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Metabolic Engineering of Saccharomyces cerevisiae for Xylose Utilization

  • Bärbel Hahn-Hägerdal
  • C. Fredrik Wahlbom
  • Márk Gárdonyi
  • Willem H. van Zyl
  • Ricardo R. Cordero Otero
  • Leif J. Jönsson
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 73)

Abstract

Metabolic engineering of Saccharomyces cerevisiae for ethanolic fermentation of xylose is summarized with emphasis on progress made during the last decade. Advances in xylose transport, initial xylose metabolism, selection of host strains, transformation and classical breeding techniques applied to industrial polyploid strains as well as modeling of xylose metabolism are discussed. The production and composition of the substrates — lignocellulosic hydrolysates — is briefly summarized. In a future outlook iterative strategies involving the techniques of classical breeding, quantitative physiology, proteomics, DNA micro arrays, and genetic engineering are proposed for the development of efficient xylose-fermenting recombinant strains of S. cerevisiae.

Keywords

Xylose Saccharomyces cerevisiae Ethanol Lignocellulose Metabolic engineering 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Bärbel Hahn-Hägerdal
    • 1
  • C. Fredrik Wahlbom
    • 1
  • Márk Gárdonyi
    • 1
  • Willem H. van Zyl
    • 2
  • Ricardo R. Cordero Otero
    • 2
  • Leif J. Jönsson
    • 1
  1. 1.Department of Applied MicrobiologyLund UniversityLundSweden
  2. 2.Department of MicrobiologyUniversity of StellenboschStellenboschSouth Africa

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