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Biopolymers · PVA Hydrogels, Anionic Polymerisation Nanocomposites pp 1–36Cite as

Polynucleotide Analogues

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 153))

Abstract

Nucleic acids (DNAs and RNAs) are biopolymers, called polynucleotides as polymers of nucleotides. They have purine or pyrimidine bases and sugar rings connected by phosphodiester linkages. Polynucleotide analogues (PNAs) with modified polymer backbones and/or modified nucleic acid bases have been studied as model polymers for natural nucleic acids. In spite of their structural simplicity, PNAs have shown the property of base-stacking along the synthetic polymer backbones and even interacted with natural nucleic acids through base-pairing. Since biological activities of natural nucleic acids are indebted greatly to base-base interactions, PNAs are expected to have certain types of biological activities. In this article the preparation methods, properties, and potential applications of PNAs are discussed.

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Authors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, 442-749, Korea

    Man Jung Han

  2. School of Materials Science and Engineering, Hyperstructured Organic Materials Research Center, Seoul National University, Seoul, 151-742, Korea

    Ji Young Chang

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  1. Man Jung Han
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  2. Ji Young Chang
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© 2000 Springer-Verlag Berlin Heidelberg

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Han, M.J., Chang, J.Y. (2000). Polynucleotide Analogues. In: Biopolymers · PVA Hydrogels, Anionic Polymerisation Nanocomposites. Advances in Polymer Science, vol 153. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-46414-X_1

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  • DOI: https://doi.org/10.1007/3-540-46414-X_1

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  • Print ISBN: 978-3-540-67313-2

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