Advertisement

Polymer-coated adsorbents for the separation of biopolymers and particles

  • A. E. Ivanov
  • V. V. Saburov
  • V. P. Zubov
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 104)

Abstract

Polymer-coated mineral supports are materials attracting increasing interest in the field of bioseparation. Adsorbents of this type often combine the rigidity of silica, the biocompatibility of organic gels and/or the chemical stability of bulky polymers. The review collects the methods of preparation, structures of the stationary phases as well as probable mechanisms of their interaction with biomacromolecules. It was our aim to analyze the interrelation between the structural and chromatographic characteristics of composite adsorbents. Up to now specific properties of the surface-covering polymers (such as an excluded volume effect, segment dynamics, etc.) have hardly come under the scruting of chromatography researchers. Recently, a number of applications have confirmed that the value of the polymer structure should be taken into accounting. In this paper both hydrophilic diffuse polymer layers and condensed thin hydrophobic films are considered as interfaces of the adsorbing media. The most promising types of bioseparation procedures are given for each type of adsorbent.

Keywords

Size Exclusion Chromatography Size Exclusion Chromatography Porous Silica Graft Polymerization Vinyl Monomer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

7 References

  1. 1.
    Ivanov AE, Saburov VV, Zubov VP (1989) Zh Vses Khim Ob-va im DI Mendeleeva (in Russian) 34: 368Google Scholar
  2. 2.
    Lee JH, Kopecek J, Andrade JD (1989) J Biomed Mat Res 23: 351Google Scholar
  3. 3.
    Matsunaga T, Ikada Y (1981) J Coll Interface Sci 84(1): 8Google Scholar
  4. 4.
    Ikada Y, Suzuki M, Tamada Y (1984) In: Shalaby SW (ed) Polymers as Biomaterials. Plenum, New York, p 135Google Scholar
  5. 5.
    Absolom DR, Zingg W, Newmann AW (1987) In: Brash JL (ed) Proteins at interfaces. ACS Symposium Series 343, American Chemical Society, Washington, p 401Google Scholar
  6. 6.
    Nagaoka S, Mori Y, Takiuchi H, Yokota K, Tanzawa H, Nishiumi S (1984) In: Shalaby SW (ed) Polymers as biomaterials. Plenum, New York, p 361Google Scholar
  7. 7.
    Lee JH, Kopeckova P, Kopecek J, Andrade JD (1990) Biomaterials 11: 455Google Scholar
  8. 8.
    Klein J, Luckham P (1982) Nature 300: 429Google Scholar
  9. 9.
    Hesselink FTh (1969) J Phys Chem 73: 3488Google Scholar
  10. 10.
    Scheutjens JMHM, Fleer GJ (1979) J Phys Chem 83: 1619Google Scholar
  11. 11.
    de Gennes PG (1981) Macromolecules 14: 1637Google Scholar
  12. 12.
    Scheutjens JMNM, Fleer GJ (1985) Macromolecules 18: 1882Google Scholar
  13. 13.
    Robb ID, Smith R (1974) Eur Polym J (1974) 10: 1005Google Scholar
  14. 14.
    Robb ID, Smith R (1977) Polymer 18: 500Google Scholar
  15. 15.
    Kawaguchi M, Hagakawa M, Takahashi A (1980) Polym J 12: 265Google Scholar
  16. 16.
    Furusawa K, Yamamoto K (1983) Bull Chem Soc Jpn 56: 1958Google Scholar
  17. 17.
    Sakai H, Imamura Y (1987) Bull Chem Soc Jpn 60: 1261Google Scholar
