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Technetium and Rhenium Their Chemistry and Its Applications pp 123–148Cite as

Technetium-99m chelates as radiopharmaceuticals

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Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 176))

Abstract

Technetium-99m (99mTc) is currently, and will be in the foreseeable future, the most widely used radionuclide used in virtually all clinical diagnostic Nuclear Medicine laboratories in the world. Several 99mTc radiopharmaceuticals that are routinely used have become important factors in decisions on the diagnosis and treatment of patients with a variety of diseases. More sophisticated biological targeting vectors are being developed by the chemical and biomedical communities. The development of technologies and chelating agents for labeling these vectors with 99mTc, to produce diagnostic radiopharmaceuticals that have optimal in vivo specificities, will be essential for enhancement of the future of Nuclear Medicine in the health care arena worldwide. This chapter is focused primarily on a review of 99mTc complexes used for the formulation of currently approved radiopharmaceuticals, and highlights several chelation systems that are being used in the design of future 99mTc drugs. The chemical and structural properties of different 99mTc complexes and their relationships to their biolocalization and pharmacokinetic properties are described. Emphasis is placed on the importance of developing 99mTc complexes with a high degree of physicochemical flexibility, in order to optimize the pharmacological performance of future 99mTc-labeled drugs.

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Authors and Affiliations

  1. Research Service, HS Truman Memorial VA Hospital and Department of Radiology, 409 Lewis Hall, University of Missouri, 65211, Columbia, MO, USA

    Wynn A. Volkert

  2. Department of Chemistry, 123 Chemistry Building, University of Missouri, 65211, Columbia, MO, USA

    Silvia Jurisson

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  1. Wynn A. Volkert
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Kenji Yoshihara Takashi Omori

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Volkert, W.A., Jurisson, S. (1996). Technetium-99m chelates as radiopharmaceuticals. In: Yoshihara, K., Omori, T. (eds) Technetium and Rhenium Their Chemistry and Its Applications. Topics in Current Chemistry, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-59469-8_5

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