Skip to main content
SpringerLink
Log in

Degradable Polymer Microspheres for Controlled Drug Delivery

  • Chapter
  • First Online:
Degradable Aliphatic Polyesters

Part of the book series: Advances in Polymer Science ((POLYMER,volume 157))

Abstract

Controlled drug delivery technology is concerned with the systematic release of a pharmaceutical agent to maintain a therapeutic level of the drug in the body for a sustained period of time. This may be achieved by incorporating the therapeutic agent into a degradable polymer vehicle, releasing the agent continuously as the matrix erodes. This review is concerned with degradable polymers for use in controlled drug delivery with emphasis on the preparation, applications, biocompatibility, and stability of microspheres from hydrolytically degradable polymers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wichterle O, Lim D (1960) Nature 185:117

    Article  Google Scholar 

  2. Folkman J, Long DM, Rosenbaum R (1966) Science 154:148

    Article  CAS  Google Scholar 

  3. Kulkarni RK, Pani KC, Neuman C, Leonard F (1966) Arch Surg 93:839

    CAS  Google Scholar 

  4. Schmitt EE, Polistina RA (1969) US Patent 3,463,158

    Google Scholar 

  5. Schneider AK (1972) US Patent 3,636,956

    Google Scholar 

  6. Frazza EJ, Schmitt EE (1971) J Biomed Mater Res Symp 1:43

    Article  Google Scholar 

  7. Wasserman D, Versfelt CC (1974) US Patent 3,839,297

    Google Scholar 

  8. Benicewicz BC, Hopper PK (1990) J Bioact Compat Polym 5:453

    Article  CAS  Google Scholar 

  9. Brady JM, Cutright DE, Miller RA, Battistone GC, Hunsuck EE (1973) J Biomed Mater Res 7:155

    Article  CAS  Google Scholar 

  10. Bos RRM, Rozema FR, Boering G, Nijenhuis AJ, Pennings AJ, Verwey AB, Nieuwenhuis P, Jansen HWB (1991) Biomaterials 12:32

    Article  CAS  Google Scholar 

  11. Vainionpää S, Rokkanen P, Törmälä P (1989) Prog Polym Sci 14:679

    Article  Google Scholar 

  12. Leenslag JW, Pennings AJ, Bos RRM, Rozema FR, Boering G (1987) Biomaterials 8:311

    Article  CAS  Google Scholar 

  13. Vert M (1989) Angew Makromol Chem 166/167:155

    Google Scholar 

  14. Gogolewski S, Pennings AJ (1983) Makromol Chem Rapid Commun 4:675

    Article  CAS  Google Scholar 

  15. Kronenthal RL (1975) Biodegradable polymers in medicine and surgery. In: Kronenthal RL, Oser Z, Martin E (eds), Polymers in medicine and surgery. Plenum Press, New York, p 119

    Google Scholar 

  16. Yolles S, Eldridge JE, Woodland JHR (1971) Polym News 1:9

    CAS  Google Scholar 

  17. Yolles S (1975) Polym Sci Technol 8:245

    CAS  Google Scholar 

  18. Higuchi T (1971) US Patent 3,625,214

    Google Scholar 

  19. Wise DL, McCormick GJ, Willet GP (1976) Life Sciences 19:867

    Article  CAS  Google Scholar 

  20. Schindler A, Jeffcoat R, Kimmel GL, Pitt CG, Wall ME, Zweidinger R (1977) Cont Topics Polym Sci 2:251

    CAS  Google Scholar 

  21. Beck LR, Cowsar DR, Lewis DH, Gibson JW, Flowers CE (1979) Am J Obstet Gynecol 135:419

    CAS  Google Scholar 

  22. Michaels AS (1976) US Patent 3,962,414

    Google Scholar 

  23. Heller J, Baker RW, Gale RM, Rodin JO (1978) J Appl Polym Sci 22:1991

    Article  CAS  Google Scholar 

  24. Heller J (1984) Crit Rev Ther Drug Carrier Syst 1:39

    CAS  Google Scholar 

  25. Baker RW, Lonsdale HK (1975) Chem Tech 5:668

    CAS  Google Scholar 

  26. Ottenbrite RM (1990) Controlled release technology. In: Kroschwitz JI (ed), Encyclopedia of Polymer Science and Engineering, Volume Suppl Vol. Wiley, New York, p 164

    Google Scholar 

  27. Peppas NA (1987) Hydrogels in Medicine and Pharmacy, Vol II Polymers. CRC Press, Boca Raton

    Google Scholar 

  28. Chasin M, Langer R (1990) Biodegradable polymers as drug delivery systems. Marcel Dekker, New York

    Google Scholar 

  29. World market research centre (2000) Business briefing: PharmaTech

    Google Scholar 

  30. Davis SS, Illum L, Stolnik S (1996) Curr Opinion Coll Int Sci 1:660

    CAS  Google Scholar 

  31. Okada H, Ogawa Y, Yashiki T (1987) US Patent 4,652,441

    Google Scholar 

  32. Okada H, Yamamoto M, Heya T, Inoue Y, Kamei S, Ogawa Y, Toguchi H (1994) J Control Rel 28:121

    Article  CAS  Google Scholar 

  33. Göpferich A (1996) Biomaterials 17:103

    Article  Google Scholar 

  34. Albertsson A-C, Karlsson S (1994) Chemistry and biochemistry of polymer biodegradation. In: Griffin GJL (ed), Chemistry and Technology of Biodegradable Polymers. Blackie, Glasgow, chap 2, p 7

    Google Scholar 

  35. Lenz RW (1993) Adv Polym Sci 107:1

    Article  CAS  Google Scholar 

  36. Albertsson A-C, Karlsson S (1995) Acta Polym 46:114

    Article  CAS  Google Scholar 

  37. Amass W, Amass A, Tighe B (1998) Polym Int 47:89

    Article  CAS  Google Scholar 

  38. Li S, Vert M (1995) Biodegradation of aliphatic polyesters. In: Scott G, Gilead D (eds), Degradable polymers. Chapman & Hall, London, chap 4, p 43

