This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Richards MJ, Edwards JR, Culver DH, Gaynes RP (1999) Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med 27(5): 887–92
Hoiby N (1994) Diffuse panbronchiolitis and cystic fibrosis: East meets West. Thorax 49(6): 531–2
Wilson R, Dowling RB (1998) Lung infections. 3. Pseudomonas aeruginosa and other related species. Thorax 53(3): 213–19
Passador L, Cook JM, Gambello MJ, Rust L, Iglewski BH (1993) Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260(5111): 1127–30
Kaplan HB, Greenberg EP (1985) Diffusion of autoinducer is involved in regulation of the Vibrio fischeri luminescence system. J Bacteriol 163(3): 1210–14
Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP (1994) Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci USA 91(1): 197–201
Pearson JP, Passador L, Iglewski BH, Greenberg EP (1995) A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc Natl Acad Sci USA 92(5):1490–4
Kudoh S, Kimura H (1984) Clinical effect of low-dose long-term administration of macrolides on diffuse panbronchiolits. Jpn J Thorac Dis 22: 254
Kudoh S, Uetake T, Hagiwara K, Hirayama M, Hus LH, Kimura H, Sugiyama Y (1987) Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis. Jpn J Thorac Dis 25(6): 632–42
Peters DH, Friedel HA, McTavish D (1992) Azithromycin: A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. Drugs 44(5): 750–99
Wilson JT, van Boxtel CJ (1978) Pharmacokinetics of erythromycin in man. Antibiot Chemother 25: 181–203
Kirst HA, Sides GD (1989) New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy. Antimicrob Agents Chemother 33(9): 1419–22
Butts JD (1994) Intracellular concentrations of antibacterial agents and related clinical implications. Clin Pharmacokinet 27(1): 63–84
Tulkens PM (1991) Intracellular distribution and activity of antibiotics. Eur J Clin Microbiol Infect Dis 10(2): 100–106
Gladue RP, Bright GM, Isaacson RE, Newborg MF (1989) In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother 33(3): 277–82
Tateda K, Ishii Y, Matsumoto T, Furuya N, Nagashima M, Matsunaga T, Ohno A, Miyazaki S, Yamaguchi K (1996) Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. Antimicrob Agents Chemother 40(10): 2271–5
Pollack M (1984) The virulence of Pseudomonas aeruginosa. Rev Infect Dis 6(Suppl 3):S617–626
Molinari G, Paglia P, Schito GC (1992) Inhibition of motility of Pseudomonas aeruginosa and Proteus mirabilis by subinhibitory concentrations of azithromycin. Eur J Clin Microbiol Infect Dis 11(5): 469–71
Molinari G, Guzman CA, Pesce A, Schito GC (1993) Inhibition of Pseudomonas aeruginosa virulence factors by subinhibitory concentrations of azithromycin and other macrolide antibiotics. J Antimicrob Chemother 31(5): 681–8
Sato K, Suga M, Nishimura J, Kushima Y, Muranaka H, Ando M (1997) Pyocyanine synthesis by Pseudomonas aeruginosa in chronic airway infection and the effect of erythromycin on its biological activity. Jpn J Antibiot 50(Suppl): 89–91
Kita E, Sawaki M, Oku D, Hamuro A, Mikasa K, Konishi M, Emoto M, Takeuchi S, Narita N, Kashiba S (1991) Suppression of virulence factors of Pseudomonas aeruginosa by erythromycin. J Antimicrob Chemother 27(3): 273–84
Sakata K, Yajima H, Tanaka K, Sakamoto Y, Yamamoto K, Yoshida A, Dohi Y (1993) Erythromycin inhibits the production of elastase by Pseudomonas aeruginosa without affecting its proliferation in vitro. Am Rev Respir Dis 148(4 Pt 1): 1061–5
Hirakata Y, Kaku M, Mizukane R, Ishida K, Furuya N, Matsumoto T, Tateda K, Yamaguchi K (1992) Potential effects of erythromycin on host defense systems and virulence of Pseudomonas aeruginosa. Antimicrob Agents Chemother 36(9): 1922–7
