Left Ventricular Flow Dynamics and Transmural Gradients in Myofiber Shortening with MRI-Tagging

  • T. Arts
  • T. Delhaas
  • A. van Susteren
  • G. Snoep
  • F. W. Prinzen
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2674)


Most cardiac diseases are related to non-uniformities in contractile function. Such regional non- uniformities can be recognized conventionally, but transmural gradients in mechanical function cannot be determined that easily. We propose a method to assess transmural differences in myofiber shortening, using MRI- tagging of the heart. Midwall motion of 5 short-axis slices of the left ventricle was determined non-invasively. Using a model of cardiac motion, the transmural distribution of deformation of the left ventricular wall was determined. On the basis of remodeling rules, the transmural course of myofiber orientation was estimated. From deformation and fiber orientation data transmural differences in myofiber shortening were calculated. The method appears sensitive to distinguish patients with aortic stenosis from healthy volunteers.


Aortic Stenosis Aortic Valve Stenosis Helix Angle Wall Area Transmural Gradient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • T. Arts
    • 1
  • T. Delhaas
    • 2
  • A. van Susteren
    • 1
  • G. Snoep
    • 3
  • F. W. Prinzen
    • 2
  1. 1.Departments of Biophysics, Cardiovascular Research InstituteMaastricht UniversityMaastrichtThe Netherlands
  2. 2.Departments of Physiology, Cardiovascular Research InstituteMaastricht UniversityMaastrichtThe Netherlands
  3. 3.Department of RadiologyAcademic Hospital MaastrichtMaastrichtThe Netherlands

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