    Google Scholar 

  39. Kopecek J, Ulbrich K (1983) Prog Polym Sci 9:1

    Article  CAS  Google Scholar 

  40. Matlaga BF, Yasenchak LP, Salthouse TN (1976) J Biomed Mater Res 10:391

    Article  CAS  Google Scholar 

  41. Makino K, Ohshima H, Kondo T (1986) J Microencapsulation 3:203

    Article  CAS  Google Scholar 

  42. Tamada JA, Langer R (1993) Proc Natl Acad Sci 90:552

    Article  CAS  Google Scholar 

  43. Göpferich A (1997) Macromolecules 30:2598

    Article  Google Scholar 

  44. Siegel RA, Pitt CG (1995) J Control Rel 33:173

    Article  CAS  Google Scholar 

  45. Medlicott NJ, Tucker IG (1999) Adv Drug Delivery Rev 38:139

    Article  CAS  Google Scholar 

  46. Juliano RL (1978) Can J Physiol Pharmacol 56:683

    CAS  Google Scholar 

  47. Fan LT, Singh SK (1989) Controlled release, a quantitative treatment. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  48. Ranade VV (1991) J Clin Pharmacol 3:401

    Google Scholar 

  49. Chandrasekaran SK, Shaw JE (1977) Con Top in Polym Sci 2:291

    CAS  Google Scholar 

  50. Singh P, Maibach HI (1994) Crit Rev Ther Drug 11:161

    CAS  Google Scholar 

  51. Gupta SK, Kumar S, Bolton S, Behl CR, Malick AW (1994) J Control Rel 30:253

    Article  CAS  Google Scholar 

  52. Vanbever R, Lecouturier N, Preat V (1994) Pharm Res 11:1657

    Article  CAS  Google Scholar 

  53. Ringsdorf H (1975) J Polym Sci 51:135

    CAS  Google Scholar 

  54. Domb A, Amselem S, Shah J, Maniar M (1992) Polym Adv Technol 3:279

    Article  CAS  Google Scholar 

  55. Duncan R, Dimitrijevic S, Evagorou EG (1996) STP Pharm Sci 6:237

    Google Scholar 

  56. Ouchi T, Ohya Y (1995) Prog Polym Sci 20:211

    Article  CAS  Google Scholar 

  57. Oku N (1991) Liposomes. In: Dunn RL, Ottenbrite RM (eds), Polymeric drugs and drug delivery systems. ACS Symp Series 469, chap 3, p 24

    Google Scholar 

  58. Dunn RL (1991) Polymeric matrices. In: Dunn RL, Ottenbrite RM (eds), Polymeric drugs and drug delivery systems. ACS Symp Series 469, chap 2, p 11

    Google Scholar 

  59. Wood DA (1980) Int J Pharm 7:1

    Article  CAS  Google Scholar 

  60. Langer R, Peppas NA (1981) Biomaterials 2:201

    Article  CAS  Google Scholar 

  61. Holland SJ, Tighe BJ, Gould PL (1986) J Control Rel 4:155

    Article  CAS  Google Scholar 

  62. Brannon-Peppas L (1995) Int J Pharm 116:1

    Article  CAS  Google Scholar 

  63. Allémann E, Leroux J-C, Gurny R (1998) Adv Drug Delivery Rev 34:171

    Article  Google Scholar 

  64. Wang YM, Sato H, Horikoshi I (1997) J Control Rel 49:157

    Article  CAS  Google Scholar 

  65. Beck LR, Flowers CF, Cowsar DR, Tanquary AC (1988) US Patent 4,732,763

    Google Scholar 

  66. O'Hagan DT (1998) Adv Drug Del Rev 34:305

    Article  CAS  Google Scholar 

  67. Sturesson C, Artursson P, Ghaderi R, Johansen K, Mirazimi A, Uhnoo I, Svensson L, Albertsson A-C, Carlfors J (1999) J Control Rel 59:377

