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Aluminofluoride Complexes in the Etiology of Alzheimer’s Disease

  • Anna Strunecká
  • Jiri Patočka
Chapter
Part of the Structure and Bonding book series (STRUCTURE, volume 104)

Abstract

The question of aluminum’s relevance to the etiology of Alzheimer’s disease cannot yet be adequately answered. The mechanisms of how aluminum could evoke the hallmarks of AD are not known. Reflecting many studies, which utilize aluminofluoride complexes in laboratory investigations, we suggest that these complexes may act as the initial signal stimulating impairment of homeostasis, degeneration, and death of the cells. Aluminum ions in the presence of fluoride can accelerate the aging and impair the functions of the nervous system. In respect to the etiology of Alzheimer’s disease, the long-term synergistic action of aluminum ions and fluorides may represent a hidden but serious and powerful risk factor for the development of this devastating threat to human civilization.

Keywords

Alzheimer’s disease Aluminum Fluoride Aluminofluoride complexes G-protein 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Anna Strunecká
    • 1
  • Jiri Patočka
    • 2
  1. 1.Faculty of Science, Department of Physiology and Developmental PhysiologyCharles University PraguePrague 2Czech Republic
  2. 2.Department of ToxicologyMilitary Medical AcademyHradec KraloveCzech Republic

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