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Chip Technology pp 21–42Cite as

High-Density GeneChip Oligonucleotide Probe Arrays

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 77))

Abstract

High-density DNA probe arrays provide a highly parallel approach to nucleic acid sequence analysis that is transforming gene-based biomedical research. Photolithographic DNA synthesis has enabled the large-scale production of GeneChip probe arrays containing hundreds of thousands of oligonucleotide sequences on a glass “chip” about 1.5 cm2 in size. The manufacturing process integrates solid-phase photochemical oligonucleotide synthesis with lithographic techniques similar to those used in the microelectronics industry. Due to their very high information content, GeneChip probe arrays are finding widespread use in the hybridization-based detection and analysis of mutations and polymorphisms (“genotyping”), and in a wide range of gene expression studies.

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Author information

Authors and Affiliations

  1. Affymetrix, Inc., 3380 Central Expressway, Santa Clara, CA, 95051, USA

    Glenn H. McGall

  2. Affymetrix, Inc., 3380 Central Expressway, Santa Clara, CA, 95051, USA

    Fred C. Christians

Authors
  1. Glenn H. McGall
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  2. Fred C. Christians
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Editor information

Editors and Affiliations

  1. Functional Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 506, 69120, Heidelberg, Germany

    Jörg Hoheisel

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© 2002 Springer-Verlag Berlin Heidelberg

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McGall, G.H., Christians, F.C. (2002). High-Density GeneChip Oligonucleotide Probe Arrays. In: Hoheisel, J., et al. Chip Technology. Advances in Biochemical Engineering/Biotechnology, vol 77. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45713-5_2

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  • DOI: https://doi.org/10.1007/3-540-45713-5_2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43215-9

  • Online ISBN: 978-3-540-45713-8

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