  18. 18.
    Fleer GJ, Lyklema J (1987) Biol Chem Hoppe-Seyler 368: 741Google Scholar
  19. 19.
    Barford W, Ball RC, Nex CCM (1986) J Chem Soc, Faradey Trans 1, 82: 3233Google Scholar
  20. 20.
    Barford W, Ball RC (1987) J Chem Soc, Faradey Trans 1, 83: 2515Google Scholar
  21. 21.
    Luckham PF, Klein J (1984) J Chem Soc, Faradey Trans 1, 80: 865Google Scholar
  22. 22.
    Ball RC, Blunt M, Barford W (1989) J Phys A: Math Gen 22: 2587Google Scholar
  23. 23.
    Douglas JF (1989) Macromolecules 22: 3707Google Scholar
  24. 24.
    Hommel H, Legrand AP, Tougne P, Balard H, Papirer E (1984) Macromolecules 17: 1578Google Scholar
  25. 25.
    Cohen Stuart MA, Waajen FHWH, Cosgrove T, Vincent B, Crowley TL (1984) Macromolecules 17: 1825Google Scholar
  26. 26.
    Peffercorn E, Haouam A, Varoqui R (1989) Macromolecules 22: 2677Google Scholar
  27. 27.
    Cosgrove T (1982) Macromolecules 15: 1290Google Scholar
  28. 28.
    Hiatt CW, Shelokov A, Rosental EJ, Galimore JM (1971) J Chromatogr 56: 362Google Scholar
  29. 29.
    Darling T, Albert J, Russel P, Albert DM, Reid TW (1977) J Chromatogr 131: 383Google Scholar
  30. 30.
    Letot L, Lesec J, Quivoron C (1981) J Liq Chromatogr 4: 1311Google Scholar
  31. 31.
    Dulout C, Peyroset A, Panaris R, Hannoun C, Vincent J (1980) US Patent No 4199450Google Scholar
  32. 32.
    Kopjov VP, Zhigis LS, Reshetov PD, Baburina TM, Brylina VI, Panteleev YuV, Surin VN (1989) Vopr Virusol (in Russian) 6: 760Google Scholar
  33. 33.
    Belousova RV, Lobova TP, Kopjov VP, Ishkildin IB, Zhigis LS, Reshetov PD (1990) Veterenaria (in Russian) 11: 53Google Scholar
  34. 34.
    Tardy M, Tayot JL, Roumyantseff M, Plan R (1978) In: Epton R (ed) Chromatography of synthetic and biological polymers, vol 2, Ellis Horwood, Chichester, p 231Google Scholar
  35. 35.
    Santarelli X, Muller D, Jozefonvicz J (1988) J Chromatogr 443: 55Google Scholar
  36. 36.
    Zhou FL, Muller D, Santarelli X, Jozefonvicz J (1989) J Chromatogr 476: 195Google Scholar
  37. 37.
    Alpert A, Regnier FE (1979) J Chromatogr 185: 375Google Scholar
  38. 38.
    Flashner M, Ramsden H, Crane LJ (1983) Anal. Biochem. 135: 340Google Scholar
  39. 39.
    Lawson TG, Regnier FE, Weith HL (1983) Anal Biochem 133: 85Google Scholar
  40. 40.
    Jastrebov SI, Popov SG (1986) Bioorgan Khim (in Russian) 12: 661Google Scholar
  41. 41.
    Wilchek M (1973) FEBS Lett 33: 70Google Scholar
  42. 42.
    Meiller F, Bonnebat C, Deleuil M (1976) US Patent No 3984349Google Scholar
  43. 43.
    Kurganov A, Kuzmenko O, Davankov VA, Eray B, Unger KK, Trudinger U (1990) J Chromatogr 506: 391Google Scholar
  44. 44.
    Davankov VA, Kurganov AA, Unger KK (1990) J Chromatogr 500: 519Google Scholar
  45. 45.
    Gupta S, Pfannkoch E, Regnier FE (1983) Anal Biochem 128: 196Google Scholar
  46. 46.
    Fausnaugh JL, Pfannkoch F, Gupta S, Regnier FE (1984) Anal Biochem 137: 464Google Scholar
  47. 47.
    Alpert A (1983) J Chromatogr 266: 23Google Scholar
  48. 48.
    Alpert A (1986) J Chromatogr 359: 85Google Scholar
  49. 49.
    Nomura A, Yamada J, Tsunoda KI (1987) Anal Sci 3: 209Google Scholar