    Article  CAS  Google Scholar 

  68. Jalil R, Nixon JR (1990) J Microencapsulation 7:297

    Article  CAS  Google Scholar 

  69. Schmitt EA, Flanagan DR, Linhardt RJ (1994) Macromolecules 27:743

    Article  CAS  Google Scholar 

  70. Higuchi T (1961) J Pharm Sci 50:874

    Article  CAS  Google Scholar 

  71. Ritger PL, Peppas NA (1987) J Control Rel 5:23

    Article  CAS  Google Scholar 

  72. Wada R, Hyon S-H, Ikada Y.(1995) J Control Rel 37:151

    Article  CAS  Google Scholar 

  73. Batycky RP, Hanes J, Langer R, Edwards DA (1997) J Pharm Sci 86:1464

    Article  CAS  Google Scholar 

  74. Yoshida R, Sakai K, Okano T, Sakurai Y (1991) Polym J 23:1111

    Article  CAS  Google Scholar 

  75. Leong KW, Brott BC, Langer R (1985) J Biomed Mater Res 19:941

    Article  CAS  Google Scholar 

  76. Li Y-X, Feng X-D (1990) Makromol Chem Makromol Symp 33:253

    CAS  Google Scholar 

  77. Heller J (1980) Biomaterials 1:51

    Article  CAS  Google Scholar 

  78. Szycher M (1992) Szycher’s Dictionary of Biomaterials and Medical Devices. Technomic Publishing Company, Lancaster

    Google Scholar 

  79. Williams DF (1989) J Biomed Eng 11:185

    Article  CAS  Google Scholar 

  80. Merkli A, Heller J, Tabatabay C, Gurny R (1996) Biomaterials 17:897

    Article  CAS  Google Scholar 

  81. Anderson JM, Langone JJ (1999) J Control Rel 57:107

    Article  CAS  Google Scholar 

  82. Edlund U, Albertsson A-C, Singh SK, Fogelberg I, Lundgren BO (2000) Biomaterials 21:945

    Article  CAS  Google Scholar 

  83. Zignani M, Bernatchez SF, Le Minh T, Tabatabay C, Anderson JM, Gurny R (1998) J Biomed Mater Res 39:277

    Article  CAS  Google Scholar 

  84. Sakellariou P, Rowe RC (1995) Prog Polym Sci 20:889

    Article  CAS  Google Scholar 

  85. Pereswetoff-Morath L (1998) Adv Drug Del Rev 29:185

    Article  CAS  Google Scholar 

  86. Rege PR, Shukla DJ, Block LH (1999) Int J Pharm 181:49

    Article  CAS  Google Scholar 

  87. Lorenzo-Lamosa ML, Remunan-Lopez C,V ila-Jato JL, Alonso MJ (1998) J Control Rel 52:109

    Article  CAS  Google Scholar 

  88. Fujioka K, Maeda M, Hojo T, Sano A (1998) Adv Drug Delivery Rev 31:247

    Article  CAS  Google Scholar 

  89. Tabata Y, Ikada Y (1998) Adv Drug Delivery Rev 31:287

    Article  CAS  Google Scholar 

  90. Lewis DH (1990) Controlled release of bioactive agents from lactide/glycolide polymers. In: Chasin M, Langer R (eds), Biodegradable polymers as drug delivery systems. Marcel Dekker, New York, chap 1, p 1

    Google Scholar 

  91. Grandfils C, Flandroy P, Nihant N, Barbette S, Jérome R, Teyssié Ph, Thibaut A (1992) J Biomed Mater Res 26:467

    Article  CAS  Google Scholar 

  92. Kricheldorf HR, Kreiser-Saunders I (1996) Macromol Symp 103:85

    CAS  Google Scholar 

  93. Zhang X, Wyss UP, Pichora D, Goosen MFA (1994) J Bioact Compat Polym 9:80

    Article  CAS  Google Scholar 

  94. Polard E, Le Corre P, Chevanne F, Le Verge R (1996) Int J Pharm 134:37

    Article  CAS  Google Scholar 

  95. Vert M, Li SM, Spenlehauer, G, Guerin P (1992) J Mater Sci Mater Med 3:432

    Article  CAS  Google Scholar 

  96. Heya T, Okada H, Ogawa Y, Toguchi H (1991) Int J Pharm 72:199

    Article  CAS  Google Scholar 

  97. Chiu LK, Chiu WJ, Cheng Y-L (1995) Int J Pharm 126:169

    Article  CAS  Google Scholar 

  98. Cohen S, Chen L, Apte RN (1995) Reactive Polym 25:177

    Article  CAS  Google Scholar 

  99. Crotts G, Park TG (1998) J Microencapsulation 15:699

    Article  CAS  Google Scholar 

  100. Cheng Y-H, Illum L, Davis SS (1998) J Control Rel 55:203

    Article  CAS  Google Scholar 

  101. Coombes AGA, Yeh M-K, Lavelle EC, Davis SS (1998) J Control Rel 52:311

    Article  CAS  Google Scholar 

  102. Cao X, Shoichet MS (1999) Biomaterials 20:329

    Article  CAS  Google Scholar 

  103. Castelli F, Giunchedi P, LaCamera O, Conte U (2000) Drug Delivery 7:1

    Article  Google Scholar 

  104. Chandrashekar G, Udupa N (1996) J Pharm Pharmacol 48:669

    CAS  Google Scholar 

  105. Dubernet C, Benoit JP, Couarraze G, Duchêne D (1987) Int J Pharm 35:145

    Article  CAS  Google Scholar 

  106. Pitt CG (1990) Poly-e-caprolactone and its copolymers. In: Chasin M, Langer R (eds), Biodegradable polymers as drug delivery systems. Marcel Dekker, New York, chap 3, p 71

    Google Scholar 

  107. Pouton CW, Akhtar S (1996) Adv Drug Del Syst 18:133

    Article  CAS  Google Scholar 

  108. Martin MA, Miguens FC, Rieumont J, Sanchez R (2000) Coll Surf B 17:111

    Article  CAS  Google Scholar 

  109. Nobes GAR, Marchessault RH, Maysinger D (1998) Drug Delivery 5:167

    CAS  Google Scholar 

  110. Holland SJ, Jolly AM, Yasin M, Tighe BJ (1987) Biomaterials 8:289

    Article  CAS  Google Scholar 

  111. Chasin M, Domb A, Ron E, Mathiowitz E, Langer R, Leong K, Laurencin C, Brem H, Grossman S (1990) Polyanhydrides as drug delivery systems. In: Chasin M, Langer R (eds), Biodegradable Polymers as Drug Delivery Systems. Marcel Dekker, New York, chap 2, p 43

    Google Scholar 

  112. Leong KW, D’Amore P, Marletta M, Langer R (1986) J Biomed Mater Res 20:51

    Article  CAS  Google Scholar 

  113. Mathiowitz E, Amato C,D or Ph, Langer R (1990) Polymer 31:547

    Article  CAS  Google Scholar 

  114. Maniar M, Domb A, Haffer A, Shah J (1994) J Control Rel 30:233

    Article  CAS  Google Scholar 

  115. Wu MP, Tamada JA, Brem H, Langer R (1994) J Biomed Mater Res 28:387

    Article  CAS  Google Scholar 

  116. Park E-S, Maniar M, Shah JC (1997) J Control Rel 48:67

    Article  CAS  Google Scholar 

  117. Mathiowitz E, Jacob JS, Jong YS, Carino GP, Chickering DE, Chaturvedi P, Santos CA, Vijayaraghavan K, Montgomery S, Basset M, Morrell C (1997) Nature 386:410

    Article  CAS  Google Scholar 

  118. Chickering D, Jacob J, Mathiowitz E (1996) Biotech Bioeng 52:96

    Article  CAS  Google Scholar 

  119. Leach KJ, Takahashi S, Mathiowitz E (1998) Biomaterials 19:1981

    Article  CAS  Google Scholar 

  120. Zhu KJ, Hendren RW, Jensen K, Pitt CG (1991) Macromolecules 24:1736

    Article  CAS  Google Scholar 

  121. Edlund U, Albertsson A-C (1999) J Appl Polym Sci 72:227

    Article  CAS  Google Scholar 

  122. Heller J (1985) J Control Rel 2:167

    Article  CAS  Google Scholar 

  123. Sparer RV, Shih C, Ringeisen CD, Himmelstein KJ (1984) J Control Rel 1:23

    Article  CAS  Google Scholar 

  124. Maa YF, Heller J (1990) J Control Rel 14:21

    Article  CAS  Google Scholar 

  125. Heller J, Chang AC, Rodd G, Grodsky GM (1990) J Control Rel 13:295

    Article  CAS  Google Scholar 

  126. Heller J, Ng SY, Fritzinger BK, Roskos KV (1990) Biomaterials 11:235

    Article  CAS  Google Scholar 

  127. Roskos KV, Fritzinger BK, Rao SS, Armitage GC, Heller J (1995) Biomaterials 16:313

    Article  CAS  Google Scholar 

  128. Zignani M, Merkli A, Sintzel MB, Bernatchez SF, Kloeti W, Heller J, Tabatabay C, Gurny R (1997) J Control Rel 48:115

    Article  CAS  Google Scholar 

  129. Edlund U, Albertsson A-C (1999) J Polym Sci A Polym Chem 37:1877

    Article  CAS  Google Scholar 

  130. Edlund U, Albertsson A-C (2000) J Polym Sci A Polym Chem 38:786

    Article  CAS  Google Scholar 

  131. Edlund U, Albertsson A-C (2000) J Bioact Compat Polym 15:214

    Article  CAS  Google Scholar 

  132. Cook TJ, Amidon GL, Yang VC (1997) Int J Pharm 159:197

    Article  CAS  Google Scholar 

  133. Kim KS, Kim TK, Graham NB (1999) Polym J 31:813

    Article  CAS  Google Scholar 

  134. Zhao X, Harris JM (1998) J Pharm Sci 87:1450

    Article  CAS  Google Scholar 

  135. La SB, Nagasaki Y, Kataoka K (1997) ACS Symp Ser 680:99

    Article  CAS  Google Scholar 

  136. Lu S, Anseth KS (2000) Macromolecules 33:2509

    Article  CAS  Google Scholar 

  137. Bae YH, Huh KM, Kim Y, Park K-H (2000) J Control Rel 64:3

    Article  CAS  Google Scholar 

  138. Schacht E, Vandorpe J, Dejardin S, Lemmouchi Y, Seymour L (1996) Biotechnol Bioeng 52:102

    Article  CAS  Google Scholar 

  139. Ibim SM, Ambrosio AA, Larrier D, Allcock HR, Laurencin CT (1996) J Control Rel 40:31

    Article  CAS  Google Scholar 

  140. Andrianov AK, Payne LG (1998) Adv Drug Delivery Rev 31:185

    Article  CAS  Google Scholar 

  141. Domb AJ (1993) J Polym Sci A Polym Chem 31:1973

    Article  CAS  Google Scholar 

  142. Carothers WH, Arvin GA (1929) J Am Chem Soc 51:2560

    Article  CAS  Google Scholar 

  143. Pitt CG, Gratzl MM, Kimmel GL, Surles J, Schindler A (1981) Biomaterials 2:215

    Article  CAS  Google Scholar 

  144. Grijpma DW, Pennings AJ (1994) Macromol Chem Phys 195:1633

    Article  CAS  Google Scholar 

  145. Tsuji H, Ikada Y (2000) Polym Degr Stab 67:179

    Article  CAS  Google Scholar 

  146. Williams DF (1981) Eng Med 10:5

    Article  Google Scholar 

  147. Pitt CG, Gu Z (1987) J Control Rel 4:283

    Article  CAS  Google Scholar 

  148. Pistner H, Gutwald R., Ordung R, Reuther J, Mühling J (1993) Biomaterials 14:671

    Article  CAS  Google Scholar 

  149. Lundberg RD, Cox EF (1969) Lactones. In: Frisch KC, Reegen SL (eds), Ring-opening polymerization. Marcel Dekker, New York, chap 6, p 247