Mizukane R, Hirakata Y, Kaku M, Ishii Y, Furuya N, Ishida K, Koga H, Kohno S, Yamaguchi K (1994) Comparative in vitro exoenzyme-suppressing activities of azithromycin and other macrolide antibiotics against Pseudomonas aeruginosa. Antimicrob Agents Chemother 38(3): 528–33
Govan JR, Deretic V (1996) Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 60(3): 539–74
Yasuda H, Ajiki Y, Koga T, Kawada H, Yokota T (1993) Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. Antimicrob Agents Chemother 37(9): 1749–55
Ichimiya T, Yamasaki T, Nasu M (1994) In-vitro effects of antimicrobial agents on Pseudomonas aeruginosa biofilm formation. J Antimicrob Chemother 34(3): 331–41
Ichimiya T, Takeoka K, Hiramatsu K, Hirai K, Yamasaki T, Nasu M (1996) The influence of azithromycin on the biofilm formation of Pseudomonas aeruginosa in vitro. Chemotherapy 42(3): 186–91
Kobayashi H (1995) Biofilm disease: its clinical manifestation and therapeutic possibilities of macrolides. Am J Med 99(6A): 26S–30S
Ripoll L, Reinert P, Pepin LF, Lagrange PH (1996) Interaction of macrolides with alpha dornase during DNA hydrolysis. J Antimicrob Chemother37(5): 987–91
Menninger JR, Coleman RA, Tsai LN (1994) Erythromycin, lincosamides, peptidyl-tRNA dissociation, and ribosome editing. Mol Gen Genet 243(2): 225–33
Tateda K, Ishii Y, Hirakata Y, Matsumoto T, Ohno A, Yamaguchi K (1994) Profiles of outer membrane proteins and lipopolysaccharide of Pseudomonas aeruginosa grown in the presence of sub-MICs of macrolide antibiotics and their relation to enhanced serum sensitivity. J Antimicrob Chemother 34(6): 931–42
Tateda K, Hirakata Y, Furuya N, Ohno A, Yamaguchi K (1993) Effects of sub-MICs of erythromycin and other macrolide antibiotics on serum sensitivity of Pseudomonas aeruginosa. Antimicrob Agents Chemother 37(4): 675–80
Shibl AM (1985) Effect of antibiotics on adherence of microorganisms to epithelial cell surfaces. Rev Infect Dis 7(1): 51–65
Yamasaki T, Ichimiya T, Hirai K, Hiramatsu K, Nasu M (1997) Effect of antimicrobial agents on the piliation of Pseudomonas aeruginosa and adherence to mouse tracheal epithelium. J Chemother 9(1): 32–7
Kawamura-Sato K, Iinuma Y, Hasegawa T, Horii T, Yamashino T, Ohta M (2000) Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis. Antimicrob Agents Chemother 44(10): 2869–72
Saiman L, Chen Y, Gabriel PS, Knirsch C (2002) Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis. Antimicrob Agents Chemother 46(4): 1105–7
Bui KQ, Banevicius MA, Nightingale CA, Quintiliani R, Nicolau DP (2000) In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa. J Antimicrob Chemother 45(1): 57–62
Yanagihara K, Tomono K, Sawai T, Kuroki M, Kaneko Y, Ohno H, Higashiyama Y, Miyazaki Y, Hirakata Y, Maesaki S et al (2000) Combination therapy for chronic Pseudomonas aeruginosa respiratory infection associated with biofilm formation. J Antimicrob Chemother 46(1): 69–72
Tateda K, Ishii Y, Matsumoto T, Kobayashi T, Miyazaki S, Yamaguchi K (2000) Potential of macrolide antibiotics to inhibit protein synthesis of Pseudomonas aeruginosa: suppression of virulence factors and stress response. J Infect Chemother 6(1): 1–7
Lam J, Chan R, Lam K, Costerton JW (1980) Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis. Infect Immun 28(2):546–56
Gilligan PH (1991) Microbiology of airway disease in patients with cystic fibrosis. Clin Microbiol Rev 4(1): 35–51
Gambello MJ, Iglewski BH (1991) Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol 173(9): 3000–9
Ochsner UA, Koch AK, Fiechter A, Reiser J (1994) Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J Bacteriol 176(7): 2044–54
Rumbaugh KP, Griswold JA, Iglewski BH, Hamood AN (1999) Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun 67(11): 5854–62