  50. 49.
    Gupta S, Pfannkoch E, Regnier FE (1983) Anal Biochem 128: 196Google Scholar
  51. 50.
    Ivanov AE, Zhigis LS, Chekhovskykh EYu, Reshetov PD, Zubov VP (1985) Bioorgan Khim (in Russian) 11: 1527Google Scholar
  52. 51.
    Ivanov AE, Zhigis LS, Turchinsky MF, Kopjov VP, Reshetov PD, Zubov VP, Kastrikina LN, Lonskaya NI (1987) Mol Genet Mikrobiol Virusol (in Russian) 11: 39Google Scholar
  53. 52.
    Nazhmidinov Sh, Turaev AS, Usmanov KhU, Bazarbayev A (1973) J Polym Sci 42: 1591Google Scholar
  54. 53.
    Ivanov AE, Zhigis LS, Reshetov PD, Zubov VP (1987) Proceedings of 3rd All-Union Conference on Water-Soluble Polymers (in Russian) 27–31 May 1987, Irkutsk, USSR, p 196Google Scholar
  55. 54.
    Ivanov AE, Turkin SI, Zubov VP (1985) USSR Patent No. 1,151,295Google Scholar
  56. 55.
    Ivanov AE, Belov SV, Sklovsky MD, Zubov VP (1991) Vysokomol Soed (in Russian) 33B: 289Google Scholar
  57. 56.
    Ivanov AE, Verkhovskaya LV, Khilko SN, Zubov VP (1990) Bioorgan Khim (in Russian) 16: 1028Google Scholar
  58. 57.
    Ivanov AE, Wulfson AN, Jakimov SA, Zubov VP, Arutjunyan AM (1990) Proceedings of 5th All-Union Symposium on Molecular Liquid Chromatography (in Russian). 20–22 November 1990, Riga, USSR, p 172Google Scholar
  59. 58.
    Miller NT, Feisbush B, Karger BL (1984) J Chromatogr 316: 513Google Scholar
  60. 59.
    Chang JE, El Rassi Z, Horvath Cs (1985) J Chromatogr 319: 396Google Scholar
  61. 60.
    El Rassi Z, Horvath Cs (1986) J Liq Chromatogr 9: 3245Google Scholar
  62. 61.
    Miller NT, Feisbush B, Corina K, Powers-Lee S, Karger BL (1985) Anal Biochem 148: 510Google Scholar
  63. 62.
    Papirer E, Nguyen Van Tao (1972) J Polym Sci 10B: 167Google Scholar
  64. 63.
    Iler RC (1979) The chemistry of Silica, Wiley, NYGoogle Scholar
  65. 64.
    Papirer E, Nguyen Van Tao (1973) Angew Makromol Chem 28: 31Google Scholar
  66. 65.
    Wheals BB (1975) J Chromatogr 107: 402Google Scholar
  67. 66.
    Bryk MT (1981) Polymerization on the solid surface of the inorganic substances, Naukova Dumka, Kiev, USSRGoogle Scholar
  68. 67.
    Ivanchev SS (1985) Radical polymerization (in Russian), Leningrad, KhimiyaGoogle Scholar
  69. 68.
    Bruk MA, Pavlov SA (1990) Polymerization on solid surfaces (in Russian), Khimiya, Moscow, USSRGoogle Scholar
  70. 69.
    Babkin IYu, Tzetlin BL (1973) Zh Vses Khim Ob-va im DI Mendeleeva (in Russian) 18: 263Google Scholar
  71. 70.
    Bruk MA (1987) Uspekhi Khimii (in Russian) 56: 148Google Scholar
  72. 71.
    Pavlov SA, Bruk MA, Isaeva GG, Abkin AD (1981) Dokl Akad Nauk USSR (in Russian) 259: 159Google Scholar
  73. 72.
    Kosaka Y, Uemura M, Hashimoto T, Fukano K (1977) US Patent No. 4045353Google Scholar
  74. 73.
    Dinh-Ngoc B, Rabe JG, Schnabel W (1975) Angew Makromol Chem 46: 23Google Scholar
  75. 74.
    Olenin AV, Khristyuk AL, Golubev VB, Zubov VP, Kabanov VA (1983) Vysokomol Soed (in Russian) 25A: 423Google Scholar
  76. 75.
    Kusama Y, Udagawa A, Takehisa M (1979) J Polym Sci Polym Chem Ed 17: 393Google Scholar
  77. 76.
