Nomenclature
EC number
2.1.2.8
Systematic name
5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase
Recommended name
deoxycytidylate 5-hydroxymethyltransferase
Synonyms
CH
d-cytidine 5′-monophosphate hydroxymethylase
dCMP Hmase
dCMP hydroxymethylase
deoxyCMP hydroxymethylase
deoxycytidylate hydroxymethylase
deoxycytidylate hydroxymethyltransferase
deoxycytidylic hydroxymethylase
hydroxymethyltransferase, deoxycytidylate
CAS registry number
9012-68-4
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References
Mathews, C.K.; Brown, R; Cohen, S.S.: Virus-induced acquisition of metabolic function. VII. Biosynthesis de novo of deoxycytidylate hydroxymethylase. J. Biol. Chem., 239, 2957–2963 (1964)
Pizer, L.I.; Cohen, S.S.: Virus-induced acquisition of metabolic function. V. Purification and properties of deoxycytidylate hydroxymethylase and studies on its origin. J. Biol. Chem., 237, 1251–1259 (1962)
Lamm, N.; Tomaschewski, J.; Ruger, W.: Nucleotide sequence of the deoxycytidylate hydroxymethylase gene of bacteriophage T4 (g42) and the homology of its gene product with thymidylate synthase of E. coli. Nucleic Acids Res., 15, 3920 (1987)
Lamm, N.; Wang, Y.; Mathews, C.K.; Ruger, W.: Deoxycytidylate hydroxymethylase gene of bacteriophage T4. Nucleotide sequence determination and over-expression of the gene. Eur. J. Biochem., 172, 553–563 (1988)
Allen, J.R.; Lasser, G.W.; Goldman, D.A.; Booth, J.W.; Mathews, C.K.: T4 phage deoxyribonucleotide-synthesizing enzyme complex. Further studies on enzyme composition and regulation. J. Biol. Chem., 258, 5746–5753 (1983)
Lee, M.H.; Gautam-Basak, M.; Wooley, C; Sander, E.G.: Deoxycytidylate hydroxymethylase: purification, properties, and the role of a thiol group in catalysis. Biochemistry, 27, 1367–1373 (1988)
North, T.W.; Mathews, C.K.: T4 phage-coded deoxycytidylate hydroxymethylase: purification and studies on intermolecular interactions. Biochem. Biophys. Res. Commun., 77, 898–904 (1977)
Subramaniam, R.; Wang, Y.; Mathews, C.K.; Santi, D.V.: On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2-deoxycytidine 5-mono-phosphate. Arch. Biochem. Biophys., 275, 11–15 (1989)
Mathews, C.K.; Wheeler, L.J.; Ungermann, C; Young, J.P.; Ray, N.B.: Enzyme interactions involving T4 phage-coded thymidylate synthase and deoxycytidylate hydroxymethylase. Adv. Exp. Med. Biol., 338, 563–570 (1993)
Graves, K.L.; Hardy, L.W.: Kinetic and equilibrium α-secondary tritium isotope effects on reactions catalyzed by dCMP hydroxymethylase from bacteriophage T4. Biochemistry, 33, 13049–13056 (1994)
Butler, M.M.; Graves, K.L.; Hardy, L.W.: Evidence from 18O exchange studies for an exocyclic methylene intermediate in the reaction catalyzed by T4 deoxycytidylate hydroxymethylase. Biochemistry, 33, 10521–10526 (1994)
Hardy, L.W.; Graves, K.L.; Nalivaika, E.: Electrostatic guidance of catalysis by a conserved glutamic acid in Escherichia coli dTMP synthase and bac-teriophage T4 dCMP hydroxymethylase. Biochemistry, 34, 8422–8432 (1995)
Song, H.K.; Sohn, S.H.; Suh, S.W.: Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonu-cleoside triphosphate-synthesizing complex. EMBO J., 18, 1104–1113 (1999)
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(2006). Deoxycytidylate 5-hydroxymethyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37716-6_8
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DOI: https://doi.org/10.1007/3-540-37716-6_8
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