Abstract
Modeling of mechanisms involved in electrophysiology and tension development of cardiac myocytes can enhance the understanding of physiological and pathophysiological cardiac phenomena. Interactions of divers components are necessary for cellular electro-mechanics. Particularly, the interactions between proteins in the cell membrane, sarcoplasmic reticulum and sarcomere are of importance. In this work hybrid electro-mechanical models of cardiac myocytes were derived on basis of recently developed models as well as of measurements ranging from protein to multi-cell level. The models quantify dynamically the electrophysiology and tension development by states, partly associated to configurations of the involved proteins, and the transition between these states. The models allow the reconstruction of electro-mechanical phenomena. Results of simulations with the hybrid models were performed illustrating their properties. The models may help to clarify feedback and cooperativity mechanisms, pathophysiological changes and metabolism of myocytes.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bers, D.M.: Cardiac excitation-contraction coupling. Nature 415 (2002) 198–205
Sachse, F.B.: Modeling of the mammalian heart, Universität Karlsruhe (TH), Institut für Biomedizinische Technik (2002) Habilitationsschrift.
Noble, D., Varghese, A., Kohl, P., Noble, P.: Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length-and tension-dependend processes. Can. J. Cardiol. 14 (1998) 123–134
Noble, P.:-. personal communication (2000)
Hill, A.V.: The heat of shortening and the dynamic constants of muscle. Proc. R. Soc. Lond. B126 (1938) 136–195
Fabiato, A., Fabiato, F.: Contractions induced by a calcium-triggered release of calcium for the sarcoplasmic reticulum of single skinned cardiac cells. J. Physiol. Lond. 249 (1975) 469–495
de Clerck, N.M., Claes, V.A., Brutsaert, D.L.: Force velocity relations of single cardiac muscle cells. J. Gen. Physiol. 69 (1977) 221–241
Bers, D.M.: Excitation-Contraction Coupling and Cardiac Contractile Force. Kluwer Academic Publishers, Dordrecht, Netherlands (1991)
White, E., Guennec, J.Y.L., Nigretto, J.M., Gannier, F., Argibay, J.A., Garnier, D.: The effects of increasing cell length on auxotonic contractions; membrane potential and intracellular calcium transients in single guinea-pig ventricular myocytes. Experimental Physiol. (1993) 65–78
Gannier, F., Bernengo, J.C., Jacquemond, V., Garnier, D.: Measurements of sarcomere dynamics simultaneously with auxotonic force in isolated cardiac cells. IEEE Transactions on Biomedical Engineering 40 (1993) 1226–1232
White, E., Boyett, M.R., Orchard, C.H.: The effects of mechanical loading and changes to length on single guinea-pig ventricular myocytes. J. Physiol. (1995) 93–107
Bluhm, W.F., McCulloch, A.D., Lew, W.Y.W.: Active force in rabbit ventricular myocytes. J. Biomechanics 28 (1995) 1119–1122
Brandt, P.W., Colomo, F., Piroddi, N., Poggesi, C., Tesi, C.: Force regulation by Ca2+ in skinned single cardiac myocytes of frog. Biophys J 74 (1998) 1994–2004
O’Rourke, B., Kass, D.A., Tomaselli, G.F., Kaab, S., Tunin, R., Marbán, E.: Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I experimental studies. Circ. Res 84(5) (1999) 562–570
Yasuda, S., Sugiura, S., Kobayakawa, N., Fjita, H., Yamashita, H., Katoh, K., Seaki, Y., Kaneko, H., Suda, Y., Nagai, R., Sugi, H.: A novel method to study contraction characteristics of a single cardiac myocyte using carbon fibers. Am. J. Physiol. 281 (2001) H1442–H1446
Irving, M., Goldman, Y.E.: Another step ahead for myosin. Nature 398 (1999) 463–465
Kitamura, K., Tokunaga, M., Iwane, A.H., Yanagida, T.: A single myosin head moves along an actin filament with regular steps of 5.3 nanometeres. Nature 397 (1999) 129–134
Lodish, H., Berk, A., Zipursky, S.L., Matsudaira, P., Baltimore, D., Darneell, J.: Molekulare Zellbiologie. Spektrum Akademischer Verlag, Heidelberg, Berlin (2001)
Allen, D., Kurihara, S.: The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. J. Physiol. 327 (1982) 79–94
Nagashima, H., Asakura, S.: Studies on co-operative properties of tropomyosin-actin and tropomyosin-troponin-actin complexes by use of N-ethylmaleinide-treated and untreated species of myosin subfragment. J. Mol. Bio. 155 (1982) 409–428
Tobacman, L.: Thin filament mediated regulation of cardiac contraction. Ann. Rev. Physiol. 58 (1996) 447–481
Spudich, J.A.: TIMELINE: The myosin swinging cross-bridge model. Nature Reviews Molecular Cell Biology 2 (2001) 387–392
Glänzel, K.: Kraftentwicklung im Sarkomer unter Berücksichtigung elektromechanischer Kopplung. Diploma Thesis, Institut für Biomedizinische Technik, Universität Karlsruhe (TH) (2002)
Rice, J.J., Winslow, R.L., Hunter, W.C.: Comparison of putative cooperative mechanisms in cardiac muscle: length dependence and dynamic responses. Am. J. Physiol. Circ. Heart. 276 (1999) H1734–H1754
Gordon, A., Regnier, M., Homsher, E.: Skeletal and cardiac muscle contractile activation: Tropomyosin “rocks and rolls”. News Physiol. Sci. 16 (2001) 49–55
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sachse, F.B., Glänzel, K., Seemann, G. (2003). Modeling of Electro-mechanical Coupling in Cardiac Myocytes: Feedback Mechanisms and Cooperativity. In: Magnin, I.E., Montagnat, J., Clarysse, P., Nenonen, J., Katila, T. (eds) Functional Imaging and Modeling of the Heart. FIMH 2003. Lecture Notes in Computer Science, vol 2674. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44883-7_7
Download citation
DOI: https://doi.org/10.1007/3-540-44883-7_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-40262-6
Online ISBN: 978-3-540-44883-9
eBook Packages: Springer Book Archive