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Polyelectrolytes Hydrogels Chromatographic Materials pp 135–175Cite as

Polymer-coated adsorbents for the separation of biopolymers and particles

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 104))

Abstract

Polymer-coated mineral supports are materials attracting increasing interest in the field of bioseparation. Adsorbents of this type often combine the rigidity of silica, the biocompatibility of organic gels and/or the chemical stability of bulky polymers. The review collects the methods of preparation, structures of the stationary phases as well as probable mechanisms of their interaction with biomacromolecules. It was our aim to analyze the interrelation between the structural and chromatographic characteristics of composite adsorbents. Up to now specific properties of the surface-covering polymers (such as an excluded volume effect, segment dynamics, etc.) have hardly come under the scruting of chromatography researchers. Recently, a number of applications have confirmed that the value of the polymer structure should be taken into accounting. In this paper both hydrophilic diffuse polymer layers and condensed thin hydrophobic films are considered as interfaces of the adsorbing media. The most promising types of bioseparation procedures are given for each type of adsorbent.

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Authors and Affiliations

  1. Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, Russia

    A. E. Ivanov, V. V. Saburov & V. P. Zubov

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  1. A. E. Ivanov
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  2. V. V. Saburov
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  3. V. P. Zubov
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Ivanov, A.E., Saburov, V.V., Zubov, V.P. (1992). Polymer-coated adsorbents for the separation of biopolymers and particles. In: Polyelectrolytes Hydrogels Chromatographic Materials. Advances in Polymer Science, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-55109-3_4

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  • DOI: https://doi.org/10.1007/3-540-55109-3_4

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