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Biotransformations pp 125–144Cite as

Polyamino Acids as Man-Made Catalysts

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((4143,volume 63))

Abstract

Polyamino acids are easy to prepare by nucleophile-initiated polymerisation of amino acid N-carboxyanhydrides. Polymers such as poly-(l)-leucine act as robust catalysts for the epoxidation of a wide range of electron-poor alkenes, such as γ-substituted α,β-unsaturated ketones. The optically active epoxides so formed may be transformed into heterocyclic compounds, polyhydroxylated materials and biologically active compounds such as diltiazem and taxol side chain.

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Liverpool, Liverpool, L69 7DZ, UK

    Joanne V. Allen, Stanley M. Roberts & Natalie M. Williamson

Authors
  1. Joanne V. Allen
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  2. Stanley M. Roberts
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  3. Natalie M. Williamson
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Editor information

Editors and Affiliations

  1. Institute of Organic Chemistry, University of Graz, Heinrichstraße 28, A-8010, Graz, Austria

    Kurt Faber

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© 1998 Springer-Verlag Berlin Heidelberg

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Allen, J.V., Roberts, S.M., Williamson, N.M. (1998). Polyamino Acids as Man-Made Catalysts. In: Faber, K. (eds) Biotransformations. Advances in Biochemical Engineering/Biotechnology, vol 63. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-69791-8_6

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  • DOI: https://doi.org/10.1007/3-540-69791-8_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64496-5

  • Online ISBN: 978-3-540-69791-6

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