First 36-Channel Magnetocardiographic Study of CAD Patients in an Unshielded Laboratory for Interventional and Intensive Cardiac Care

  • Donatella Brisinda
  • Anna Maria Meloni
  • Riccardo Fenici
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2674)


The first 36-channel Magnetocardiographic (MCG) system, successfully installed in the Biomagnetism Research Center, Catholic University of Rome, has been tested to evaluate the reliability of this novel instrumentation for the study of patients with coronary artery disease (CAD), in an “unshielded” laboratory for interventional and emergency cardiac care. 13 patients, with coronary disease documented by angiography, 8 patients with abnormality of non-invasive studies (exercise-ECG or SPECT), and 13 healthy controls (agematched) were investigated at rest. Other 6 cases were investigated, before and after stress test with a standard ergometer. The sensitivity of the system was 20 fT/√Hz, at 1Hz. After morphological evaluation, quantitative analysis of magnetocardiographic repolarization parameters was performed according to Hänninen et al. and Park et al. At rest, magnetocardiographic mapping has shown abnormality of repolarization in 95.2% of CAD patients, with sensibility of 92.6%, specificity of 92.3%, and predictive value 92.3%.


Coronary Artery Disease Patient Magnetic Field Distribution Ventricular Repolarization Inferior Myocardial Infarction Magnetic Field Orientation 
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  1. 1.
    Brockmeier, K., Schmitz, L., Bobadilla Chavez, J.D., Burghoff, M., Koch, H., Zimmermann, R., Trahms, L.: Magnetocardiography and 32-lead potential mapping: repolarization in normal subjects during pharmacologically induced stress. J Cardiovasc Electrophysiol. 18 (1997) 615–626CrossRefGoogle Scholar
  2. 2.
    Nomura, M., Nakaya, Y., Fujino, K., Ishihara, S., Katayama, M., Takeuchi, A., Watanabe, K., Hiasay, Y., Aihara, T., Mori, H.: Magnetocardiographic studies of ventricular repolarization in old inferior myocardial infarction. Eur Heart J. 10(1) (1989) 8–15Google Scholar
  3. 3.
    Sato, M., Terada, Y., Mitsui, T., Miyashita, T., Kandori, A., Tsukada, K.: Detection of myocardial ischemia by magnetocardiogram using 64-channel SQUID system. In: Nenonen, J., Ilmoniemi, R.J., Katila, T., (eds): Proceedings 12th International Conference on Biomagnetism, Helsinki Univ. of Technology, Espoo, Finland (2001) 523–526Google Scholar
  4. 4.
    Tsukada, K., Miyashita, T., Kandori, A., Mitsui, T., Terada, Y., Sato, M., Shiono, J., Horigone, H., Yamada, S., Yamaguchi, I.: An iso-integral mapping technique using magnetocardiogram and its possible use for diagnosis of ischemic heart disease. Int J Card Imaging 16(1) (2000) 55–66CrossRefGoogle Scholar
  5. 5.
    Hänninen, H., Takala, P., Mäkijärvi, M., Montonen, J., Korhonen, P., Oikarinen, L., Nenonen, J., Katila, T., Toivonen, L.: Detection of exercise induced myocardial ischemia by multichannel magnetocardiography in patients with single vessel coronary artery disease. Ann. Noninv Electrocardiology 5(2) (2000) 147–157CrossRefGoogle Scholar
  6. 6.
    Takala, P., Hänninen, H., Montonen, J., Makjiarvi, M., Nenonen, J., Oikarinen, L., Simeliu, K., Toivonen, L., Katila, T.: Magnetocardiographic and Electrocardiographic Exercise Mapping in Healthy Subjects. Annals of Biomedical Engineering 29 (2001) 501–509CrossRefGoogle Scholar
  7. 7.
    Brockmeier, K., van Leeuwen, P.: Magnetocardiographic stress test investigations analyzing ventricular repolarization changes. In: Nenonen, J., Ilmoniemim R.J., Katila, T., (eds.): Proceedings 12th International Conference on Biomagnetism, Helsinki Univ. of Technology, Espoo, Finland (2001) 546–548Google Scholar
  8. 8.
    Brazdeikis, A., Taylor, A. A., Mahmarian, J. J., Xue, Y., Chu, C.W. Comparison of magnetocardiograms acquired in unshielded clinical environment at rest, during and after exercise and in conjunction with myocardial perfusion imaging. In: Nowak, H., Haueisen, J., Giessler, F., Huonker, R., (eds): Proceedings 13th International Conference on Biomagnetism, Jena. VDE Verlag (2002) 530–532Google Scholar
  9. 9.
    Leder, U., Novak, H., Haueisen, J.: Myocardial ischemia and viability. In: Nenonen, J., Ilmoniemi, R.J., Katila, T., (eds): Proceedings 12th International Conference on Biomagnetism, Helsinki Univ. of Technology, Espoo, Finland (2001) 518–522Google Scholar
  10. 10.
    Pesola, K., Hänninen, H., Lauerma, K.: Current density estimation on left ventricular epicardium: a potential method for ischemia localization. Biomed Tech. 44 (1999) 143–146CrossRefGoogle Scholar
  11. 11.
    Leder, U., Pohl, H.P., Michaelsen, S., Fritschi, T., Huch, M., Eichhom, J., Muller, S., Nowak, H.: Noninvasive biomagnetic imaging in coronary artery disease based on individual current density maps of the heart. Int J Cardiol. 13 (1998) 83–92CrossRefGoogle Scholar
  12. 12.
    Leder,U., Haueisen, J., Huck, M., Nowak, H.: Non-invasive imaging of arrhythmogenic left-ventricular myocardium after infarction. Lancet 352 (1998) 1825CrossRefGoogle Scholar
  13. 13.
    Park, J.W., Reichert, U., Malek, A., Klabes, M., Schafer, J., Jung, F.: Sensitivity and predictivity of Magnetocardiography for the Diagnosis of Ischemic Hearth Disease in Patients with Acute Chest Pain: Preliminary Results of the Hoyerswerda Registry Study” (personal communication)Google Scholar
  14. 14.
    Wikswo, J.P., Barach, J.P.: Possible sources of new information in the magnetocardiogram. Journal of Theoretical Biology 95 (1982) 721–729CrossRefGoogle Scholar
  15. 15.
    Cohen, D., Kaufman, L.A.: Magnetic determination of the relationship between the ST segment shift and the injury current produced by coronary artery occlusion. Circ. Res. 36 (1975) 414–424Google Scholar
  16. 16.
    Janse, M.J., Moreina, H., Cinca, J.: Role of re-entry and currents of injury in early ischemic ventricular tachyarrhythmias: which properties should theoretically make a drug effective in the management of these arrhythmias? In: Sandoe, E., Julian, D.G., Bekll, J.W. (eds): Management of ventricular tachycardia-role of mexiletine. Excerpat Medica (1978) 183–196Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Donatella Brisinda
    • 1
  • Anna Maria Meloni
    • 1
  • Riccardo Fenici
    • 1
  1. 1.Clinical Physiology - Biomagnetism Research CenterCatholic University of Sacred HeartRomeItaly

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