Preparation strategies for phosphate-based mineral biomaterials

  • S. F. WilligerothEmail author
  • K. Beneke
  • M. Hannig
  • R. Zimehl
Conference paper
Part of the Progress in Colloid and Polymer Science book series (PROGCOLLOID, volume 121)


Minerals with different particle size and morphology were prepared, and the effects of different preparation methods were analyzed. The minerals, fluoroapatites, were synthesized from CaCl2, Na2HPO4 and KF by precipitation in aqueous solution, precipitation in microemulsions and by a biomimetic synthesis in a gelatine matrix. Several characterization methods were used. The effects of varying the synthesis conditions on the size and the morphology of the powder were analyzed with scanning and transmission electron microscopy. The crystallinity and phase purity were determined by X-ray diffraction and Fourier transform IR spectroscopy. The particle sizes were measured by transmission electron microscopy and dynamic light scattering. Precipitation from aqueous solution yielded particles with rodshaped and amorphous morphology, whereas precipitation from a microemulsion resulted in rod-shaped crystals and after tempering in amorphous shapes. Spherical particles were obtained by biomimetical synthesis. The smallest size of the primary particles was about 15 nm and the largest was about 200 μm.

Key words

Phosphates Fluoroapatite Particle size Morphology 


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  1. 1.
    De Groot K (1984) Bioceramics of calcium phosphate. CRC, Boca RatonGoogle Scholar
  2. 2.
    De Groot K (1980) Biomaterials 1:47CrossRefGoogle Scholar
  3. 3.
    Lin FH (1994) Biomaterials 15:1087CrossRefGoogle Scholar
  4. 4.
    JCPDS files. Swarthmore, Pennsylvania, PaGoogle Scholar
  5. 5.
    Elliot JC (1994) Structure and chemistry of the apatites and other calcium orthophosphates. Elsevier, AmsterdamGoogle Scholar
  6. 6.
    Klee WE (1970) Z Kristallogr 131:95CrossRefGoogle Scholar
  7. 7.
    Elliot JC (1964) PhD thesis. University of LondonGoogle Scholar
  8. 8.
    Elliot JC (1964) In: Fearnhead RW, Stack MV (eds) Tooth enamel. Proceedings of the international symposium, London. Wright & Sons, Bristol, pp 20–22, 50–57Google Scholar
  9. 9.
    Fowler BO (1974) Inorg Chem 13:194CrossRefGoogle Scholar
  10. 10.
    Henisch HK (1970) Crystal growth in gels. Pennsylvania State University Press, University ParkGoogle Scholar
  11. 11.
    Mann S (1996) Biomimetic materials chemistry. VCH, WeinheimGoogle Scholar

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • S. F. Willigeroth
    • 1
    Email author
  • K. Beneke
    • 1
  • M. Hannig
    • 2
  • R. Zimehl
    • 1
  1. 1.Institute of Inorganic ChemistryChristian-Albrechts-University KielKielGermany
  2. 2.Department of Operative Dentistry and PeriodontologyAlbert-Ludwigs-UniversityFreiburgFreiburgGermany

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