Skip to main content

Potential for manipulation of regulatory T cells in treatment or prevention of allergic disease

  • Chapter
  • 509 Accesses

Part of the book series: Progress in Inflammation Research ((PIR))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Holgate ST (2004) The epidemic of asthma and allergy. J R Soc Med 97: 103–110

    PubMed  Google Scholar 

  2. Law AW, Reed SD, Sundy JS, Schulman KA (2003) Direct costs of allergic rhinitis in the United States: estimates from the 1996 Medical Expenditure Panel Survey. J Allergy Clin Immunol 111: 296–300

    PubMed  Google Scholar 

  3. Smith DH, Malone DC, Lawson KA, Okamoto LJ, Battista C, Saunders WB (1997) A national estimate of the economic costs of asthma. Am J Respir Crit Care Med 156:787–793

    PubMed  Google Scholar 

  4. Kay AB (2001) Allergy and allergic diseases. First of two parts. N Engl J Med 344:30–37

    PubMed  Google Scholar 

  5. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348–2357

    PubMed  Google Scholar 

  6. Wierenga EA, Snoek M, de Groot C, Chretien I, Bos JD, Jansen HM, Kapsenberg ML (1990) Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients. J Immunol 144: 4651–4656

    PubMed  Google Scholar 

  7. Parronchi P, Macchia D, Piccinni MP, Biswas P, Simonelli C, Maggi E, Ricci M, Ansari AA, Romagnani S (1991) Allergen-and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 88: 4538–4542

    PubMed  Google Scholar 

  8. Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173

    PubMed  Google Scholar 

  9. Bonecchi R, Bianchi G, Bordignon PP, D’Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Thls) and Th2s. J Exp Med 187: 129–134

    PubMed  Google Scholar 

  10. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187: 875–883

    PubMed  Google Scholar 

  11. Sallusto F, Mackay CR, Lanzavecchia A (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277: 2005–2007

    PubMed  Google Scholar 

  12. Lohning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC, Levinson D, Radbruch A, Kamradt T (1998) T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA 95:6930–6935

    PubMed  Google Scholar 

  13. DeKruyff RH, Turner T, Abrams JS, Palladino MA, Umetsu DT (1989) Induction of human IgE synthesis by CD4+ T cell clones. Requirement for interleukin 4 and low molecular weight B cell growth factor. J Exp Med 170: 1477–1493

    PubMed  Google Scholar 

  14. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR, Kay AB (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl Med 326: 298–304

    Google Scholar 

  15. van Reijsen FC, Bruijnzeel-Koomen CA, Kalthoff FS, Maggi E, Romagnani S, Westland JK, Mudde GC (1992) Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis. J Allergy Clin Immunol 90: 184–193

    PubMed  Google Scholar 

  16. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC Jr (1992) Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 146: 109–115

    PubMed  Google Scholar 

  17. Robinson D S, Ying S, Bentley AM, Meng Q, North J, Durham SR, Kay AB, Hamid Q (1993) Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J Allergy Clin Immunol 92: 397–403

    PubMed  Google Scholar 

  18. Huang SK, Xiao HQ, Kleine-Tebbe J, Paciotti G, Marsh DG, Lichtenstein LM, Liu MC (1995) IL-13 expression at the sites of allergen challenge in patients with asthma. J Immunol 155:2688–2694

    PubMed  Google Scholar 

  19. Till S, Durham S, Dickason R, Huston D, Bungre J, Walker S, Robinson D, Kay AB, Corrigan C (1997) IL-13 production by allergen-stimulated T cells is increased in allergic disease and associated with IL-5 but not IFN-gamma expression. Immunology 91:53–57

    PubMed  Google Scholar 

  20. Till S, Dickason R, Huston D, Humbert M, Robinson D, Larche M, Durham S, Kay AB, Corrigan C (1997) IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease. J Allergy Clin Immunol 99: 563–569

    PubMed  Google Scholar 

  21. Nakajima H, Iwamoto I, Tomoe S, Matsumura R, Tomioka H, Takatsu K, Yoshida S (1992) CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis 146: 374–377

    PubMed  Google Scholar 

  22. Gavett SH, Chen X, Finkelman F, Wills-Karp M (1994) Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol 10: 587–593

    PubMed  Google Scholar 

  23. Cohn L, Tepper JS, Bottomly K (1998) IL-4-independent induction of airway hyperre-sponsiveness by Th2, but not Thl, cells. J Immunol 161: 3813–3816

    PubMed  Google Scholar 

  24. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JM, Locksley RM (1996) Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med 183: 109–117

    PubMed  Google Scholar 

  25. Coyle AJ, Le Gros G, Bertrand C, Tsuyuki S, Heusser CH, Kopf M, Anderson GP (1995) Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cell Mol Biol 13: 54–59

    PubMed  Google Scholar 

  26. Herrick CA, MacLeod H, Glusac E, Tigelaar RE, Bottomly K (2000) Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. J Clin Invest 105: 765–775

    PubMed  Google Scholar 

  27. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG (1996) Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 183: 195–201

    PubMed  Google Scholar 

  28. Lee JJ, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE, Brenneise IE, Horton MA, Haczku A, Gelfand EW et al (1997). Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med 185: 2143–2156

    PubMed  Google Scholar 

  29. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261–2263

    PubMed  Google Scholar 

  30. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD (1998) Interleukin-13: central mediator of allergic asthma. Science 282: 2258–2261

    PubMed  Google Scholar 

  31. Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buckley MG, Walls AF Askenase PW, Kay AB (1999) C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 163: 3976–3984

    PubMed  Google Scholar 

  32. Larche M, Till SJ, Haselden BM, North J, Barkans J, Corrigan CJ, Kay AB, Robinson DS (1998) Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics. J Immunol 161: 6375–6382

    PubMed  Google Scholar 

  33. Palframan RT, Collins PD, Severs NJ, Rothery S, Williams TJ, Rankin SM (1998) Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med 188: 1621–1632

    PubMed  Google Scholar 

  34. Levings MK, Sangregorio R, Roncarolo MG (2001) Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193: 1295–1302

    PubMed  Google Scholar 

  35. Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH (2001) Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 193: 1285–1294

    PubMed  Google Scholar 

  36. Taams LS, Smith J, Rustin MH, Salmon M, Poulter LW, Akbar AN (2001) Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 31: 1122–1131

    PubMed  Google Scholar 

  37. Dieckmann D, Plottner H, Berchtold S, Berger T, Schuler G (2001) Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 193: 1303–1310

    PubMed  Google Scholar 

  38. Stephens LA, Mottet C, Mason D, Powrie F (2001) Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 31:1247–1254

    PubMed  Google Scholar 

  39. Ng WF, Duggan PJ, Ponchel F Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI (2001) Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood 98: 2736–2744

    PubMed  Google Scholar 

  40. Baecher-Allan C, Brown JA, Freeman GJ, Hafler DA (2001) CD4+CD25 high regulatory cells in human peripheral blood. J Immunol 167: 1245–1253

    PubMed  Google Scholar 

  41. Taams LS, Vukmanovic-Stejic M, Smith J, Dunne PJ, Fletcher JM, Plunkett FJ, Ebeling SB, Lombardi G, Rustin MH, Bijlsma JW et al (2002) Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur J Immunol 32: 1621–1630

    PubMed  Google Scholar 

  42. van Maurik A, Herber M, Wood KJ, Jones ND (2002) Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J Immunol 169: 5401–5404

    PubMed  Google Scholar 

  43. Lin CY, Graca L, Cobbold SP, Waldmann H (2002) Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. Nat Immunol 3: 1208–1213

    PubMed  Google Scholar 

  44. Piccirillo CA, Shevach EM (2001) Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 167: 1137–1140

    PubMed  Google Scholar 

  45. Chen J, Huoam C, Plain K, He XY, Hodgkinson SJ, Hall BM (2001) CD4(+), CD25(+) T cells as regulators of alloimmune responses. Transplant Proc 33: 163–164

    PubMed  Google Scholar 

  46. Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S (2000) Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 192: 303–310

    PubMed  Google Scholar 

  47. Read S, Malmstrom V, Powrie F (2000) Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 192: 295–302

    PubMed  Google Scholar 

  48. McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M, Byrne MC (2002) CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16: 311–323

    PubMed  Google Scholar 

  49. Zelenika D, Adams E, Humm S, Graca L, Thompson S, Cobbold SP, Waldmann H (2002) Regulatory T cells overexpress a subset of Th2 gene transcripts. J Immunol 168:1069–1079

    PubMed  Google Scholar 

  50. Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S (2002) Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3: 135–142

