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References
Labro MT (1993) Effects of macrolides on host natural defences. In: AJ Bryskier, JP Butzler, HC Neu, PM Tulkens (eds): Macrolides. Arnette Blackwell, Paris, 389–408
Desaki M, Takizawa H, Ohtoshi T, Kasama T, Kobayashi K, Sunazuka T, Omura S, Yamamoto K, Ito K (2000) Erythromycin suppresses nuclear factor-ºB and activator protein-1 activation in human bronchial epithelial cells. Biochem Biophys Res Commun 267: 124–8
Yamanaka A, Saiki S, Tamura S, Saito K (1969) Problems in chronic obstructive bronchial disease, with special reference to diffuse panbronchiolitis. Naika 23: 442–51
Kobayashi H (1995) Airway biofilm disease: clinical manifestations and therapeutic possibilities using macrolides. J Infect Chemother 1: 1–15
Sawaki M, Mikami R, Mikasa K, Kunimatsu M, Ito S, Narita N (1986) The long-term chemotherapy with erythromycin in chronic lower respiratory tract infection — first report: comparison with amoxicillin. Kansenshogaku Zasshi 60: 37–44
Khair OA, Devalia JL, Abdelaziz MM, Sapsford RJ, Davis RJ (1995) Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and sICAM-1 by cultured human bronchial epithelial cells. Eur Respir J 8: 1451–7
Ueda K, Mikasa K, Hamada K, Sakamoto M, Konishi M, Maeda K, Majima T, Kita E, Narita N (1999) Effects of clarithromycin on expression of cytokine mRNA in spleen cells of mice bearing Lewis lung carcinoma cells. Haigan 39: 117–24
Mikasa K, Sawaki M, Konishi M, Egawa S, Yoneda T, Yagyu Y, Fujimura M, Hamada K, Kunimatsu M, Narita N (1989) The effect of erythromycin treatment of natural killer (NK) cell activity in patients with chronic lower respiratory tract infections. Kansenshogaku Zasshi 63: 811–15
Hamada K, Kita E, Sawaki M, Mikasa K, Narita N (1995) Antitumor effect of erythromycin in mice. Chemotherapy 41: 59–69
Hamada K, Mikasa K, Yunou Y, Kurioka T, Majima T, Narita E (2000) Adjuvant effect of clarithromycin on chemotherapy for murine lung cancer. Chemotherapy 46:49–61
Mikasa K, Sawaki M, Kita E, Hamada K, Teramoto S, Sakamoto M, Maeda K, Konishi M, Narita N (1997) Significant survival benefit to patients with advanced non-small-cell lung cancer from treatment with clarithromycin. Chemotherapy 43: 288–96
Sawaki M, Kita E, Mikasa K, Narita N (1995) Clarithromycin as a potent ant-angiogenesis agent: possible application for the antitumor agent. Can J Infect Dis 6(Suppl C):213
Yatsunami J, Tsuruta N, Wakamatsu K. Hara N, Hayashi S (1997) Clarithromycin is a potent inhibitor of tumor-induced angiogenesis. Res Exp Med 197: 189–97
Yatsunami J, Tsuruta N, Fukuno Y, Kawashima M, Taniguchi S, Hayashi S (1999) Inhibitory effects of roxithromycin on tumor angiogenesis, growth and metastasis of mouse B16 melanoma cells. Clin Exp Metastasis 17: 119–24
Parajuli P, Yano S, Hanibuchi M, Nokihara H, Shinohara T, Sone S (1998) Effect of clarithromycin on the distant metastases of human lung cancer cells in SCID mice. J Med Invest 44: 205–10
Teramoto S, Kita E, Mikasa K, Hamada K, Konishi M, Maeda K, Sakamoto M, Tsujimoto M, Mori K, Sawaki M et al (1998) Effect of clarithromycin administration on interferon-gamma and interleukin 12 mRNA expression in the tumor tissue of nonsmall-cell lung cancer. Jpn J Antibiot 51(Suppl): 53–5
Sakamoto M, Mikasa K, Majima T, Hamada K, Konishi M, Maeda K, Kita E, Narita N (2001) Anti-cachectic effect of clarithromycin for patients with unresectable non-small cell lung cancer. Chemotherapy 47: 444–51
Sasaki M, Ito T, Fukui S, Izumiyama N, Kashima M, Sano M, Fujiwara Y, Miura H (2001) Effect of 14-membered ring macrolides on heparanase mRNA expression in lung cancer cells. Jpn J Antibiot (Suppl): 54: C97–100
Sasaki M, Kashima M, Ito T, Watanabe A, Sano M, Kagaya M, Shioya T, Miura M (2000) Effect of heparin and related glycosaminoglycan on PDGF-induced lung fibroblast proliferation, chemotactic response and matrix metalloproteinases activity. Mediators Inflamm 9: 85–91
Lapierre F, Holme K, Lam L, Tressler RJ, Storm N, Wee J, Stack RJ, Castellot J, Tyrrell D (1996) Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties. Glycobiol 6: 355–66
