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Rhenium complexes labeled with 186,188Re for nuclear medicine

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Technetium and Rhenium Their Chemistry and Its Applications

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 176))

Abstract

Complexes labeled with 186Re and 188Re have been developed for the radiotherapy treatment of diseases because of the desirable nuclear properties of these radioisotopes and because rhenium possesses chemical properties similar to those of technetium, a well-established diagnostic agent. Production of 186Re has been carried out by two methods: one using the 185Re(n,γ)186Re reaction in a nuclear reactor and the other using the 186W(p,n)186Re reaction. From the viewpoint of specific activity, the former is useful when a high flux nuclear reactor is available, but the latter is practicable when a cyclotron is at hand. 188Re has been produced from the double neutron capture reaction of 186W. A generator of 188W/188Re can be successfully prepared when a high flux nuclear reactor is available. The preparation of rhenium complexes (HEDP and MDP) for treating painful bone cancer has been investigated in order to determine the optimum conditions in chemical procedures. Other complexes (DTPA and DMSA) of rhenium have been synthesized for the radiolabeling antibodies. These are reviewed in this paper as well as further studies on antibody labeling using bifunctional ligands.

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Authors and Affiliations

  1. Department of Radioisotopes, Japan Atomic Energy Research Institute, Tokai-mura, Ibaraki-ken, 319-11, Japan

    Kazuyuki Hashimoto

  2. Department of Chemistry, Tohoku University, 980-77, Sendai, Japan

    Kenji Yoshihara

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  1. Kazuyuki Hashimoto
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  2. Kenji Yoshihara
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Kenji Yoshihara Takashi Omori

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© 1996 Springer-Verlag

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Hashimoto, K., Yoshihara, K. (1996). Rhenium complexes labeled with 186,188Re for nuclear medicine. In: Yoshihara, K., Omori, T. (eds) Technetium and Rhenium Their Chemistry and Its Applications. Topics in Current Chemistry, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-59469-8_9

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  • DOI: https://doi.org/10.1007/3-540-59469-8_9

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  • Print ISBN: 978-3-540-59469-7

  • Online ISBN: 978-3-540-49273-3

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