    PubMed  Google Scholar 

  51. Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057–1061

    PubMed  Google Scholar 

  52. Fontenot JD, Gavin MA, Rudensky AY (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330–336

    PubMed  Google Scholar 

  53. Khattri R, Cox T, Yasayko SA, Ramsdell F (2003) An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4: 337–342

    PubMed  Google Scholar 

  54. von Herrath MG, Harrison LC (2003) Antigen-induced regulatory T cells in autoimmunity. Nat Rev Immunol 3: 223–232

    PubMed  Google Scholar 

  55. Zhang X, Izikson L, Liu L, Weiner HL (2001) Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 167: 4245–4253

    PubMed  Google Scholar 

  56. Thorstenson KM, Khoruts A (2001) Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J Immunol 167: 188–195

    PubMed  Google Scholar 

  57. Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, Shimizu J, Sakaguchi S (1998) Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10: 1969–1980

    PubMed  Google Scholar 

  58. Gavin MA, Clarke SR, Negrou E, Gallegos A, Rudensky A (2002) Homeostasis and energy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol 3: 33–41

    PubMed  Google Scholar 

  59. Bach JF, Francois BJ (2003) Regulatory T cells under scrutiny. Nat Rev Immunol 3:189–198

    PubMed  Google Scholar 

  60. Barthlott T, Kassiotis G, Stockinger B (2003) T cell regulation as a side effect of home-ostasis and competition. J Exp Med 197: 451–460

    PubMed  Google Scholar 

  61. Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3: 253–257

    PubMed  Google Scholar 

  62. Ling EM, Smith TRF, Nguyen XD, Pridgeon CP, Dallman MJ, Arbery J, Carr VA, Robinson DS (2004) Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 363:608–615

    PubMed  Google Scholar 

  63. Bellinghausen I, Klostermann B, Knop J, Saloga J (2003) Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J Allergy Clin Immunol 111: 862–868

    PubMed  Google Scholar 

  64. Tiemessen MM, Van Hoffen E, Knulst AC, Van Der Zee JA, Knol EF, Taams LS (2002) CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow’s milk allergy. J Allergy Clin Immunol 110: 934–936

    PubMed  Google Scholar 

  65. Cavani A, Nasorri F, Ottaviani C, Sebastiani S, De Pita O, Girolomoni G (2003) Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J Immunol 171: 5760–5768

    PubMed  Google Scholar 

  66. Nguyen XD, Robinson DS (2004) Fluticasone propionate increases CD4+CD25+ T cell suppression of allergen-stimulated CD4+CD25 T cells by an IL-10-dependent mechanism. J Allergy Clin Immunol 114: 296–301

    PubMed  Google Scholar 

  67. Pasare C, Medzhitov R (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299: 1033–1036

    PubMed  Google Scholar 

  68. Jordan MS, Boesteanu A, Reed AJ, Petrone AL, Holenbeck AE, Lerman MA, Naji A, Caton AJ (2001) Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2: 301–306

    PubMed  Google Scholar 

  69. Horwitz DA, Zheng SG, Gray JD (2003) The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol 74: 471–478

    PubMed  Google Scholar 

  70. Lloyd CM, Gonzalo JA, Coyle AJ, Gutierrez-Ramos JC (2001) Mouse models of allergic airway disease. Adv Immunol 77: 263–295

    PubMed  Google Scholar 

  71. Suto A, Nakajima H, Kagami SI, Suzuki K, Saito Y, Iwamoto I (2001) Role of CD4(+) CD25(+) regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways. Am J Respir Crit Care Med 164: 680–687

    PubMed  Google Scholar 

  72. Jaffar Z, Sivakuru T, Roberts K (2004) CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype. J Immunol 172: 3842–3849

    PubMed  Google Scholar 

  73. Hadeiba H, Locksley RM (2003) Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170: 5502–5510

    PubMed  Google Scholar 

  74. Thornton AM, Shevach EM (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188:287–296

    PubMed  Google Scholar 

  75. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, Enk AH (2002) Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 196: 255–260

    PubMed  Google Scholar 

  76. Olivares-Villagomez D, Wensky AK, Wang Y, Lafaille JJ (2000) Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. J Immunol 164: 5499–5507

    PubMed  Google Scholar 

  77. Gonzalez A, Andre-Schmutz I, Carnaud C, Mathis D, Benoist C (2001) Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2: 1117–1125

    PubMed  Google Scholar 

  78. Stephens LA, Mason D (2000) CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25 subpopulations. J Immunol 165: 3105–3110

