Skip to main content
SpringerLink
Log in

Optimal range of input resistance in the oscillatory behavior of the pancreatic β-cell

  • Neuroscience
  • Conference paper
  • First Online:
From Natural to Artificial Neural Computation (IWANN 1995)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 930))

Included in the following conference series:

Abstract

The pancreatic β-cell produces the hormone insulin in response to the blood glucose levels. This system is damaged in the diabetes. The central region of the ß-cell electrical response is oscillatory. In this study, we demonstrate that in this region of the response, the membrane resistance of the cells oscillates in phase with the membrane potential. As the cells input resistance reflects the balance of the ionic conductances, we hypothesize that an optimal range of the input resistance determines the capability of the cells to get into oscillations. Under this scope, we propose an electronic circuit able to reproduce the behavior of the biological system. This circuit would be useful to build an artificial insulin pump able to reproduce the physiological pattern.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dean, P.M. and Matthews, E.K. (1968) Nature 219, 389–390.

    PubMed  Google Scholar 

  2. Santos, R.M.; Rosario, L.M.: Nadal, A.; Garcia Sancho, J.; Soria, B. and Valdeolmillos, M. (1991) Pflugers Arch. (Eur. J. Physiol) 418, 417–22.

    Google Scholar 

  3. Wollheim, C.B. and Pralong, W.F. (1990) Biochem. Soc. Trans. 18, 111–4.

    PubMed  Google Scholar 

  4. Rorsman, P., Abrahamsson, H., Gylfe, E. and Hellman, B. (1984) FEBS Lett. 170, 196–220.

    PubMed  Google Scholar 

  5. Soria, B., Martin, F. and Sanchez-Andres, J.V. (1994). In: Frontiers in β-CETTRESEARCH (Flatt, P. and Lenzen, S. eds) Smith-Gordon, London.

    Google Scholar 

  6. Sanchez-Andres, J.V. and Soria, B. (1983) Lect. Notes Comp. Sci. 686, 37–42

    Google Scholar 

  7. Sanchez-Andrés, J.V.; Ripoll, C. and Soria, B. (1988) FEBS Lett. 231, 143–7.

    PubMed  Google Scholar 

  8. Reace, E. Teoría y práctica de los osciladores, Ed. Técnicas REDE, 1989, pp. 151–166.

    Google Scholar 

  9. Kahn, S.E. and Porte Jr. D. In: Diabetes Melittas, Rifkin and Porte eds., 4∘. ed, Elsevier, NY, 1990 pp 436–56.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. de Fisiología. Instituto de Neurociencias, Univ. Alicante, Aptdo. 374, 03080, Alicante, Spain

    E. Andreu, B. Soria, S. Bolea & J. V. Sánchez-Andrés

Authors
  1. E. Andreu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Soria
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Bolea
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. V. Sánchez-Andrés
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

José Mira Francisco Sandoval

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Andreu, E., Soria, B., Bolea, S., Sánchez-Andrés, J.V. (1995). Optimal range of input resistance in the oscillatory behavior of the pancreatic β-cell. In: Mira, J., Sandoval, F. (eds) From Natural to Artificial Neural Computation. IWANN 1995. Lecture Notes in Computer Science, vol 930. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-59497-3_160

Download citation

  • DOI: https://doi.org/10.1007/3-540-59497-3_160

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-59497-0

  • Online ISBN: 978-3-540-49288-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation