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Why Ischemic Hearts Respond Less to Cardiac Resynchronisation Therapy. A Modeling Study

  • Piet Claus
  • Bart Bijnens
  • Ole-Alexander Breithardt
  • George R. Sutherland
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2674)

Abstract

Cardiac Resynchronisation Therapy (CRT) by means of simultaneous biventricular or multisite leftventricular pacing is a new technique for improving left ventricular systolic performance in patients with heart failure and conduction abnormalities (e.g. left bundle branch block). However, different pathological cases do react differently to CRT and the underlying mechanisms are poorly understood. This paper presents a study of the mechanical effects of delayed activation on ejection and regional deformation using a simplified mathematical model. These effects are studied in normal and dilated hearts, and ischemic non-dilated and dilated hearts. From these simulations we derive dependencies of regional performance parameters on delayed activation and discuss why ischemic hearts do respond less to CRT.

Keywords

Cardiac Resynchronisation Therapy Biventricular Pace Delayed Activation Ischemic Simulation Ischemic Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Piet Claus
    • 1
  • Bart Bijnens
    • 1
  • Ole-Alexander Breithardt
    • 2
  • George R. Sutherland
    • 1
  1. 1.Department of CardiologyK.U.Leuven, University Hospitals GasthuisbergLeuvenBelgium
  2. 2.Department of CardiologyUniversity Hospital AachenAachenGermany

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