    PubMed  Google Scholar 

  79. Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, Barbosa TC, Cumano A, Bandeira A (2001) CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 166: 3008–3018

    PubMed  Google Scholar 

  80. Sundstedt A, O’Neill EJ, Nicolson KS, Wraith DC (2003) Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J Immunol 170: 1240–1248

    PubMed  Google Scholar 

  81. Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O’Garra A (2002) In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Thl)-and Th2-inducing cytokines. J Exp Med 195:603–616

    PubMed  Google Scholar 

  82. Groux H, O’Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737–742

    PubMed  Google Scholar 

  83. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237–1240

    PubMed  Google Scholar 

  84. Moore KW, de Waal Malefyt R, Coffman RL, O’Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19: 683–765

    PubMed  Google Scholar 

  85. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, Akdis CA (2003) IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eurj Immunol 33: 1205–1214

    Google Scholar 

  86. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S, Deniz G, Valenta R, Fiebig H et al (2004) Immune responses in healthy and allergic Individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 199: 1567–1575

    PubMed  Google Scholar 

  87. EM Ling, M Calderon, D Nguyen, K Powrie, SR Durham, DS Robinson (2004) Allergen immunotherapy increases suppressive activity by CD4+CD25, IL-10 producing T cells, but does not affect suppression by CD4+CD25+ T cells. J Allergy Clin Immunol 113(Suppl) (Abstract 333)

    Google Scholar 

  88. Walker MR, Kasprowicz DJ, Gersuk VH, Benard A, Van Landeghen M, Buckner JH, Ziegler SF (2003) Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25 T cells. J Clin Invest 112: 1437–1443

    PubMed  Google Scholar 

  89. Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+CD25 naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875–1886

    PubMed  Google Scholar 

  90. Ostroukhova M, Seguin-Devaux C, Oriss TB, Dixon-McCarthy B, Yang L, Ameredes BT, Corcoran TE, Ray A (2004) Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest 114: 28–38

    PubMed  Google Scholar 

  91. Levings MK, Sangregorio R, Galbiati F, Squadrone S, de Waal Malefyt R, Roncarolo MG (2001) IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 166: 5530–5539

    PubMed  Google Scholar 

  92. Cottrez F, Hurst SD, Coffman RL, Groux H (2000) T regulatory cells 1 inhibit a Th2-specific response in vivo. J Immunol 165: 4848–4853

    PubMed  Google Scholar 

  93. Akbari O, DeKruyff RH, Umetsu DT (2001) Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2: 725–731

    PubMed  Google Scholar 

  94. Akbari O, Stock P, DeKruyff RH, Umetsu DT (2003) Role of regulatory T cells in allergy and asthma. Curr Opin Immunol 15:627–633

    PubMed  Google Scholar 

  95. Zuany-Amorim C, Sawicka E, Manlius C, Le Moine A, Brunet LR, Kemeny DM, Bowen G, Rook G, Walker C (2002) Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med 8: 625–629

    PubMed  Google Scholar 

  96. British Thoracic Society; Scottish Intercollegiate Guidelines Network (2003) British guideline on the management of asthma. Thorax 58(Suppl 1): il–i94

    Google Scholar 

  97. Bousquet J, Van Cauwenberge P, Khaltaev N; Aria Workshop Group; World Health Organization (2001) Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 108: S147–S334

    PubMed  Google Scholar 

  98. Ellis C, Luger T, Abeck D, Allen R, Graham-Brown RA, De Prost Y, Eichenfield LF, Ferrandiz C, Giannetti A, Hanifin J et al; ICCAD II Faculty (2003) International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. Br J Dermatol 148(Suppl) 63: 3–10

    PubMed  Google Scholar 

  99. Leung DY, Bloom JW (2003) Update on glucocorticoid action and resistance. J Allergy Clin Immunol 111: 3–22

    PubMed  Google Scholar 

  100. Robinson D, Hamid Q, Ying S, Bentley A, Assoufi B, Durham S, Kay AB (1993) Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis 148: 401–406

    PubMed  Google Scholar 

  101. Bentley AM, Hamid Q, Robinson DS, Schotman E, Meng Q, Assoufi B, Kay AB, Durham SR (1996) Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 153: 551–556

    PubMed  Google Scholar 

  102. Hawrylowicz C, Richards D, Loke TK, Corrigan C, Lee T (2002) A defect in corticos-teroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J Allergy Clin Immunol 109: 369–370

