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Crosslinked polyelectrolytes in biology

  • Georgy V. Samsonov
  • Nina P. Kuznetsova
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 104)

Abstract

This review deals with the structure and properties of highly permeable crosslinked polyelectrolytes synthesized mainly by using acrylic acids and various polyvinyl crosslinking agents. Special attention was directed to macro- and heteroreticular polyelectrolytes with high inhomogeneity. The mobility of parts of polymer chains located between chemical and physical junctions was demonstrated. The biological aspect of these systems was analyzed on the basis of thermodynamic selectivity and kinetic relationships in the interaction between crosslinked polyelectrolytes and biologically active molecules and ions.

Special emphasis was put on the properties and application of the microdisperse forms of crosslinked polyelectrolytes. The possibilities of using highly permeable crosslinked polyelectrolytes for immobilization of proteins (and enzymes) and new approaches to the use of crosslinked polyelectrolytes biosorbents in preparative chromatography were also considered.

Keywords

Crosslinking Agent Conformational Transition Ionogenic Group Preparative Chromatography Biologically Active Substance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of abreviations

CP

crosslinked polyelectrolyte

AA

acrylic acid

MA

methacrylic acid

PAA

polyacrylic acid

PMA

polymethacrylic acid

DVB

divinylbenzene

AA-DVB

acrylic acid-divinylbenzene copolymer

St-DVB

styrene-divinylbenzene copolymer

EDMA

N,N′-ethylene dimethacrylamide

HHTT

hexahydro-1,3,5-triacryloyltriazine

DMEG

ethylene glycol dimethacrylate

Ac A

acetic acid

gr.

grain

AA-EDMA

acrylic acid-ethylene dimethacrylamide copolymer

MA-EDMA

methacrylic acid-ethylene dimethacrylamide copolymer

MA-DMEG

methacrylic acid-ethylene glycol dimethacrylate copolymer

MA-HHTT

(Biocarb-T) — methacrylic acid-hexahydro-1,3,5-triacryloyltriazine copolymer

BAS

biologically active substance

Hb

haemoglobin

SA

serum albumin

Ls

lysozyme

P

protein

Im Hb

immobilized Hb in microdispersion of CP

KU-1

sulfophenol condensed with formaldehyde

KU-2

sulfonated copolymer of styrene and divinylbenzene

KU-23

macroporous sulfonated copolymer of styrene and divinylbenzene

SDV-T

telagenated product of sulfonated copolymer of styrene and divinylbenzene

KRC

sulfonated copolymers of styrene and p-divinylbenzene (4,5 mol% of crosslinking agent)

SBS

sulfonated copolymer of styrene and butadiene

Dowex-50

sulfonated copolymer of styrene and divinylbenzene

SDMDMA

sulfonated copolymer of methacrylamide and N,N′-decamethylene dimethacrylamide

SHMDMA

sulfonated copolymer of methacrylamide and N,N′-hexamethylene dimethacrylamide

SEDMA

sulfonated copolymer of methacrylamide and N,N′-ethylene dimetacrylamide

CS-KU-2 (KU-23)

KU-2 (KU-23) immobilized in cellulose grains

KB-2

copolymer of acrylic acid and divinylbenzene

KB-4

copolymer of methacrylic acid and divinylbenzene

KMDM-6

copolymer of methacrylic acid and N,N′-hexamethylene dimethacrylamide

KFA

condensation product of phenoxyacetic acid with formaldehyde

AV-16

condensation product of pyridine and polyethylene polyamines with epichlorohydrin

AV-17

aminated chloromethylated copolymer of styrene and divinylbenzene

FAV-16 FAV-17

microdisperse grains of AV-16 or AV-17

CS-AV-17

AV-17 immobilized in cellulose grains

ARA

aminated chloromethylated copolymer of styrene and p-divinylbenzene

FAF

phenoxyethyltrimethylammonium salt condensed with formaldehyde

ASB-3

aminated chloromethylated copolymer of styrene and butadiene

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Georgy V. Samsonov
    • 1
  • Nina P. Kuznetsova
    • 1
  1. 1.Institute of Macromolecular CompoundsAcademy of SciencesUSSR

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