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Polynucleotide Arrays for Genetic Sequence Analysis

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Microsystem Technology in Chemistry and Life Science

Part of the book series: Topics in Current Chemistry ((4143,volume 194))

Abstract

We describe a new paradigm for genetic analysis based upon high density arrays of polynucleotide probes. Methods for light-directed polynucleotide array synthesis, as well as array packaging, sample preparation, array hybridization, epifluorescence confocal scanning, and data analysis are described. Applications to discovery, genotyping, expression, and resquencing are presented.

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Author information

Authors and Affiliations

  1. Affymetrix Inc, 3380 Central Expressway, Santa Clara, CA, 95051

    Rolfe C. Anderson, Glenn McGall & Robert J. Lipshutz

Authors
  1. Rolfe C. Anderson
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  2. Glenn McGall
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  3. Robert J. Lipshutz
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Editor information

Editors and Affiliations

  1. Department of Chemistry Imperial College of Science and Technology, Zeneca/Smithkline Beecham Centre for Analytical Sciences, South Kensington London, SW7 2AY

    Andreas Manz  & Holger Becker  & 

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© 1998 Springer Verlag Berlin Heidelberg

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Anderson, R.C., McGall, G., Lipshutz, R.J. (1998). Polynucleotide Arrays for Genetic Sequence Analysis. In: Manz, A., Becker, H. (eds) Microsystem Technology in Chemistry and Life Science. Topics in Current Chemistry, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-69544-3_5

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  • DOI: https://doi.org/10.1007/3-540-69544-3_5

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63424-9

  • Online ISBN: 978-3-540-69544-8

  • eBook Packages: Springer Book Archive

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