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Baclofen: clinical data

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Drugs for Relapse Prevention of Alcoholism

Part of the book series: Milestones in Drug Therapy MDT ((MDT))

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References

  1. McGinnis JM, Foege WH (1993) Actual causes of death in the United States. JAMA 270: 2207–2212

    Article  PubMed  CAS  Google Scholar 

  2. Hupkens C, Knibbe R, Drop M (1993) Alcohol consumption in the European Community: uniformity and diversity in drinking patterns. Addiction 88: 1391–1404

    PubMed  CAS  Google Scholar 

  3. Allan AM, Harris A (1989) A new alcohol antagonist: Phaclofen. Life Sci 45: 1771–1779

    Article  PubMed  CAS  Google Scholar 

  4. Davidoff RA (1985) Antispasticity drugs: mechanisms of action. Ann Neurol 17: 107–116

    Article  PubMed  CAS  Google Scholar 

  5. Carai MAM, Agabio R, Addolorato G, Gessa GL, Colombo G (2004) Baclofen: preclinical data. In: R Spanagel, K Mann (eds): Drug for Relapse Prevention of Alcoholism. Birkhäuser, Basel, 163–170

    Google Scholar 

  6. Addolorato G, Viaggi M, Gentilini L, Castelli E, Nicastro P, Stefanini GF, Gasbarrini G (1993) Alcohol addiction: evaluation of the therapeutic effectiveness of self-help group in the maintenance of abstinence from alcohol. Alcologia Eur J Alcohol Stud 5: 261–263

    Google Scholar 

  7. Caputo F, Addolorato G, Dall’Aglio C, Baudanza P, Bernardi M, Gasbarrini G, Stefanini GF (1998) Are brief and long-term alcohol intervention really defined? Addiction 93: 1104

    Google Scholar 

  8. Garbutt JC, West SL, Carey T, Lohr, Crews FT (1999) Pharmacological treatment of alcohol dependence: a review of the evidence. JAMA 14: 1318–1325

    Google Scholar 

  9. Addolorato G, Armuzzi A, Gasbarrini G and Alcoholism Treatment Study Group (2002) Pharmacological approaches to the management of alcohol addiction. Eur Rev Med Pharmacol Sci 6: 89–97

    PubMed  CAS  Google Scholar 

  10. Krupitsky EM, Burakov AM, Ivanov VB, Krandashova GF, Lapin IP, Grinenko A, Borodkin Yu S (1993) Baclofen administration for the treatment of effective disorders in alcoholic patients. Drug Alcohol Depend 33(2): 157–163

    PubMed  CAS  Google Scholar 

  11. Addolorato G, Caputo F, Capristo E, Colombo G, Gessa GL, Gasbarrini G (2000) Ability of baclofen in reducing alcohol craving and intake: II-preliminary clinical evidence. Alcohol Clin Exp Res 24: 67–71

    Google Scholar 

  12. Addolorato G, Caputo F, Capristo E, Domenicali M, Bernardi M, Janiri L, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002) Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcoholism 37: 504–508

    Article  CAS  Google Scholar 

  13. Janiri L, Calvosa F, Dario T, Ruggeri A, Pozzi G, Addolorato G, De Risio S (2004) The Italian version of the obsessive-compulsive drinking scale: validation, comparison with the other versions and difference between type 1-and type 2-like alcoholics. Drug Alcohol Dep 74: 187–195

    Google Scholar 

  14. Anton RF, Moak DH, Latham P (1995) The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior. Alcohol Clin Exp Res 19: 92–99

    PubMed  CAS  Google Scholar 

  15. Addolorato G, Caputo F, Capristo E, Janiri L, Bernardi M, Agabio R, Colombo G, Gessa GL, Gasbarrini G (2002) Rapid suppression of alcohol withdrawal syndrome by baclofen. Am J Med 112: 226–229

    Article  PubMed  Google Scholar 

  16. Addolorato G, Leggio L, Abenavoli L, DeLorenzi G, Parente A, Caputo F, Janiri L, Capristo E, Rapaccini GL, Gasbarrini G (2003) Suppression of alcohol delirium tremens by baclofen administration: a case report. Clin Neuropharmacol 26: 258–262

    PubMed  Google Scholar 

  17. O’Connor PG, Schotternfeld RS (1998) Patients with alcohol problems. N Engl J Med 338: 592–602

    PubMed  CAS  Google Scholar 

  18. Krystal JH, Mc Dougle CJ, Kosten TR, Price LH, Aghajanian GK, Charney DS (1992) Baclofenassisted detoxification from opiates. A pilot study. J Subst Abuse Treat 9: 139–142

