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Evolutionary perspectives on protein structure, stability, and functionality

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Biological Evolution and Statistical Physics

Part of the book series: Lecture Notes in Physics ((LNP,volume 585))

Abstract

Proteins are the result of a long process of evolution. It is due to this process that they have developed properties rather different from those of random strings of amino acids. If we wish to understand the properties of proteins, we need to understand the underlying process of Darwinian evolution, and how its stochastic nature interacts with the underlying fitness landscape. In this review, I describe some of the underlying theory of evolution. I then discuss how these theories can help us understand the structure, thermodynamics, and functioning of naturally-occurring proteins.

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Authors and Affiliations

  1. Biophysics Research Division and Department of Chemistry, University of Michigan, 48109-1055, Ann Arbor, MI

    Richard A. Goldstein

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  1. Richard A. Goldstein
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Editors and Affiliations

  1. Institute for Theoretical Physics, University of Cologne, Zülpicher Straße 77, 50937, Köln, Germany

    Michael Lässig

  2. Theory Division, MPI for Colloids and Interfaces, 14424, Potsdam, Germany

    Angelo Valleriani

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Goldstein, R.A. (2002). Evolutionary perspectives on protein structure, stability, and functionality. In: Lässig, M., Valleriani, A. (eds) Biological Evolution and Statistical Physics. Lecture Notes in Physics, vol 585. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45692-9_5

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  • DOI: https://doi.org/10.1007/3-540-45692-9_5

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