Pearson JP, Feldman M, Iglewski BH, Prince A (2000) Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect Immun 68(7): 4331–4
Smith RS, Harris SG, Phipps R, Iglewski BH (2002) The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol 184(4): 1132–9
Wu H, Song Z, Givskov M, Doring G, Worlitzsch D, Mathee K, Rygaard J, Hoiby N (2001) Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection. Microbiology 147 (Pt 5): 1105–13
Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP (2000) Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407(6805): 762–4
Parsek MR, Greenberg EP (1999) Quorum sensing signals in development of Pseudomonas aeruginosa biofilms. Methods Enzymol 310: 43–55
Parsek MR, Greenberg EP (2000) Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc Natl Acad Sci USA 97(16): 8789–93
De Kievit TR, Iglewski BH (1999) Quorum sensing, gene expression, and Pseudomonas biofilms. Methods Enzymol 310: 117–28
Sauer K, Camper AK, Ehrlich GD, Costerton JW, Davies DG (2002) Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol 184(4): 1140–54
Storey DG, Ujack EE, Rabin HR, Mitchell I (1998) Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis. Infect Immun 66(6): 2521–8
Erickson DL, Endersby R, Kirkham A, Stuber K, Vollman DD, Rabin HR, Mitchell I, Storey DG (2002) Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect Immun 70(4):1783–90
Charlton TS, de Nys R, Netting A, Kumar N, Hentzer M, Givskov M, Kjelleberg S (2000) A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm. Environ Microbiol 2(5): 530–41
DiMango E, Zar HJ, Bryan R, Prince A (1995) Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 96(5): 2204–10
Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP (2001) IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol 167(1): 366–74
Tateda K, Ishii Y, Horikawa M, Matsumoto T, Miyairi S, Pechere JC, Standiford TJ, Ishiguro M, Yamaguchi K (2003) The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils. Infect Immun 71(10): 5785–93
de Kievit TR, Iglewski BH (2000) Bacterial quorum sensing in pathogenic relationships. Infect Immun 68(9): 4839–49
Miller MB, Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55:165–99
Whitehead NA, Barnard AM, Slater H, Simpson NJ, Salmond GP (2001) Quorum-sensing in Gram-negative bacteria. FEMS Microbiol Rev 25(4): 365–404
Schauder S, Bassler BL (2001) The languages of bacteria. Genes Dev 15(12): 1468–80
Reverchon S, Chantegrel B, Deshayes C, Doutheau A, Cotte-Pattat N (2002) New synthetic analogues of N-acyl homoserine lactones as agonists or antagonists of transcriptional regulators involved in bacterial quorum sensing. Bioorg Med Chem Lett 12(8): 1153–7
Smith KM, Bu Y, Suga H (2003) Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs. Chem Biol 10(1): 81–9
Hentzer M, Wu H, Andersen JB, Riedel K, Rasmussen TB, Bagge N, Kumar N, Schembri MA, Song Z, Kristoffersen P et al (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. Embo J 22(15): 3803–15
Tateda K, Comte R, Pechere JC, Kohler T, Yamaguchi K, Van Delden C (2001) Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents Chemother 45(6): 1930–3
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Birkhäuser Verlag Basel/Switzerland
About this chapter
Cite this chapter
Tateda, K., Standiford, T.J., Yamaguchi, K. (2005). Effects of antibiotics on Pseudomonas aeruginosa virulence factors and quorum-sensing system. In: Rubin, B.K., Tamaoki, J. (eds) Antibiotics as Anti-Inflammatory and Immunomodulatory Agents. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7310-5_1
Download citation
DOI: https://doi.org/10.1007/3-7643-7310-5_1
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-5925-6
Online ISBN: 978-3-7643-7310-8
eBook Packages: MedicineMedicine (R0)