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Three-dimensional pattern matching in protein structure analysis

  • Arthur M. Lesk
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 937)

Abstract

Many pattern-matching problems that arise in “one dimension” in the analysis of genomic sequences have three-dimensional analogs in the analysis of protein structures. This report focuses on the identification and matching of common substructures, and treats two problems: the probing of a database of structures with a segment of a protein to identify regions from other proteins with conformations similar to that of the probe, and the determination of the maximal common “rigid subunit” in comparing alternative conformations of a single protein. Approaches based on the representation of structures in terms of lists of coordinates or as a distance matrices are compared.

Keywords

Distance Matrix Distance Matrice Elementary Operation Moment Invariant Common Substructure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Arthur M. Lesk
    • 1
  1. 1.MRC CentreUniversity of Cambridge Clinical SchoolCambridgeUK

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