    PubMed  Google Scholar 

  103. Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brien F, Noble W, Till SJ, Hamid QA, Nouri-Aria KT (1999) Long-term clinical efficacy of grass-pollen immunotherapy. N Engl Med 341: 468–475

    Google Scholar 

  104. Durham SR, Till SJ (1998) Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol 102: 157–164

    PubMed  Google Scholar 

  105. Jutel M, Pichler WJ, Skrbic D, Urwyler A, Dahinden C, Muller UR (1995) Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 154: 4187–4194

    PubMed  Google Scholar 

  106. Ebner C, Siemann U, Bohle B, Willheim M, Wiedermann U, Schenk S, Klotz F, Ebner H, Kraft D, Scheiner O (1997) Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 27: 1007–1015

    PubMed  Google Scholar 

  107. Akdis CA, Joss A, Akdis M, Blaser K (2001) Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens. Int Arch Allergy Immunol 124: 180–182

    PubMed  Google Scholar 

  108. Pierkes M, Bellinghausen I, Hultsch T, Metz G, Knop J, Saloga J (1999) Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. J Allergy Clin Immunol 103: 326–332

    PubMed  Google Scholar 

  109. Wilson DR, Nouri-Aria KT, Walker SM, Pajno GB, O’Brien F, Jacobson MR, Mackay IS, Durham SR (2001) Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season. J Allergy Clin Immunol 107: 971–976

    PubMed  Google Scholar 

  110. Durham SR, Varney VA, Gaga M, Jacobson MR, Varga EM, Frew AJ, Kay AB (1999) Grass pollen immunotherapy decreases the number of mast cells in the skin. Clin Exp Allergy 29: 1490–1496

    PubMed  Google Scholar 

  111. Varney VA, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, Kay AB, Durham SR (1993) Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 92: 644–651

    PubMed  Google Scholar 

  112. Francis JN, Till SJ, Durham SR (2003) Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol 111: 1255–1261

    PubMed  Google Scholar 

  113. Larche M (2001) Inhibition of human T-cell responses by allergen peptides. Immunology 104: 377–382

    PubMed  Google Scholar 

  114. Oldfield WL, Larche M, Kay AB (2002) Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 360: 47–53

    PubMed  Google Scholar 

  115. Oldfield WL, Kay AB, Larche M (2001) Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol 167: 1734–1739

    PubMed  Google Scholar 

  116. Smith TRF, Alexander C, Kay AB, Larch6 M, Robinson DS (2004) Cat allergen peptide immunotherapy reduces CD4+ T cell responses to cat allergen but does not alter suppression by CD4+CD25+ T cells. Allergy 59: 1097–1101

    PubMed  Google Scholar 

  117. Tighe H, Takabayashi K, Schwartz D, Van Nest G, Tuck S, Eiden JJ, Kagey-Sobotka A, Creticos PS, Lichtenstein LM, Spiegelberg HL, Raz E (2000) Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. J Allergy Clin Immunol 106: 124–134

    PubMed  Google Scholar 

  118. Cohn L, Homer RJ, Niu N, Bottomly K (1999) T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med 190:1309–1318

    PubMed  Google Scholar 

  119. Hansen G, Berry G, DeKruyff RH, Umetsu DT (1999) Allergen-specific Thl cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 103: 175–183

    PubMed  Google Scholar 

  120. Wraith DC (2003) Role of interleukin-10 in the induction and function of natural and antigen-induced regulatory T cells. J Autoimmun 20: 273–275

    PubMed  Google Scholar 

  121. Hoyne GF, Dallman MJ, Champion BR, Lamb JR (2001) Notch signalling in the regulation of peripheral immunity. Immunol Rev 182: 215–227

    PubMed  Google Scholar 

  122. Hoyne GF, Le Roux I, Corsin-Jimenez M, Tan K, Dunne J, Forsyth LM, Dallman MJ, Owen MJ, Ish-Horowicz D, Lamb JR (2000) Serratel-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int Immunol 12:177–185

    PubMed  Google Scholar 

  123. Wong KK, Carpenter MJ, Young LL, Walker SJ, McKenzie G, Rust AJ, Ward G, Pack-wood L, Wahl K, Delriviere L et al (2003) Notch ligation by Deltal inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism. J Clin Invest 112: 1741–1750

    PubMed  Google Scholar 

  124. Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA (2004) Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515–526

