Left Ventricular Flow Dynamics and Transmural Gradients in Myofiber Shortening with MRI-Tagging
Most cardiac diseases are related to non-uniformities in contractile function. Such regional non- uniformities can be recognized conventionally, but transmural gradients in mechanical function cannot be determined that easily. We propose a method to assess transmural differences in myofiber shortening, using MRI- tagging of the heart. Midwall motion of 5 short-axis slices of the left ventricle was determined non-invasively. Using a model of cardiac motion, the transmural distribution of deformation of the left ventricular wall was determined. On the basis of remodeling rules, the transmural course of myofiber orientation was estimated. From deformation and fiber orientation data transmural differences in myofiber shortening were calculated. The method appears sensitive to distinguish patients with aortic stenosis from healthy volunteers.
KeywordsAortic Stenosis Aortic Valve Stenosis Helix Angle Wall Area Transmural Gradient
Unable to display preview. Download preview PDF.
- 1.Axel, L. and L. Dougherty. MR imaging of motion with spatial modulation of magnetization. Radiology, 1989. 171: 841–845.Google Scholar
- 2.Tseng, W.Y., T.G. Reese, R.M. Weisskoff, T.J. Brady, and V.J. Wedeen. Myocardial fiber shortening in humans: initial results of MR imaging. Radiology, 2000. 216: 128–39.Google Scholar
- 6.Geerts, L., P. Bovendeerd, K. Nicolay, and T. Arts. Characterization of the normal cardiac myofiber field in goat measured with MR Diffusion Tensor Imaging. Am J Physiol, 2002. 283: H139–H145.Google Scholar
- 7.Arts, T., P.H.M. Bovendeerd, F.W. Prinzen, and R.S. Reneman. Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys J, 1991. 59: 93–103.Google Scholar
- 9.Streeter, D.D. Gross morphology and fiber geometry of the heart, in the cardiovascular system, the heart, R.M. Berne, Editor. 1979, Am Physiol Soc: Bethesda, Maryland, USA. 61–112.Google Scholar
- 10.Van der Toorn, A., P. Barenbrug, G. Snoep, F.H. Van der Veen, T. Delhaas, F.W. Prinzen, and T. Arts. Transmural gradients of cardiac myofiber shortening in aortic valve stenosis patients using MRI-tagging. Am J Physiol, 2002. 283: H1609–1615.Google Scholar