    Google Scholar 

  150. Löfgren A, Albertsson A-C, Dubois Ph, Jérôme R (1995) J Macromol Sci Rev Macromol Chem Phys C 35:379

    Google Scholar 

  151. Albertsson A-C, Ljungquist O (1986) J Macromol Sci Chem A 23:393

    Article  Google Scholar 

  152. Albertsson A-C, Ljungquist O (1988) Acta Polym 39:95

    Article  CAS  Google Scholar 

  153. Mathisen T, Masus K, Albertsson A-C (1989) Macromolecules 22:3842

    Article  CAS  Google Scholar 

  154. Löfgren A, Albertsson A-C (1995) J Macromol Sci Pure Appl Chem A 32:41

    Article  Google Scholar 

  155. Gruvegård M, Lindberg T, Albertsson A-C (1998) J Macromol Sci Pure Appl Chem A 35:885

    Article  Google Scholar 

  156. Stridsberg K, Gruvegård M, Albertsson A-C (1998) Macromol Symp 130:367

    CAS  Google Scholar 

  157. Stridsberg K, Ryner M, Albertsson A-C (2000) Macromolecules 33:2862

    Article  CAS  Google Scholar 

  158. Brode GL, Koleske JV (1972) J Macromol Sci Chem A 6:1109

    Article  CAS  Google Scholar 

  159. Dubois Ph, Ropson N, Jérôme R, Teyssié Ph (1996) Macromolecules 29:1965

    Article  CAS  Google Scholar 

  160. Jedlinski Z, Kurcok P, Kowalczuk M, Matuszowicz A, Dubois P, Jerome R, Kricheldorf HR (1995) Macromolecules 28:7276

    Article  CAS  Google Scholar 

  161. Kreiser-Saunders I, Kricheldorf HR (1998) Macromol Chem Phys 199:1081

    CAS  Google Scholar 

  162. Kricheldorf HR, Kreiser-Saunders I, Boettcher C (1995) Polymer 36:1253

    Article  CAS  Google Scholar 

  163. Kricheldorf HR, Eggerstedt S (1998) Macromol Chem Phys 199:283

    CAS  Google Scholar 

  164. Kowalski A, Duda A, Penczek S (1998) Macromol Rapid Commun 19:567

    CAS  Google Scholar 

  165. Stevels WM, Ankoné MJK, Dijkstra PJ, Feijen J (1996) Macromolecules 29:6132

    Article  CAS  Google Scholar 

  166. Deng XM, Yuan ML, Xiong CD, Li XH (1999) J Appl Polym Sci 71:1941

    Article  CAS  Google Scholar 

  167. Simic V, Girardon V, Spassky N, Hubert-Pfalzgraf LG, Duda A (1998) Polym Degr Stab 59:227

    Article  CAS  Google Scholar 

  168. Chamberlain BM, Sun Y, Hagadorn JR, Hemmesch EW, Young VG, Pink M, Hillmyer MA, Tolman WB (1999) Macromolecules 32:2400

    Article  CAS  Google Scholar 

  169. Mecerreyes D, Jérôme R (1999) Macromol Chem Phys 200:2581

    Article  CAS  Google Scholar 

  170. Vert M, Schwarch G Coudane J (1995) J Macromol Sci Pure Appl Chem A 32:787

    Article  Google Scholar 

  171. Kobayashi S, Uyama H, Namekawa S (1998) Polym Degr Stab 59:195

    Article  CAS  Google Scholar 

  172. Dong H, Cao S-G, Li Z-Q, Han S-P, You D-L, Shen J-C (1999) J Polym Sci A Polym Chem 37:1265

    Article  CAS  Google Scholar 

  173. Henderson LA, Svirkin YY, Gross RA, Kaplan DL, Swift G (1996) Macromolecules 29:7759

    Article  CAS  Google Scholar 

  174. Matsumura S, Mabuchi K, Toshima K (1998) Macromol Symp 130:285

    CAS  Google Scholar 

  175. Kulkarni RK, Moore EG, Hegyeli AF, Leonard F (1971) J Biomed Mater Res 5:169

    Article  CAS  Google Scholar 

  176. Thérin M, Christel P, Li S, Garreau H, Vert M (1992) Biomaterials 13:594

    Article  Google Scholar 

  177. Engelberg I, Kohn J (1991) Biomaterials 12:292

    Article  CAS  Google Scholar 

  178. Lunt J (1998) Polym Degr Stab 59:145

    Article  CAS  Google Scholar 

  179. Gilding DK, Reed AM (1979) Polymer 20:1459

    Article  CAS  Google Scholar 

  180. Feng X-D, Jia Y (1997) Macromol Symp 118:625

    CAS  Google Scholar 

  181. Spenlehauer G, Vert M, Benoît J-P, Chabot F, Veillard M (1988) J Control Rel 7:217

    Article  CAS  Google Scholar 

  182. Duda A, Biela T, Libiszowski J, Penczek S, Dubois P, Mecerreyes D, Jérôme R (1998) Polym Degr Stab 59:215

    Article  CAS  Google Scholar 

  183. Li SM, Rashkov I, Espartero JL, Manolova N, Vert M (1996) Macromolecules 29:57

    Article  CAS  Google Scholar 

  184. Yasugi K, Nagasaki Y, Kato M, Kataoka K (1999) J Control Rel 62:89

    Article  CAS  Google Scholar 

  185. Metters AT, Anseth KS, Bowman CN (2000) Polymer 41:3993

    Article  CAS  Google Scholar 

  186. Kim J-H, Emoto K, Iijima M, Nagasaki Y, Aoyagi T, Okano T, Sakurai Y, Kataoka K (1999) Polym AdvTechnol 10:647

    CAS  Google Scholar 

  187. Tsuji H, Ikada Y (1998) J Appl Polym Sci 67:405

    Article  CAS  Google Scholar 

  188. Cha Y, Pitt CG (1988) J Control Rel 7:69

    Article  CAS  Google Scholar 

  189. Seki T, Kawaguchi T, Endoh H, Ishikawa K, Juni K, Nakano M (1990) J Pharm Sci 79:985

    Article  CAS  Google Scholar 

  190. Aso Y, Yoshioka S, Terao T (1993) Int J Pharm 93:153

    Article  CAS  Google Scholar 

  191. Leo E, Forni F, Bernabei MT (2000) Int J Pharm 196:1

    Article  CAS  Google Scholar 

  192. Gander B, Johansen P, Nam-Trân H, Merkle HP (1996) Int J Pharm 129:51

    Article  CAS  Google Scholar 

  193. Luo D, Woodrow-Mumford K, Belcheva N, Saltzman WM (1999) Pharm Res 16:1300

    Article  CAS  Google Scholar 

  194. Reed AM, Gilding DK (1981) Polymer 22:494

    Article  CAS  Google Scholar 

  195. Tuncay M, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA (2000) Int J Pharm 195:179

    Article  CAS  Google Scholar 

  196. Yang J, Cleland JL (1997) J Pharm Sci 86:908

    Article  CAS  Google Scholar 

  197. Park TG, Lee HY, Nam YS (1998) J Control Rel 55:181

    Article  CAS  Google Scholar 

  198. Kim HK, Park TG (1999) Biotech Bioeng 65:659

    Article  CAS  Google Scholar 

  199. Péan J-M, Venier-Julienne M-C, Boury F, Menei P, Denizot B, Benoit J-P (1998) J Control Rel 56:175

    Article  Google Scholar 

  200. Maulding HV (1987) J Control Rel 6:167

    Article  CAS  Google Scholar 

  201. Sah H, Toddywala R, Chien YW (1995) J Control Rel 35:137

    Article  CAS  Google Scholar 

  202. Blanco-Prieto MJ, Besseghir K, Zerbe O, Andris D, Orsolino P, Heimgartner F, Merkle HP, Gander B (2000) J Control Rel 67:19

