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Aluminum: Interaction with Nucleotides and Nucleotidases and Analytical Aspects of Its Determination

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Group 13 Chemistry II

Part of the book series: Structure and Bonding ((STRUCTURE,volume 104))

Abstract

Aluminum is known to affect a wide variety of biological systems. The evolution of life in a highly aluminum-rich biosphere did not result in a known physiological role of aluminum, which is considered a non-essential trace element of low toxicity in living being. In this chapter we review some toxicological and biological aspects of aluminum, as well as the interaction of this element with enzymes that use nucleotides in their reactions. It is assumed that phosphate-bearing biomolecules are elected targets for the biochemical action for aluminum. There is a large number of proteins which require nucleoside phosphates as substrates or are regulated by them. The toxicological mechanisms of aluminum in plants or animals probably involve alterations in the activity of such proteins. As examples of enzymes focus will be placed on NTPases, NTPDases, and kinases. As aluminum in biological systems occurs at trace levels, the analysis of biological matrices will be outlined with respect to aluminum determination considering contamination sources, sample collection and preparation, and methodological procedures.

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Authors and Affiliations

  1. Departamento de Química, CCNE, Universidade Federal de Santa Maria, RS, Brazil, 97105 900

    Maria Rosa Chitolina Schetinger, Vera Maria Morsch & Denise Bohrer

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  1. Maria Rosa Chitolina Schetinger
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  2. Vera Maria Morsch
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  3. Denise Bohrer
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Editors and Affiliations

  1. Institut für Anorganische Chemie der Universität Göttingen, Tammannstr. 4, 37077, Göttingen, Germany

    Herbert W. Roesky

  2. Department of Chemistry, University of Kentucky, Lexington, Kentucky, 40506 0055, USA

    David A. Atwood

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Schetinger, M.R.C., Morsch, V.M., Bohrer, D. (2002). Aluminum: Interaction with Nucleotides and Nucleotidases and Analytical Aspects of Its Determination. In: Roesky, H.W., Atwood, D.A. (eds) Group 13 Chemistry II. Structure and Bonding, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45425-X_4

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