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Intracellular Transport and Kinesin Superfamily Proteins: Structure, Function and Dynamics

  • N. Hirokawa
  • R. Takemura
Part of the Lecture Notes in Physics book series (LNP, volume 711)

Abstract

Using various molecular cell biological and molecular genetic approaches, we identified kinesin superfamily proteins (KIFs) and characterized their significant functions in intracellular transport, which is fundamental for cellular morphogenesis, functioning, and survival. We showed that KIFs not only transport various membranous organelles, proteins complexes and mRNAs fundamental for cellular functions but also play significant roles in higher brain functions such as memory and learning, determination of important developmental processes such as left-right asymmetry formation and brain wiring. We also elucidated that KIFs recognize and bind to their specific cargoes using scaffolding or adaptor protein complexes. Concerning the mechanism of motility, we discovered the simplest unique monomeric motor KIF1A and determined by molecular biophysics, cryoelectron microscopy and X-ray crystallography that KIF1A can move on a microtubule processively as a monomer by biased Brownian motion and by hydolyzing ATP.

Keywords

Brownian Movement Intracellular Transport Motor Domain Situs Inversus NR2B Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

Authors and Affiliations

  • N. Hirokawa
    • 1
  • R. Takemura
    • 2
  1. 1.Department of Cell Biology and AnatomyGraduate School of Medicine, University of TokyoTokyoJapan
  2. 2.Okinaka Memorial Institute for Medical ResearchTokyoJapan

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