Abstract
Systems consisting of cyclosporin A (CsA), a cyclic peptide which is an effective immunosuppressive agent for transplanted organs, and dipalmitoylphosphatidylcholine (DPPC), a liposomal phospholipid, obey the molecular area additivity rule when spread as mixed monolayers at the air/water interface. This behaviour is ascribed to the immiscibility of the system components, which orientate themselves differently on the surface. The insertion of a pyrene residue in the DPPC molecule, whether in the non-polar chain to obtain 1-hexa-decanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphocholine (H-361) or in the polar group to form N-(1-pyrenesulfonyl)-l,2-phospho-ethanolamine triethylammonium (P-58), has no effect on the surface behaviour of the cyclosporin-phos-pholipid system, which remains additive in its molecular areas and hence immiscible at the interface.
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Sández, I., Suárez, A., Gil González, A., Arístegui, I., Miñones Trillo, J. (1999). Pressure-area isotherms: the behaviour of cyclosporin/pyrene-labelled phospholipid systems. In: Težak, D., Martinis, M. (eds) Trends in Colloid and Interface Science XIII. Progress in Colloid and Polymer Science, vol 112. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48953-3_8
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DOI: https://doi.org/10.1007/3-540-48953-3_8
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