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Effects of Hydrodynamic and Interfacial Forces on Plant Cell Suspension Systems

  • Patricia M. Kieran
  • Dermot M. Malone
  • P. Frank MacLoughlin
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 67)

Abstract

Plant cells are perceived to be sensitive to the hydrodynamic environment in conventional bioreactors. Heightened sensitivity, relative to most bacterial cultures, is frequently attributed to larger plant cell sizes, extensive vacuolization and aggregation patterns. Early studies of shear sensitivity focused on cell lysis and/or loss of viability. More recently, an extensive ar- ray of sub-lethal responses has been identified. A fuller understanding of these sub-lytic ef- fects may assist in the optimization of large-scale cultivation conditions. This paper reviews recent work on the hydrodynamic shear sensitivity of plant cell systems, under cultivation conditions and in purpose-built shearing devices. The relevance of different approaches to the characterization of the intensity of a given hydrodynamic environment is discussed. Indicators of cell response to hydrodynamic stress are evaluated. The potential significance of cellular defense mechanisms, observed in response to mechanical stimulants, is identified.

Keywords

Plant cell suspensions Hydrodynamic shear Energy dissipation Aeration Oxidative burst 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Patricia M. Kieran
    • 1
  • Dermot M. Malone
    • 1
  • P. Frank MacLoughlin
    • 1
  1. 1.Department of Chemical EngineeringUniversity College DublinBelfield, Dublin 4Ireland

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