Abstract
We present the development of an innovative device (Stem Cell Harvesting Manipulator) to get hematopoietic stem cells for bone marrow transplantation. By using this manipulator, stem cells are harvested from the iliac bone of the donor with minimal puncture. Additionally, the time for carrying out harvesting and the contamination of T cells can be minimized. In this paper, we report the development of a prototype of the Stem Cell Harvesting Manipulator with Flexible Drilling Unit. The manipulator is inserted into the medullary space from the iliac crest and aspirates the bone marrow while an end-mill on the tip of the Flexible Drilling Unit drills through cancellous bone to create a curved path. We found that the manipulator can be inserted into the medullary space of the pig iliac bone 131 mm by 32.1 mm/min and harvests a phantom of bone marrow about 6 times as much in mass as the conventional Aspiration Method. Further consideration regarding whether or not this device can harvest viable hematopoietic stem cells should be considered through experiments using laboratory animals.
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
E. D. Thomas: Does bone marrow transplantation confer a normal life span., N. Engl. J. of Med. (1999) 341, pp. 50–51
J. M. Rowe, H. M. Lazarus and A. M. Carella: Handbook of Bone Marrow Transplantation, Martin Dunitz, London (1997) vii
S. J. Forman, K. G. Blume and E. D. Thomas: Bone Marrow Transplantation, Blackwell Scientific Publications, Boston (1999) ch.21, pp. 259–269
T. Kushida, M. Inaba, K. Ikebukuro, T. Nagahama, H. Oyaizu, H. Lee, T. Ito, N. Ichioka, H. Hisha, K. Sugiura, S. Miyashima, N. Ageyama, F. Ono, H. Iida, R. Ogawa and S. Ikehara: “A New Method for Bone Marrow Cell Harvesting”, Stem Cells, Vol. 18, No. 6 (2000) pp. 453–456
K. Ohashi, T. Shibata, N. Hata, N. Yahagi, T. Matsumura, E. Kobayashi, I. Sakuma and T. Dohi: “Development of Minimally Invasive Bone Marrow Cell Harvester”, Proc. of The 10th Meeting of JSCAS (2001) pp. 101
H. J. Deeg, H.-G. Klingemann, G. L. Phillips and G. Van Zant: A Guide to Blood and Marrow Transplantation 3rd edn, Springer-Verlag, Berlin Heidelberg (1999) ch. 2, pp. 75–80
Islam: Manial of Bone Marrow Examination, harwood academic publishers, Amsterdam (1990) ch. 2, pp. 5–29
P. Dario: A Novel Mechatronic Tool for Computer-Assisted Arthroscopy, IEEE Trans. on Information Technology in Biomedicine Vol. 4, No. 1 (2000) pp. 15–28
R. Nakamura, T. Oura, E. Kobayashi, I. Sakuma, T. Dohi, N. Yahagi, T. Tsuji, D. Hashimoto, M. Shimada and M. Hashizume: Multi-DOF Forceps Manipulator System for Lapa-roscopic Surgery, Proc. of 4th MICCAI (2001) pp. 606–613
P. Dario, C. Paggetti, N. Troisfontaine, E. Papa, T. Ciucci, M. C. Carrozza and M. Marcacci: A miniature steerable end-effector for application in an integrated system for computer-assisted arthroscopy, Proc. of ICRA Vol. 2 (1997) pp. 1573–1579
T. Fukuda, S. Guo, K. Kosuge, F. Arai, M. Negoro and K. Nakabayashi: Micro active catheter system with multi degrees of freedom, Proc. of ICRA (1994) pp. 2290–2295
H. Rininsland: ARTEMIS. A telemanipulator for cardiac surgery, Europian J. of Cardio-thoracic Surgery 16 Suppl.2, (1999) pp. s106–s111
K. Ikuta, T. Kato, S. Nagata: Micro active forceps with optical fiber scope for intra-ocular microsurgery, Proc. of the IEEE MEMS (1996) pp. 456–461
S. Itoh: Bull. of Japan Society of Mechanical Engineers 26-222 (1983) pp. 2295
V. G. Kaburlasos, V. Petridis, P. Brett and D. Baker: Learning a linear association of drilling profiles in stapedotomy surgery, Proc. of ICRA Vol. 1 (1998) pp. 705–709
J. Jaroscak: A phase 1 trial of augment of unrelated umbilical cord blood transplantation with ex-vivo expanded cells, Blood Suppl.1, (1998) pp. 646a
X. Sui: gp130 and c-Kit signalings synergize for ex vivo expansion of human primary hematopoietic progenitor cells, Proc. of Natl. Acad. Sci. USA 92 (1995) pp. 2859–2863
M. Marmont: Immune ablation followed by allogeneic or autologous bone marrow transplantation: a new treatment for severe autoimmune diseases?, Stem Cells Vol. 12 (1994) pp. 125–135
J. Kohyama, H. Abe, T. Shimazaki, A. Koizumi, K. Nakashima, S. Gojo, T. Taga, H. Okano, J. Hata and A. Umezawa: Brain from bone: efficient “meta-differentiation” of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent., Differentiation Oct;68(4-5) (1996) pp. 235–44
P. Bianco, M. Riminucci, S. Gronthos, PG. Robey: Bone marrow stromal stem cells: nature, biology, and potential applications, Stem Cells, 19(3) (2001) pp. 180–92
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ohashi, K., Hata, N., Matsumura, T., Yahagi, N., Sakuma, I., Dohi, T. (2002). A Stem Cell Harvesting Manipulator with Flexible Drilling Unit for Bone Marrow Transplantation. In: Dohi, T., Kikinis, R. (eds) Medical Image Computing and Computer-Assisted Intervention — MICCAI 2002. MICCAI 2002. Lecture Notes in Computer Science, vol 2488. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45786-0_24
Download citation
DOI: https://doi.org/10.1007/3-540-45786-0_24
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44224-0
Online ISBN: 978-3-540-45786-2
eBook Packages: Springer Book Archive