    Article  PubMed  CAS  Google Scholar 

  19. Ahmadi-Abhari SA, Akhondzadeh S, Assadi SM, Shabestari OL, Farzanehgan ZM, Kamlipour A (2001) Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspects: a double-blind randomized controlled trial. J Clin Pharm Ther 26: 67–71

    Article  PubMed  CAS  Google Scholar 

  20. Akhondzadeh S, Ahmadi-Abhari SA, Assadi SM, Shabestari OL, Kashani AR, Farzanehgan ZM (2000) Double-bind randomized controlled trial of baclofen versus clonidine in the treatment of opiate withdrawal. J Clin Pharm Ther 25: 347–353

    PubMed  CAS  Google Scholar 

  21. Assadi SM, Radgoodarzi R, Ahmadi-Abhari SA (2003) Baclofen for maintenance tretment of opioid dependence: a randomized double-blind placebo-controlled clinical trial. BMC Psychiatry 3: 16

    Article  PubMed  Google Scholar 

  22. Kalivas PW and Stewart J (1994) Dopamine transmission in the initiation and expression of drug and stress-induced sensitization of motor activity. Brain Res Rev 16: 223–244

    Google Scholar 

  23. Brebner K, Childress AR, Roberts DC (2002) A potential role for GABA (B) agonists in the treatment of psychostimulant addiction. Alcohol Alcoholism 37: 478–484

    Article  CAS  Google Scholar 

  24. Shoptaw S, Yang X, Rotheram-Fuller EJ, Hsieh YC, Charuvastra VC, Ling W (2003) Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individual with chronic patterns of cocaine use. J Clin Psy 64: 1440–1448

    CAS  Google Scholar 

  25. Lile JA, Stoops WW, Allen TS, Glaser PE, Hays LR, Rush CR (2004) Baclofen does not alter the reinforcing, subject-rated or cardiovascular effects of intranasal cocaine in humans. Psychopharmacology 171: 441–449

    Article  PubMed  CAS  Google Scholar 

  26. Carrigall WA, Coen KM, Adamson KL, Chow BL, Zhang J (2000) Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental area. Psychopharmacology 149: 107–114

    Google Scholar 

  27. Cousins MS, Stamat HM, de Wit H (2001) Effects of a single dose of baclofen on self-reported subjective effects and tobacco smoking. Nicotine Tob Res 3: 409

    Article  Google Scholar 

  28. Cousins MS, Roberts DCS, de Wit H (2002) GABAB receptor agonist for the treatment of drug addiction: a review of recent findings. Dug Alcohol Dep 65: 209–220

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Internal Medicine, Catholic University, Gemelli Hospital, L.go A. Gemelli 8, 00168, Rome, Italy

    Giovanni Addolorato, Ludovico Abenavoli, Lorenzo Leggio, Giosuè DeLorenzi, Anna Ferrulli & Giancarlo Colombo

  2. “G. Fontana”, Center for the Study and Treatment of Alcohol Addiction, University of Bologna, Bologna, Italy

    Fabio Caputo & Giovanni Gasbarrini

  3. Department of Neuroscience, University of Cagliari, Cagliari, Italy

    Roberta Agabio & Gian Luigi Gessa

  4. C.N.R. Institute of Neuroscience, c/o “Bernard B. Brodie” Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126, Cagliari, Italy

    Gian Luigi Gessa

Authors
  1. Giovanni Addolorato
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  2. Ludovico Abenavoli
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  3. Lorenzo Leggio
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  4. Giosuè DeLorenzi
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  5. Anna Ferrulli
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  6. Fabio Caputo
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  7. Roberta Agabio
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  8. Gian Luigi Gessa
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  9. Giancarlo Colombo
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  10. Giovanni Gasbarrini
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Editor information

Editors and Affiliations

  1. Abteilung für Psychopharmakologie, Universit ät Heidelberg, J5, Zentralinstitut für Seelische Gesundheit, 68159, Mannheim, Germany

    Rainer Spanagel

  2. Klinik für Abhängiges Verhalten und Suchtmedizin, J5, Zentralinstitut für Seelische Gesundheit, 68159, Mannheim, Germany

    Karl F. Mann

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© 2005 Birkhäuser Verlag/Switzerland

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Addolorato, G. et al. (2005). Baclofen: clinical data. In: Spanagel, R., Mann, K.F. (eds) Drugs for Relapse Prevention of Alcoholism. Milestones in Drug Therapy MDT. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7305-9_16

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