Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y (2003) In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am J Respir Crit Care Med 168: 581–7
Tamaoki J, Takeyama K, Yamawaki I, Kondo M, Konno K (1997) Lipopolysaccharide-induced goblet cell hypersecretion in the guinea pig trachea: inhibition by macrolides. Am J Physiol 272: L15–L19
Tamaoki J, Nakata J, Tagaya E, Konno K (1996) Effects of roxithromycin and erythromycin on interleukin 8-induced neutrophil recruitment and goblet cell secretion in guinea pig tracheas. Antimicrob Agents Chemother 40: 1726–8
Irokawa T, Sasaki T, Shimura S, Sasamori K, Oshiro T, Nara M, Tamada T, Shirato K (1999) Cholinomimetic action of macrolide antibiotics on airway gland electrolyte secretion. Am J Physiol 276: L951–L957
Zuhdi Alimam M, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC (2000) Muc5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 22: 253–60
Takeyama K, Fahy JV, Nadel JA (2001) Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am J Respir Crit Care Med 163: 511–6
Wickstrom C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I (1998) MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J 334: 685–93
Hovenberg HW, Davies JR, Herrmann A, Linden CJ, Carlstedt I (1996) MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions. Glycoconj J 13: 839–47
Davies JR, Svitacheva N, Lannefors L, Kornfalt R, Carlstedt I (1999) Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions. Biochem J 344: 321–30
Kaneko Y, Yanagihara K, Seki M, Kuroki M, Miyazaki Y, Hirakata Y, Mukae H Tomono K, Kadota J, Kohno S (2003) Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis. Am J Physiol Lung Cell Mol Physiol 285: L847–L853
Li JD, Feng W, Gallup M, Kim JH, Gum J, Kim Y, Basbaum C (1998) Activation of NFkappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sci USA 95: 5718–23
Takeyama K, Dabbagh K, Lee HM, Agusti C, Lausier JA, Ueki IF, Grattan KM, Nadel JA (1999) Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 96: 3081–6
Perrais M, Pigny P, Copin MC, Aubert JP, Van Seuningen I (2002) Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem 277: 32258–67
Takeyama K, Tamaoki J, Kondo M, Aoshiba K, Nakata J, Isono K, Nagai A (2001) Effect of macrolide antibiotics on MUC5AC production in human bronchial epithelial cells. Jpn J Antibiot 54: 52–4
Aoki Y, Kao PN (1999) Erythromycin inhibits transcriptional activation of NF-kappaB but not NFAT, through calcineurin-independent signaling in T cells. Antimicrob Agents Chemother 43: 2678–84
Desaki M, Takizawa H, Ohtoshi T, Kasama T, Kobayashi K, Sunazuka T, Omura S, Yamamoto K, Ito K (2000) Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells. Biochem Biophys Res Commun 267: 124–8
Anderson R (1989) Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant-activated superoxide generation and autooxidation. J Infect Dis 159: 966–73
Gorrini M, Lupi A, Viglio S, Pamparana F, Cetta G, Iadarola P, Powers JC, Luisetti M (2001) Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics. Am J Respir Cell Mol Biol 25: 492–9
Tamaoki J, Takeyama K, Tagaya E, Konno K (1995) Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections. Antimicrob Agents Chemother 39: 1688–90
Tagaya E, Tamaoki J, Kondo M, Nagai A (2002) Effect of a short course of clarithromycin therapy on sputum production in patients with chronic airway hypersecretion. Chest 122: 213–18
Rubin BK, Druce H, Ramirez OE, Palmer R (1997) Effect of clarithromycin on nasal mucus properties in healthy subjects and in patients with purulent rhinitis. Am J Respir Crit Care Med 155: 2018–23
Takeyama K, Tamaoki J, Chiyotani A, Tagaya E, Konno K (1993) Effect of macrolide antibiotics on ciliary motility in rabbit airway epithelium in vitro. J Pharm Pharmacol 45:756–8
Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G et al (2001) Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 163: 517–23
Henke MO, Renner A, Huber RM, Seeds MC, Rubin BK (2004) MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions. Am J Respir Cell Mol Biol 31: 86–91
Chu HW, Kraft M, Krause JE, Rex MD, Martin RJ (2000) Substance P and its receptor neurokinin 1 expression in asthmatic airways. J Allergy Clin Immunol 106: 713–22
Shao MX, Ueki IF, Nadel JA (2003) Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci USA 100: 11618–23
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Birkhäuser Verlag Basel/Switzerland
About this chapter
Cite this chapter
Takeyama, K. (2005). Macrolides and mucus production. In: Rubin, B.K., Tamaoki, J. (eds) Antibiotics as Anti-Inflammatory and Immunomodulatory Agents. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7310-5_8
Download citation
DOI: https://doi.org/10.1007/3-7643-7310-5_8
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-5925-6
Online ISBN: 978-3-7643-7310-8
eBook Packages: MedicineMedicine (R0)