Nakajima M, Irimura T, Nicolson GL (1988) Heparanases and tumor metastasis. J Biol Chem 36: 157–67
Vaday GG, Lider O (2000) Extracellular matrix miotics, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation. J Leukoc Biol 67: 149–59
Nakajima M, Irimura T, Di Ferrante N, Nicolson GL (1984) Metastatic melanoma cell heparanase. Characterization of heparan sulphate degradation fragments produced by B16 melanoma endoglucuronidase. J Biol Chem 259: 2283–90
Vlodavsky I, Friedman Y, Elkin M, Aingorn H, Atzmon R, Ishai-Michaeli R, Bitan M, Pappo O, Peretz T, Michal I et al (1999) Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 5: 793–802
Hulett MD, Freeman C, Hamdorf BJ, Baker RT, Harris MJ, Parish CR (1999) Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. Nat Med 5: 803–9
Kita E, Mikasa K, Kasahara K (2003) Syndecan shedding from epithelial cells affects host defense against respiratory infection. International Congress Series 1257C:21–5
Joensuu H, Anttonen A, Eriksson M, Mäkitaro R, Alfthan H, Kinnula V, Leppä S (2002) Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer. Cancer Res 62: 5210–17
Anttonen A, Leppa S, Ruotsalainen T, Alfthan H, Mattson K, Joensuu H (2003) Pretreatment serum syndecan-1 levels and outcome in small cell lung cancer patients treated with platinum-based chemotherapy. Lung Cancer 41: 171–7
Tsutsumi M, Kitada H, Shiraiwa K, Takahama M, Tsujiuchi T, Sakitani H, Sasaki Y, Murakawa K, Yoshimoto M, Konishi Y (2000) Inhibitory effects of combined administration of antibiotics and anti-inflammatory drugs on lung tumor development initiated by N-nitrosobis (2-hydroxypropyl) amine in rats. Carcinogenesis 21: 251–6
Li Q, Park PW, Wilson CL, Parks WC (2002) Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111: 635–46
Tjan-Heijnen VCG, Postmus PE, Ardizzoni A, Manegold CH, Burghouts J, van Meerbeeck J, Gans S, Mollers M, Buchholz E, Biesma B et al (2001) Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients: an EORTC double-blind placebo-controlled phase III study. Ann Oncol 12: 1359–68
Alder J, Mitten M, Jarvis K, Gupta P, Clement J (1993) Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. Antimicrob Agents Chemother 37:1329–33
Tissi L, von Hunolstein C, Mosci P, Campanelli C, Bistoni F, Orefici G (1995) In vivo efficacy of azithromycin in treatment of systemic infection and septic arthritis induced by type IV group B Streptococcus strain in mice: comparative study with erythromycin and penicillin G. Antimicrob Agents Chemother 39: 1938–47
Carevic O, Djokic S (1988) Comparative studies on the effects of erythromycin A and azithromycin upon extracellular release of lysosomal enzymes in inflammatory processes. Agents Actions 25: 124–31
Mikasa K, Kita E, Sawaki M, Kunimatsu M, Hamada K, Konishi M, Kashiba S, Narita N (1992) The anti-inflammatory effect of erythromycin in zymosan-induced peritonitis of mice. J Antimicrob Chemother 30: 339–48
Kadota J, Sakito O, Kohno S, Sawa H, Mukae H, Oda H, Kawakami K, Fukushima K, Hiratani K, Hara K (1993) A mechanism of erythromycin treatment in patients with diffuse panbronchiolitis. Am Rev Respir Dis 147: 153–9
Takizawa H, Desaki M, Ohtoshi T, Kawasaki S, Kohyama T, Sato M, Tanaka M, Kasama T, Kobayashi K, Nakajima J et al (1997) Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. Am J Respir Crit Care Med 156: 266–71
Takizawa H, Desaki M, Ohtoshi T, Kikutani S, Okazaki H, Sato M, Tanaka M, Akiyama N, Shoji S, Hiramatsu K et al (1995) Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: A potential mechanism of its anti-inflammatory action. Biochem Biophys Res Commun 210: 781–6
Matsuoka N, Eguchi K, Kawakami A, Tsuboi M, Kawabe Y, Aoyagi T, Nagataki S (1996) Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. Clin Exp Immunol 104: 501–8
Saviola G, Abdi Ali L, Rossini P, Campostrini L, Coppini A, Gori M, Ianaro A, Bucci M, de Nucci G, Cirino G (2002) Clarithromycin in rheumatoid arthritis patients not responsive to disease-modifying antirheumatic drugs: an open, uncontrolled pilot study. Clin Exp Rheumatol 20: 373–8