    Bruk MA, Abkin AD, Demidovich VV, Eroshina LV, Urman YaG, Slonim MYa, Ledeneva NV (1975) Vysokomol Soed (in Russian) 17A: 3Google Scholar
  78. 77.
    Saburov VV, Muydinov MR, Guryanov SA, Kataev AD, Turkin SI, Zubov VP (1990) Proceedings of 5th All-Union Symposium on Molecular Liquid Chromatography (in Russian). 20–22 November 1990, Riga, USSR, p 207Google Scholar
  79. 78.
    Mueller W (1988) 8th Intern Symposium on HPLC of Proteins, Peptides and Polynucleotides, Copenhagen, Oct 31–Nov 2, 1988Google Scholar
  80. 79.
    Tutaeva NL, Komarov VS (1975) Dokl Akad Nauk Byelorussian SSR (in Russian) 19: 803Google Scholar
  81. 80.
    Tutaeva NL, Komarov VS, Belyakova MD (1981) Dokl Akad Nauk Byelorussian SSR (in Russian) 25: 45Google Scholar
  82. 81.
    Ivanchev SS, Dmitrenko AV, Shadrina NE, Volkov AM, Ulinskaya NN (1987) Dokl Akad Nauk USSR (in Russian) 297: 402Google Scholar
  83. 82.
    Kalal J, Tlustakova M (1979) Acta Polymerica 30: 40Google Scholar
  84. 83.
    Bleha M, Votavova E, Tlustakova M, Kalal J (1982) Angew Makromol Chem 107: 25Google Scholar
  85. 84.
    Schneider B, Doskocilova D, Stokr J, Tlustakova M, Kalal J (1979) Acta Polymerica 30: 283Google Scholar
  86. 85.
    Gobel G, Starnic J (1978) Angew Makromol Chem 71: 167Google Scholar
  87. 86.
    Ivanchev SS, Golgman AJa, Dmitrenko AV, Krupnik AM, Perepechko II (1985) Dokl Akad Nauk USSR (in Russian) 283: 1225Google Scholar
  88. 87.
    Barabas ES, Grosser F (1976) US Patent No. 3941718Google Scholar
  89. 88.
    Ivanchev SS, Dmitrenko AV (1985) Plast und Kaut (in Russian) 32: 41Google Scholar
  90. 89.
    Korshak VV, Zubakova LB, Kachurina NV, Balashova OB (1979) Vysokomol Soed (in Russian) 21A: 1132Google Scholar
  91. 90.
    Chaimberg M, Parnas R, Cohen Y (1989) J Appl Polym Sci 37: 2921Google Scholar
  92. 91.
    Hayakawa K, Kawase K, Yamakita H (1977) J Appl Polym Sci 21: 2921Google Scholar
  93. 92.
    Mchedlishvili BV, Smirnov AV, Mertvuhina ON, Molodkina LM, Makarova SB, Kolikov VM, Venzel BI, Petuhov VV, Molodkin VM (1984) Colloid Z (in Russian) 46: 132Google Scholar
  94. 93.
    Abuelafiya R, Pesek J (1989) J Liq Chrom 12: 1571Google Scholar
  95. 94.
    Rosevear A, Mattock P (1981) UK Patent No. 1602432Google Scholar
  96. 95.
    Chang SH, Regnier FE (1977) US Patent No. 4029583Google Scholar
  97. 96.
    Gorkovenko AA, Berman EL, Zubov VP, Ponomarenko VA (1987) Izvestiya Akad Nauk USSR, Seriya Khimich (in Russian) 9: 2091Google Scholar
  98. 97.
    Schutijser JA (1983) US Patent No. 4415631Google Scholar
  99. 98.
    Rogers ME, Adlard MW, Saunders G, Holf G (1985) J Chromatogr 326: 163Google Scholar
  100. 99.
    Fukano K, Komiya K, Sasaki H, Hashimoto T (1978) J Chromatogr 166: 47Google Scholar
  101. 100.
    Wehr CT, Abbott SR (1979) J Chromatogr 185: 453Google Scholar
  102. 101.
    Kato Y, Komiya K, Hashimoto T (1982) J Chromatogr 246: 13Google Scholar
  103. 102.
    Mino G, Kaizerman S (1958) J Polym Sci 31: 242Google Scholar
  104. 103.
    Mueller W (1986) Kontakte (Darmstadt) 3: 3Google Scholar
  105. 104.
    Mueller W (1987) Kontakte (Darmstadt) 1: 45Google Scholar
  106. 105.