    Article  CAS  Google Scholar 

  203. Metha RC, Thanoo BC, DeLuca PP (1996) J Control Rel 41. 249

    Article  Google Scholar 

  204. Thompson WW, Anderson DB, Heiman ML (1997) J Control Rel 43:9

    Article  CAS  Google Scholar 

  205. Walter E, Moelling K, Pavlovic J, Merkle HP (1999) J Control Rel 61:361

    Article  CAS  Google Scholar 

  206. Tinsley-Bown AM, Fretwell R, Dowsett AB, Davis SL, Farrar GH (2000) J Control Rel 66:229

    Article  CAS  Google Scholar 

  207. Wang D, Robinson DR, Kwon GS, Samuel J (1999) J Control Rel 57:9

    Article  CAS  Google Scholar 

  208. Ertl B, Plazer P, Wirth M, Gabor F (1999) J Control Rel 61. 305

    Article  CAS  Google Scholar 

  209. Mohr D, Wolff M, Kissel T (1999) J Control Rel 61:203

    Article  CAS  Google Scholar 

  210. Birnbaum DT, Kosmala JD, Henthorn DB, Brannon-Peppas L (2000) J Control Rel 65:375

    Article  CAS  Google Scholar 

  211. Mogi T, Ohtake N, Yoshida M, Chimura R, Kamaga Y, Ando S, Tsukamoto T, Nakajima T, Uenodan H, Otsuka M, Matsuda Y, Ohshima H, Makino K (2000) Colloid Surface B 17:153