Nishimoto N, Sasai M, Shima Y, Nakagawa M, Matsumoto T, Shirai T, Kishimoto T, Yoshizaki K (2000) Improvement in Castleman’s disease by humanized anti-interleukin-6 receptor antibody therapy. Blood 95: 56–61
Yoshizaki K, Nishimoto N, Mihara M, Kishimoto T (1998) Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Springer Semin Immunopathol 20: 247–59
Mahmoud MS, Ishikawa H, Fujii R, Kawano MM (1988) Induction of CD45 Expression and Proliferation in U-266 myeloma cell line by interleukin-6 (IL-6). Blood 92: 3887–97
Liu Y, van Kruiningen HJ, West AB, Cartun RW, Cortot A, Colombel JF (1995) Immunocytochemical evidence of Listeria, Escherichia coli, and Streptococcus antigens in Crohn’s disease. Gastroenterology 108: 1396–404
Cartun RW, Van Kruiningen HJ, Pedersen CA, Berman MM (1993) An immunocytochemical search for infectious agents in Crohn’s disease. Mod Pathol 6: 212–19
Hermon-Tayler J, Barnes N, Clarke C, Finlayson C (1998) Mycobacterium paratuberculosis cervical lymphadenitis, followed five years later by terminal ileitis similar to Crohn’s disease. Br Med J 316: 449–53
Dell’Isola B, Poyart C, Goulet O, Mougenot JF, Sadoun-Journo E, Brousse N, Schmitz J, Ricour C, Berche P (1994) Detection of Mycobacterium paratuberculosis by polymerase chain reaction in children with Crohn’s disease. J Infect Dis 169: 449–51
Millar D, Ford J, Sanderson J, Withey S, Tizard M, Doran T, Hermon-Taylor J (1996) IS900 PCR to detect Mycobacterium paratuberculosis in retail supplies of whole pasteurized cows’ milk in England and Wales. Appl Environ Microbiol 62: 3446–52
Swift GL, Srivastava ED, Stone R, Pullan RD, Newcombe RG, Rhodes J, Wilkinson S, Rhodes P, Roberts G, Lawrie BW (1994) Controlled trial of anti-tuberculous chemotherapy for two years in Crohn’s disease. Gut 35: 363–8
Gui GP, Thomas PR, Tizard ML, Lake J, Sanderson JD, Hermon-Taylor J (1997) Two-year-outcomes analysis of Crohn’s disease treated with rifabutin and macrolide antibiotics. J Antimicrob Chemother 39: 393–400
Day R, Forbes A (1999) Heparin, cell adhesion, and pathogenesis of inflammatory bowel disease. Lancet 354: 62–5
Day R, Ilyas M, Daszak P, Talbot I, Forbes A (1999) Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy. Dig Dis Sci 44: 2508–15
Colgan SP, Comerford KM, Lawrence DW (2002) Epithelial cell-neutrophil interactions in the alimentary tract: a complex dialog in mucosal surveillance and inflammation. The Scientific World Journal 2: 76–88
Tanabe H, Yokota K, Kohgo Y (1999) Localization of syndecan-1 in human gastric mucosa associated with ulceration. J Pathol 187: 338–44
Kuzin II, Snyder JE, Ugine GD, Wu D, Lee S, Bushnell T Jr, Insel RA, Young MF, Bottaro A (2001) Tetracyclines inhibit activated B cell function. Int Immunol 12: 921–931
Amin AR, Attur MG, Thakker GD, Patel PD, Vyas PR, Patel RN, Patel IR, Abramson SB (1996) A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 93: 14014–19
Amin AR, Patel RN, Thakker GD, Lowenstein CJ, Attur MG, Abramson SB (1997) Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett 410:259–64
Pruzanski W, Greenwald RA, Street IP, Laliberte F, Stefanski E, Vadas P (1992) Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline. Biochem Pharmacol 44: 1165–70
Shapira L, Soskolne WA, Houri Y, Barak V, Halabi A, Stabholz A (1996) Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infect Immun 64: 825–8
Liu J, Kuszynski CA, Baxter BT (1999) Doxycycline induces Fas/Fas ligand-mediated apoptosis in Jurkat T lymphocytes. Biochem Biophys Res Commun 260: 562–7
Vernillo AT, Rifkin BR (1998) Effects of tetracyclines on bone metabolism. Adv Dental Res 12: 56–62
Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T (1998) Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dental Res 12: 12–6
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Mikasa, K., Kasahara, K., Kita, E. (2005). Macrolides and cancer, arthritis and IBD. In: Rubin, B.K., Tamaoki, J. (eds) Antibiotics as Anti-Inflammatory and Immunomodulatory Agents. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7310-5_15
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