Abstract
HEPASCORE has been developed to optimize the application of objective criteria for qualitative and quantitative assessment of liver function. Early recognition of abnormal liver states is performed according to a sequential approach, based at first on clinical rules using data from history and physical examination, then confirming or denying the hypothesis by means of selected laboratory tests. Once an abnormal condition is defined, clinical severity can be evaluated using suitable scores. In addition, selected sets of biochemical tests can be used to score one or more functional aspects. HEPASCORE has been successfully applied to exclude liver abnormalities in subjects at risk, to follow-up liver patients, to predict the natural outcomes of severe liver diseases, to foresee the adverse effects of drugs undergoing firstpass liver extraction and the side effects of invasive procedures.
Keywords
- Primary Biliary Cirrhosis
- Functional Evaluation
- Elimination Capacity
- Primary Biliary Cirrhosis Patient
- Clinical Rule
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Belforte, G., Bona, B., Cravetto, C., et al.: Selection and assessment of laboratory tests for the evaluation of liver functional impairment. Methods Inf. Med. 24 (1985) 39–45.
Tygstrup, N.: Determination of the hepatic elimination capacity of galactose by single injection. Scand. J. Clin. Lab. Invest. 18 Suppl 92 (1966) 118–125.
Molino, G., Cramp, D.G.: The diagnosis and management of liver diseases: a systems approach. In: Cramp, D.G., Carson, E.R. (eds.): Measurements in medicine: liver function. Chapman and Hall, London (1989) 224–257.
Lesmo, L., Marzuoli, M., Molino, G., Torasso, P.: An expert system for the evaluation of liver functional assessment. J. Med. Syst. 8 (1984) 73–85.
Christensen E.: Prognostic models in chronic liver diseases: validity, usefulness and future role. J. Hepatol. 26(6) (1997) 1414–1424.
Molino, G., Battista, S., Bar, F. et al.: Determination of functional portal-sytemic shunting in patients submitted to hepatic angiography. Liver 16 (1996) 347–352.
Molino, G., Avagnina, P., Belforte, G., Bircher, J.: Assessment of the hepatic circulation in humans: New concepts based on evidence derived from a D-sorbitol clearance method. J. Lab. Clin. Med. 131 (1998) 393–405.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Torchio, M. et al. (1999). A Decision-Support System for the Identification, Staging, and Functional Evaluation of Liver Diseases (HEPASCORE). In: Horn, W., Shahar, Y., Lindberg, G., Andreassen, S., Wyatt, J. (eds) Artificial Intelligence in Medicine. AIMDM 1999. Lecture Notes in Computer Science(), vol 1620. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48720-4_17
Download citation
DOI: https://doi.org/10.1007/3-540-48720-4_17
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-66162-7
Online ISBN: 978-3-540-48720-3
eBook Packages: Springer Book Archive