    PubMed  Google Scholar 

  125. Yamazaki S, Iyoda T, Tarbell K, Olson K, Velinzon K, Inaba K, Steinman RM (2003) Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 198: 235–247

    PubMed  Google Scholar 

  126. Jiang S, Camara N, Lombardi G, Lechler RI (2003) Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood 102: 2180–2186

    PubMed  Google Scholar 

  127. Bacchetta R, Sartirana C, Levings MK, Bordignon C, Narula S, Roncarolo MG (2002) Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur J Immunol 32: 2237–2245

    PubMed  Google Scholar 

  128. Strachan DP (2000) Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax 55(Suppl 1): S2–S10

    PubMed  Google Scholar 

  129. von Mutius E, Pearce N, Beasley R, Cheng S, von Ehrenstein O, Bjorksten B, Weiland S (2000) International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema. Thorax 55:449–453

    PubMed  Google Scholar 

  130. Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, Bonini S (2000) Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 320: 412–417

    PubMed  Google Scholar 

  131. Shaheen SO, Aaby P, Hall AJ, Barker DJ, Heyes CB, Shiell AW, Goudiaby A (1996) Measles and atopy in Guinea-Bissau. Lancet 347: 1792–1796

    PubMed  Google Scholar 

  132. Holt PG, Macaubas C, Stumbles PA, Sly PD (1999) The role of allergy in the development of asthma. Nature 402: B12–B17

    PubMed  Google Scholar 

  133. van den Biggelaar AH, van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, Yazdanbakhsh M (2000) Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356:1723–1727

    PubMed  Google Scholar 

  134. Black P (2001) Why is the prevalence of allergy and autoimmunity increasing? Trends Immunol 22: 354–355

    Google Scholar 

  135. Wills-Karp M, Santeliz J, Karp CL (2001) The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 1: 69–75

    PubMed  Google Scholar 

  136. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y (1997) The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 159: 1739–1745

    PubMed  Google Scholar 

  137. Kohashi O, Kuwata J, Umehara K, Uemura F, Takahashi T, Ozawa A (1979) Susceptibility to adjuvant-induced arthritis among germfree, specific-pathogen-free, and conventional rats. Infect Immun 26: 791–794

    PubMed  Google Scholar 

  138. Strohmeier GR Fenton MJ (1999) Roles of lipoarabinomannan in the pathogenesis of tuberculosis. Microbes Infect 1: 709–717

    PubMed  Google Scholar 

  139. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J (2003) Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 197: 403–411

    PubMed  Google Scholar 

  140. Ohrui T, Zayasu K, Sato E, Matsui T, Sekizawa K, Sasaki H (2000) Pulmonary tuberculosis and serum IgE. Clin Exp Immunol 122: 13–15

    PubMed  Google Scholar 

  141. Shirakawa T, Enomoto T, Shimazu S, Hopkin JM (1997) The inverse association between tuberculin responses and atopic disorder. Science 275: 77–79

    PubMed  Google Scholar 

  142. Aaby P, Shaheen SO, Heyes CB, Goudiaby A, Hall AJ, Shiell AW, Jensen H, Marchant A (2000) Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy 30: 644–650

    PubMed  Google Scholar 

  143. Matricardi PM, Yazdanbakhsh M (2003) Mycobacteria and atopy, 6 years later: a fascinating, still unfinished, business. Clin Exp Allergy 33: 717–720

    PubMed  Google Scholar 

  144. Arshad SH, Bateman B, Matthews SM (2003) Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study. Thorax 58:489–493

    PubMed  Google Scholar 

  145. Chan-Yeung M, Manfreda J, Dimich-Ward H, Ferguson A, Watson W, Becker A (2000) A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med 154: 657–663

    PubMed  Google Scholar 

  146. Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A (2001) Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet 358:188–193

    PubMed  Google Scholar 

  147. Platts-Mills TA (2004) Allergen avoidance. J Allergy Clin Immunol 113: 388–391

    PubMed  Google Scholar 

  148. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R (2001) Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 357: 752–756

    PubMed  Google Scholar 

  149. Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L, Koivikko A, Koller DY, Niggemann B, Norberg et al (2002) Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 109: 251–256

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Robinson, D.S., Ling, E.M. (2005). Potential for manipulation of regulatory T cells in treatment or prevention of allergic disease. In: Taams, L.S., Wauben, M.H.M., Akbar, A.N. (eds) Regulatory T Cells in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7301-6_10

Download citation

Publish with us

Policies and ethics