    Article  CAS  Google Scholar 

  212. Philips M, Gresser JD (1984) J Pharm Sci 73:1718

    Article  Google Scholar 

  213. Stoller NH, Johnson LR, Trapnell S, Harrold CQ, Garett S (1998) J Periodontol 69:1085

    CAS  Google Scholar 

  214. Benedict CV, Cameron JA, Huang SJ (1983) J Appl Polym Sci 28:335

    Article  CAS  Google Scholar 

  215. Eldsäter C, Erlandsson B, Renstad R, Albertsson A-C, Karlsson S (2000) Poylmer 41:1297

    Article  Google Scholar 

  216. Rutkowska M, Dereszewska A, Jastrzebska M, Janik H (1998) Macromol Symp 130:199

    CAS  Google Scholar 

  217. Chen DR, Bei JZ, Wang SG (2000) Polym Degr Stab 67:455

    Article  CAS  Google Scholar 

  218. Lemmouchi Y, Schacht E, Kageruka P, De Deken R, Diarra B, Diall O, Geerts S (1998) Biomaterials 19:1827

    Article  CAS  Google Scholar 

  219. Lostocco MR, Murphy CA, Cameron JA, Huang SJ (1998) Polym Degr Stab 59:303

    Article  CAS  Google Scholar 

  220. Tian D, Dubios Ph, Jerome R (1996) Polymer 37:3983

    Article  CAS  Google Scholar 

  221. Eastmond GC (1999) Adv Polym Sci 149:59

    Article  CAS  Google Scholar 

  222. Perez MH, Zinutti C, Lamprecht A, Ubrich N, Astier A, Hoffman M, Bodmeier R, Maincent P (2000) J Control Rel 65:429

    Article  Google Scholar 

  223. Vandamme TF, Mukendi JFN (1996) Int J Pharm 145:77

    Article  CAS  Google Scholar 

  224. Jameela SR, Suma N, Jayakrishnan A (1997) J Biomater Sci Polym Ed 8:466

    Article  Google Scholar 

  225. Goodwin CJ, Braden M, Downes S, Marshall NJ (1998) J Biomed Mater Res 40:204

    Article  CAS  Google Scholar 

  226. Buntner B, Nowak M, Kasperczyk J, Ryba M, Grieb P, Walski M, Dobrzyñski P, Bero M (1998) J Control Rel 56:159

    Article  CAS  Google Scholar 

  227. Allen C, Han J, Yu Y, Maysinger D, Eisenberg A (2000) J Control Rel 63:275

    Article  CAS  Google Scholar 

  228. Merrick JM, Doudoroff M (1961) Nature 189:890

    Article  CAS  Google Scholar 

  229. Doi Y, Kunioka M, Nakamura Y, Soga K (1986) Macromolecules 19:1274

    Article  CAS  Google Scholar 

  230. Sharma R, Ray AR (1995) J Macromol Sci Rev Macromol Chem Phys C 35:327

    Google Scholar 

  231. Holmes PA (1985) Phys Technol 16:32

    Article  CAS  Google Scholar 

  232. Kawaguchi Y, Doi Y (1992) Macromolecules 25:2324

    Article  CAS  Google Scholar 

  233. Doi Y (1995) Macromol Symp 98:585

    CAS  Google Scholar 

  234. Doi Y (2000) Abstr Pap-IUPAC Macro 2000, July 2000, Warsaw, Poland 1:8

    Google Scholar 

  235. Gross RA, DeMello C, Lenz RW, Brandl H, Fuller RC (1989) Macromolecules 22:1106

    Article  CAS  Google Scholar 

  236. Eldsäter C, Albertsson A-C, Karlsson S (1997) Acta Polymer 48:478

    Article  Google Scholar 

  237. Miller ND, Williams DF Biomaterials (1987) 8:129

    Google Scholar 

  238. Holland SJ, Yasin M, Tighe BJ (1990) Biomaterials 11:206

    Article  CAS  Google Scholar 

  239. Yasin M, Tighe BJ (1992) Biomaterials 13:9

    Article  CAS  Google Scholar 

  240. Atkins TW (1997) Biomaterials 18:173

    Article  CAS  Google Scholar 

  241. Atkins TW, Peacock SJ (1996) J Microencapsulation 13:709

    Article  CAS  Google Scholar 

  242. Gangrade N, Price JC (1991) J Microencapsulation 8:185

    Article  CAS  Google Scholar 

  243. Sendil D, Gürsel I, Wise DL, Hasirci V (1999) J Control Rel 59:207

    Article  CAS  Google Scholar 

  244. Juni K, Nakano M, Kubota M (1986) J Control Rel 4:25

    Article  CAS  Google Scholar 

  245. Abe H, Doi Y, Yamamoto Y (1992) J Macromol Sci Pure Appl Chem 29:229

    Article  Google Scholar 

  246. Kawaguchi T, Tsugane A, Higashide K, Endoh H, Hasegawa T, Kanno H, Seki T, Juni K, Fukushima S, Nakano M (1992) J Pharm Sci 81:508

    Article  CAS  Google Scholar 

  247. Bucher JE, Slade WC (1909) J Am Chem Soc 31:1319

    Article  Google Scholar 

  248. Hill JW (1930) J Am Chem Soc 52:4110

    Article  CAS  Google Scholar 

  249. Mathiowitz E, Langer R (1987) J Control Rel 5:13

    Article  CAS  Google Scholar 

  250. Tamargo RJ, Epstein JI, Reinhard CS, Chasin M, Brem H (1989) J Biomed Mater Res 23:253

    Article  CAS  Google Scholar 

  251. Albertsson A-C, Lundmark S (1988) J Macromol Sci Chem A 25:247

    Article  Google Scholar 

  252. Albertsson A-C, Lundmark S (1990) Br Polym J 23:205

    Article  CAS  Google Scholar 

  253. Domb AJ, Amselem S, Shah J, Maniar M (1993) Adv Polym Sci 107:94

    Google Scholar 

  254. Domb AJ, Langer R (1987) J Polym Sci A Polym Chem 25:3373

    Article  CAS  Google Scholar 

  255. Albertsson A-C, Lundmark S (1990) J Macromol Sci Chem A 27:397

    Google Scholar 

  256. Lundmark S, Sjöling M, Albertsson A-C (1991) J Macromol Sci Chem A 28:15

    Article  Google Scholar 

  257. Albertsson A-C, Eklund M (1995) J Appl Polym Sci 57:87

    Article  CAS  Google Scholar 

  258. Shieh L, Tamada J, Chen I, Pang J, Domb A, Langer R (1994) J Biomed Mater Res 28:1465

    Article  CAS  Google Scholar 

  259. Mathiowitz E, Ron E, Mathiowitz G, Amato C, Langer R (1990) Macromolecules 23:3212

    Article  CAS  Google Scholar 

  260. Göpferich A, Langer R (1993) J Polym Sci A Polym Chem 31:2445

    Article  Google Scholar 

  261. Shuai X, Tan H, Jedlinski Z (1997) Polym Bull 39:21

    Article  CAS  Google Scholar 

  262. Teomim D, Nyska A, Domb AJ (1999) J Biomed Mater Res 45, 258

    Article  CAS  Google Scholar 

  263. Gouin S, Zhu XX, Lehnert S (2000) Macromolecules 33:5379

    Article  CAS  Google Scholar 

  264. Uhrich KE, Gupta A, Thomas TT, Laurencin CT, Langer R (1995) Macromolecules 28:2184

    Article  CAS  Google Scholar 

  265. Chiba M, Hanes J, Langer R (1997) Biomaterials 18:893

    Article  CAS  Google Scholar 

  266. Jiang HL, Zhu KJ (1999) Polym Int 48:47

    Article  CAS  Google Scholar 

  267. Albertsson A-C, Carlfors J, Sturesson C (1996) J Appl Polym Sci 62:695

    Article  CAS  Google Scholar 

  268. Dang W, Daviau T, Brem H (1996) Pharm Res 13:683

    Article  CAS  Google Scholar 

  269. Mayberg MR, Gross AS, Mathiowitz E, Langer R (1992) Polym Adv Technol 3:331

    Article  CAS  Google Scholar 

  270. Teomim D, Fishbien I, Golomb G, Orloff L, Mayberg M, Domb AJ (1999) J Control Rel 60:129

    Article  CAS  Google Scholar 

  271. Stephens D, Li L, Robinson D, Chen S, Chang H-C, Liu RM, Tian Y, Ginsburg EJ, Gao X, Stultz T (2000) J Control Rel 63:305

