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Plant Cells pp 103–125Cite as

Genetic Modification of Plant Secondary Metabolite Pathways Using Transcriptional Regulators

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 72))

Abstract

Plant secondary metabolism is the source of many natural products with diverse applications, including pharmaceuticals, food colors, dyes and fragrances. Functions in plants include attraction of pollinating insects and protection against pests and pathogens. An important regulatory step in secondary metabolism is transcription of the biosynthetic genes. The aim of this chapter is to discuss results and opportunities concerning modification of secondary metabolism using transcriptional regulators. The transcriptional regulation of two well-studied secondary pathways, the phenylpropanoid pathway and its flavonoid branch, and the terpenoid indole alkaloid biosynthetic pathway, are reviewed. Some examples of successful engineering of these pathways via transcriptional regulators are discussed.

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Authors and Affiliations

  1. Institute of Molecular Plant Sciences, Clusius Laboratory, Wassenaarseweg 64, 2333 AL, Leiden, The Netherlands

    Johan Memelink & Jan W. Kijne

  2. Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Leiden University, PO Box 9502, 2300 RA, Leiden, The Netherlands

    Robert van der Heijden & Rob Verpoorte

Authors
  1. Jan W. Kijne
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  2. Robert van der Heijden
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  3. Rob Verpoorte
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Editors and Affiliations

  1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

    J. -J. Zhong

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© 2001 Springer-Verlag Berlin Heidelberg

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Memelink, J., Kijne, J.W., van der Heijden, R., Verpoorte, R. (2001). Genetic Modification of Plant Secondary Metabolite Pathways Using Transcriptional Regulators. In: Zhong, J.J., et al. Plant Cells. Advances in Biochemical Engineering/Biotechnology, vol 72. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45302-4_4

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  • DOI: https://doi.org/10.1007/3-540-45302-4_4

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