    Albertsson PA (1971) Partition of cell particles and macromolecules, Almquist Z Wichsell, Stockholm, SwedenGoogle Scholar
  107. 106.
    Kopacievicz W, Rounds MA, Fausnaugh J, Regnier FE (1983) J Chromatogr 266: 3Google Scholar
  108. 107.
    Mueller W (1990) J Chromatogr 510: 133Google Scholar
  109. 108.
    Tweeten KA, Tweeten TN (1986) J Chromatogr 359: 111Google Scholar
  110. 109.
    Billiet HAH, Schoenmakers PJ, De Galan L (1981) J Chromatogr 218: 443Google Scholar
  111. 110.
    Sadek PC, Carr PW (1984) J Chromatogr 288: 25Google Scholar
  112. 111.
    Xindu G, Carr PW (1983) J Chromatogr 269: 96Google Scholar
  113. 112.
    Hjerten S (1978) J Chromatogr 159: 47Google Scholar
  114. 113.
    Hjerten S, Hellman U (1980) J Chromatogr 202: 391Google Scholar
  115. 114.
    Williams RC, Vasta-Russell JF, Golebowski K (1986) J Chromatogr 371: 63Google Scholar
  116. 115.
    Saburov VV, Turkin SI, Muydinov MR, Ivanov SV, Zubov VP (1986) Proceedings of Chromatography in biology and medicine. International symposium. Moscow, p 200Google Scholar
  117. 116.
    Saburov VV, Vener TI, Gilyarevsky SD, Ivanov SV (1988) 14th International Congress of Biochemistry, Prague, Vol 1, p 235Google Scholar
  118. 117.
    Jervis L (1978) In: Epton R (ed) Chromatography of synthetic and biological polymers, vol 2, Ellis Horwood, Chichester, p 231Google Scholar
  119. 118.
    Hipwell MC, Harvey MJ, Dean PDG (1974) FEBS Lett. 42: 355Google Scholar
  120. 119.
    Tayot JL, Tardy M (1979) French Patent No. 2403098Google Scholar
  121. 120.
    Parikh I, Cuatrecasas P (1974) Methods in Enzymology 34: 610Google Scholar
  122. 121.
    Muller-Schulte D (1990) J Chromatogr 510: 115Google Scholar
  123. 122.
    Tay SW, Merril EW, Salzman EW, Lindon J (1989) Biomaterials 10: 11Google Scholar
  124. 123.
    Bootsma JPC, Wolsink HW, Challa G, Muller F (1984) Polymer 25: 1327Google Scholar
  125. 124.
    Bovin NV, Zemlyanukhina TV, Chagiashvili TsN, Khorlin AJa (1988) Khim Prir Soed (in Russian) 6: 777Google Scholar
  126. 125.
    Chagiashvili TsN, Zotikov EA, Bovin NV, Korchagina EYu (1989) Hematol Transfusiol (in Russian) 8: 56Google Scholar
  127. 126.
    Kozlov LV, Shojbonov BB, Ivanov AE, Zubov VP, Antonov VK (1989) Biokhimia (in Russian) 54: 1745Google Scholar
  128. 127.
    Ivanov AE, Kozlov LV, Shojbonov BB, Zubov VP, Antonov VK (1991) Biomed Chromatogr 5: 90Google Scholar
  129. 128.
    Denisova OV, Myagkova MA, Balabanova RM, Solovyev SK, Ivanov AE, Alyoshkin VA (1988) Lab Delo (in Russian) 9: 48Google Scholar
  130. 129.
    Vaneeva LI, Jankina NF, Ivanov AE, Razgulyaeva OA, Zubov VP (1989) Zh Mikrobiol Epidemiol Immunobiol (in Russian) 5: 50Google Scholar
  131. 130.
    Ivanov AE, Grin MA, Zhiltsov VV, Kizjun SM, Afanasenko GA, Zubov VP (1990) Prikl Biokhim i Mikrobiol (in Russian) 26: 840Google Scholar
  132. 131.
    Ivanov AE, Turková J, Čapka M, Zubov VP (1990) Biocatalysis 3: 235Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. E. Ivanov
    • 1
  • V. V. Saburov
    • 1
  • V. P. Zubov
    • 1
  1. 1.Shemyakin Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

Personalised recommendations