    Article  CAS  Google Scholar 

  272. Erdmann L, Uhrich KE (2000) Biomaterials 21:1941

    Article  CAS  Google Scholar 

  273. Carothers WH, van Natta FJ (1930) J Am Chem Soc 52:314

    Article  CAS  Google Scholar 

  274. Kricheldorf HR, Jenssen J (1989) J Macromol Sci Chem A 26:631

    Article  Google Scholar 

  275. Kricheldorf HR, Dunsing R, Serra I, Albet A (1987) Makromol Chem 188:2453

    Article  CAS  Google Scholar 

  276. Matsumura S, Tsukada K, Toshima K (1997) Macromolecules 30:3122

    Article  CAS  Google Scholar 

  277. Bisht KS, Svirkin YY, Henderson LA, Gross RA, Kaplan DL, Swift G (1997) Macromolecules 30:7735

    Article  CAS  Google Scholar 

  278. Ranucci E, Liu Y, Lindblad MS, Albertsson A-C (2000) Macromol Rapid Comm 21:680

    Article  CAS  Google Scholar 

  279. Albertsson A-C, Sjöling M (1992) J Macromol Sci Pure Appl Chem A 29:43

    Article  Google Scholar 

  280. Albertsson A-C, Eklund M (1994) J Polym Sci A Polym Chem 32:265

    Article  CAS  Google Scholar 

  281. Hooper KA, Cox JD, Kohn J (1997) J Appl Polym Sci 63:1499

    Article  CAS  Google Scholar 

  282. McNeill IC, Rincon A (1989) Polym Degr Stab 24:59

    Article  CAS  Google Scholar 

  283. Buchholz B (1993) J Mater Sci Mater Med 4:381

    Article  CAS  Google Scholar 

  284. Joziasse CA, Grablowitz H, Pennings AJ (2000) Macromol Chem Phys 201:107

    Article  CAS  Google Scholar 

  285. Capozza RC (1978) US Patent 4,066,747

    Google Scholar 

  286. Choi NS, Heller J (1978) US Patent 4,079,038

    Google Scholar 

  287. Choi NS, Heller J (1978) US Patent 4,093,709

    Google Scholar 

  288. Choi NS, Heller J (1979) US Patent 4,138,344

    Google Scholar 

  289. Heller J (1990) Drugs Pharm Sci 45:121

    CAS  Google Scholar 

  290. Heller J, Helwing RF, Penhale DW (1981) US Patent 4,304,767

    Google Scholar 

  291. Heller J, Roskos KV, Duncan R (1993) Makromol Chem Macromol Symp 70/71:163

    Google Scholar 

  292. Merkli A, Heller J, Tabatabay C, Gurny R (1995) J Control Rel 33:415

    Article  CAS  Google Scholar 

  293. Albertsson A-C, Palmgren R (1993) J Macromol Sci Pure Appl Chem A 30:919

    Article  Google Scholar 

  294. Ray JA, Doddi N, Regula D, Williams JA, Melveger A (1981) SurgGynecol 153:497

    CAS  Google Scholar 

  295. Nishida H, Yamashita M, Nagashima M, Endo T, Tokiwa Y (2000) J Polym Sci A Polym Chem 38:1560

    Article  CAS  Google Scholar 

  296. Kafrawy A, Mattei FV, Shalaby SW (1984) US Patent 4,470,416

    Google Scholar 

  297. Kafrawy A, Shalaby SW (1986) J Bioact Compat Polym 1:431

    Article  CAS  Google Scholar 

  298. Mathisen T, Albertsson A-C (1989) Macromolecules 22:3838

    Article  CAS  Google Scholar 

  299. Löfgren A, Albertsson A-C, Dubois Ph, Jérôme R, Teyssié Ph (1994) Macromolecules 27:5556

    Article  Google Scholar 

  300. Stridsberg K, Albertsson A-C (1999) J Polym Sci A Polym Chem 37:3407

    Article  CAS  Google Scholar 

  301. Palmgren R, Karlsson S, Albertsson A-C (1997) J Polym Sci A Polym Chem 35:1635

    Article  CAS  Google Scholar 

  302. Karlsson S, Hakkarainen M, Albertsson A-C (1994) J Chromatogr A 688:251

    Article  CAS  Google Scholar 

  303. Stridsberg K, Albertsson A-C (2000) J Polym Sci A Polym Chem 38:1774

    Article  CAS  Google Scholar 

  304. Flinn JE,N ack H (1967) Chem Eng (New York) 75:171

    Google Scholar 

  305. Watts PJ, Davies MC, Melia CD (1990) Crit Rev Ther Drug Carrier Syst 7:235

    CAS  Google Scholar 

  306. Jain R, Shah NH, Malick AW, Rhodes CT (1998) Drug Dev Ind Pharm 24:703

    Article  CAS  Google Scholar 

  307. Arshady R (1991) J Control Rel 17:1

    Article  CAS  Google Scholar 

  308. Bakan JA (1975) Polym Sci Technol 8:213

    CAS  Google Scholar 

  309. Tice TR, Lewis DH (1983) US Patent 4,389,330

    Google Scholar 

  310. Viswanathan NB, Thomas PA, Pandit JK, Kulkarni MG, Mashelkar RA (1999) J Control Rel 58:9

    Article  CAS  Google Scholar 

  311. Nuwayser ES, Nucefora WA (1986) US Patent 4,623,588

    Google Scholar 

  312. Booth AF (2000) Sterilization validation and routine operation handbook. Technomic Publishing Company, Lancaster

    Google Scholar 

  313. Nair PD (1995) J Biomater Appl 10:121

    CAS  Google Scholar 

  314. Sintzel MB, Merkli, A, Tabatabay C, Gurny R (1997) Drug Dev Ind Pharm 23:857

    Article  CAS  Google Scholar 

  315. Bruck SD, Mueller EP (1988) J Biomed Mater Res (Appl Biomater) 22:133

    Article  CAS  Google Scholar 

  316. Burg KJL, Shalaby SW (1996) ACS Symp Ser Irradiation of Polymers 620:240

    CAS  Google Scholar 

  317. Birkinshaw C, Buggy M, Henn GG (1992) Polym Degr Stab 38:249

    Article  CAS  Google Scholar 

  318. Mäder K, Domb A, Swartz HM (1996) Appl Radiat Isot 47:1669

    Article  Google Scholar 

  319. Domb AJ, Langer R (1989) Macromolecules 22:2117

    Article  CAS  Google Scholar 

  320. Hyon S-H, Jamshidi K, Ikada Y (1998) Polym Int 46:196

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Polymer Technology, Royal Institute of Technology, 10044, Stockholm, Sweden

    U. Edlund & A. -C. Albertsson

Authors
  1. U. Edlund
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. -C. Albertsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Edlund, U., Albertsson, A.C. (2002). Degradable Polymer Microspheres for Controlled Drug Delivery. In: Degradable Aliphatic Polyesters. Advances in Polymer Science, vol 157. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45734-8_3

Download citation

  • DOI: https://doi.org/10.1007/3-540-45734-8_3

  • Received:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42249-5

  • Online ISBN: 978-3-540-45734-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation