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Acetyl-CoA C-acetyltransferase

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Springer Handbook of Enzymes

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 29))

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References

  1. Stern, J.R.; Drummond, G.I.; Coon, M.J.; Del Campillo, A.: Enzymes of ketone body metabolism. I. Purification of an acetoacetate-synthesizing enzyme from ox liver. J. Biol. Chem., 235, 313–317 (1960)

    PubMed  CAS  Google Scholar 

  2. Lynen, F.; Ochoa, S.: Enzymes of fatty acid metabolism. Biochim. Biophys. Acta, 12, 299–314 (1953)

    Article  PubMed  CAS  Google Scholar 

  3. Nishimura, T.; Saito, T.; Tomita, K.: Purification and properties of β-ketothiolase from Zoogloea ramigera. Arch. Microbiol., 116, 21–27 (1978)

    Article  PubMed  CAS  Google Scholar 

  4. Clinkenbeard, K.D.; Sugiyama, T.; Lane, M. D.: Cytosolic acetoacetyl-CoA thiolase from chicken liver. Methods Enzymol., 35 B, 167–173 (1975)

    Google Scholar 

  5. Holland, PC; Clark, M.G.; Bloxham, D. P.: Inactivation of pig heart thiolase by 3-butynoyl coenzyme A, 3-pentynoyl coenzyme A, and 4-bromocrotonyl coenzyme A. Biochemistry, 12, 3309–3315 (1973)

    Article  PubMed  CAS  Google Scholar 

  6. Clinkenbeard, K.D.; Sugiyama, T.; Moss, J.; Reed, W.D.; Lane, M.D.: Molecular and catalytic properties of cytosolic acetoacetyl coenzyme A thiolase from avian liver. J. Biol. Chem., 248, 2275–2284 (1973)

    PubMed  CAS  Google Scholar 

  7. Hartmanis, M.G.N.; Stadtman, T. C: Isolation of a selenium-containing thiolase from Clostridium kluyveri: identification of the selenium moiety as selenomethionine. Proc. Natl. Acad. Sci. USA, 79, 4912–4916 (1982)

    Article  PubMed  CAS  Google Scholar 

  8. Middleton, B.: The kinetic mechanism and properties of the cytoplasmic acetoacetyl-coenzyme A thiolase from rat liver. Biochem. J., 139, 109–121 (1974)

    PubMed  CAS  Google Scholar 

  9. Bloxham, D.P.; Chalkley, R.A.; Coghlin, S. J.; Salam, W.: Synthesis of chloromethyl ketone derivatives of fatty acids. Their use as specific inhibitors of acetoacetyl-coenzyme A thiolase, cholesterol biosynthesis and fatty acid synthesis. Biochem. J., 175, 999–1011 (1978)

    PubMed  CAS  Google Scholar 

  10. Huth, W.; Jonas, R.; Wunderlich, I.; Seubert, W.: On the mechanism of ketogenesis and its control. Purification, kinetic mechanism and regulation of different forms of mitochondrial acetoacetyl-CoA thiolases from ox liver. Eur. J. Biochem., 59, 475–489 (1975)

    Article  PubMed  CAS  Google Scholar 

  11. Schwabe, D.; Huth, W.: Immunochemical aspects, molecular and kinetic properties of multiple forms of acetyl-CoA acetyltransferase from rat liver mitochondria. Biochim. Biophys. Acta, 575, 112–120 (1979)

    PubMed  CAS  Google Scholar 

  12. Jonas, R.; Huth, W.: Acetyl-CoA acetyltransferase from bovine liver mitochondria. Molecular properties of multiple forms. Biochim. Biophys. Acta, 527, 379–390 (1978)

    PubMed  CAS  Google Scholar 

  13. Huth, W.; Dierich, C; von Oeynhausen, V.; Seubert, W.: Multiple mitochondrial forms of acetoacetyl-CoA thiolase in rat liver: possible regulatory role in ketogenesis. Biochem. Biophys. Res. Commun., 56, 1069–1077 (1974)

    Article  PubMed  CAS  Google Scholar 

  14. Olowe, Y.; Schulz, H.: Regulation of thiolases from pig heart. Control of fatty acid oxidation in heart. Eur. J. Biochem., 109, 425–429 (1980)

    Article  PubMed  CAS  Google Scholar 

  15. Davis, J.T.; Moore, R.N.; Imperiali, B.; Pratt, A.J.; Kobayashi, K.; Masamune, S.; Sinskey, A.J.; Walsh, C.T.; Fukui, T.; Tomita, K.: Biosynthetic thiolase from zoogloea ramigera. I. Preliminary characterization and analysis of proton transfer reaction. J. Biol. Chem., 262, 82–89 (1987)

    PubMed  CAS  Google Scholar 

  16. Davis, J.T.; Chen, H.H.; Moore, R.; Nishitani, Y.; Masamune, S.; Sinskey, A.J.; Walsh, C.T.: Biosynthetic thiolase from Zoogloea ramigera. II. Inactivation with haloacetyl CoA analogs. J. Biol. Chem., 262, 90–96 (1987)

    PubMed  CAS  Google Scholar 

  17. Peoples, O.P.; Masamune, S.; Walsh, S.T.; Sinskey, A.J.: Biosynthetic thiolase from Zoogloea ramigera. III. Isolation and characterization of the structural gene. J. Biol. Chem., 262, 97–102 (1987)

    PubMed  CAS  Google Scholar 

  18. Palmer, M.A.J.; Differding, E.; Gamboni, R.; Williams, S.F.; Peoples, O.P.; Walsh, C.T.; Sinskey, A.J.; Masamune, S.: Biosynthetic thiolase from Zoogloea ramigera. Evidence for a mechanism involving Cys-378 as the active site base. J. Biol. Chem., 266, 8369–8375 (1991)

    PubMed  CAS  Google Scholar 

  19. Wiesenborn, D.P.; Rudolph, F.B.; Papoutsakis, E.T.: Thiolase from Clostridium acetobutylicum ATCC 824 and its role in the synthesis of acids and solvents. Appl. Environ. Microbiol., 54, 2717–2722 (1988)

    PubMed  CAS  Google Scholar 

  20. Kurihara, T.; Ueda, M.; Tanaka, A.: Peroxisomal acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase from an n-alkane-utilizing yeast, Candida tropicalis: purification and characterization. J. Biochem., 106, 474–478 (1989)

    PubMed  CAS  Google Scholar 

  21. Sliwkowski, M.X.; Hartmanis, M.G.N.: Simultaneous single-step purification of thiolase and NADP-dependent 3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri. Anal. Biochem., 141, 344–347 (1984)

    Article  PubMed  CAS  Google Scholar 

  22. Suzuki, E; Zahler, W.L.; Emerich, D. W: Acetoacetyl-CoA thiolase of Bra-dyrhizobium japonicum bacteroids: purification and properties. Arch. Biochem. Biophys., 254, 272–281 (1987)

    Article  PubMed  CAS  Google Scholar 

  23. Greenspan, M.D.; Yudkovitz, J.B.; Chen, J.S.; Hanf, D.P.; Chang, M.N.; Chiang, P.Y.C.; Chabala, J.C.; Alberts, A.W.: The inhibition of cytoplasmic acetoacetyl-CoA thiolase by a triyne carbonate (L-660, 631). Biochem. Biophys. Res. Commun., 163, 548–553 (1989)

    Article  PubMed  CAS  Google Scholar 

  24. Feigenbaum, J.; Schulz, H.: Thiolases of Escherichia coli: purification and chain length specificities. J. Bacteriol., 122, 407–411 (1975)

    PubMed  CAS  Google Scholar 

  25. Duncombe, G.R.; Frerman, F.E.: Molecular and catalytic properties of the acetoacetyl-coenzyme A thiolase of Escherichia coli. Arch. Biochem. Biophys., 176, 159–170 (1976)

    Article  PubMed  CAS  Google Scholar 

  26. O’Connell, M.A.; Orr, G.; Shapiro, L.: Purification and characterization of fatty acid β-oxidation enzymes from Caulobacter crescentus. J. Bacteriol., 172, 997–1004 (1990)

    PubMed  CAS  Google Scholar 

  27. Anderson, V.E.; Bahnson, B.J.; Wlassics, I.D.: The reaction of acetyldithio-CoA, a readily enolized anaolg of acetyl-CoA with thiolase from Zoogloea ramigera. J. Biol. Chem., 266, 6255–6261 (1990)

    Google Scholar 

  28. Heijden, R.v.d.; Verpoorte, R.; Duine, J.A.: Biosynthesis of 3S-hydroxy-3-methylglutaryl-coenzyme A in Catharanthus roseus: Acetoacetyl-CoA thiolase and HMG-CoA synthase show similar chromatographic behavior. Plant Physiol. Biochem., 32, 807–812 (1994)

    CAS  Google Scholar 

  29. Kanayama, N.; Himeda, Y.; Atomi, H.; Ueda, M.; Tanaka, A.: Expression of acetoacetyl-CoA thiolase isoenzyme genes of n-alkane-assimilating yeast, Candida tropicalis: isoenzymes in two intracellular compartments are derived from the same genes. J. Biochem., 122, 616–621 (1997)

    PubMed  CAS  Google Scholar 

  30. Kim, S.A.; Copeland, L.: Acetyl coenzyme A acetyltransferase of Rhizobium sp. (Cicer) strain CC 1192. Appl. Environ. Microbiol., 63, 3432–3437 (1997)

    PubMed  CAS  Google Scholar 

  31. Kanayama, N.; Ueda, M.; Atomi, H.; Tanaka, A.: Genetic evaluation of physiological functions of thiolase isoenzymes in the n-alkane-assimilating yeast Candida tropicalis. J. Bacteriol., 180, 690–698 (1998)

    PubMed  CAS  Google Scholar 

  32. Honda, A.; Salen, G.; Nguyen, L.B.; Xu, G.; Tint, G.S.; Batta, A.K.; Shefer, S.: Regulation of early cholesterol biosynthesis in rat liver: effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities. Hepatology, 27, 154–159 (1998)

    Article  PubMed  CAS  Google Scholar 

  33. Modis, Y.; Wierenga, R.K.: A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism. Structure, 7, 1279–1290 (1999)

    Article  PubMed  CAS  Google Scholar 

  34. Antonenkov, V.D.; Croes, K.; Waelkens, E.; Van Veldhoven, P.P.; Mannaerts, G.P.: Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes. Eur. J. Biochem., 267, 2981–2990 (2000)

    Article  PubMed  CAS  Google Scholar 

  35. Lobo, S.; Florova, G.; Reynolds, K.A.: A Streptomyces collinus thiolase with novel acetyl-CoA:acyl carrier protein transacylase activity. Biochemistry, 40, 11955–11964 (2001)

    Article  PubMed  CAS  Google Scholar 

  36. Kursula, P.; Ojala, J.; Lambeir, A.M.; Wierenga, R.K.: The catalytic cycle of biosynthetic thiolase: a conformational journey of an acetyl group through four binding modes and two oxyanion holes. Biochemistry, 41, 15543–15556 (2002)

    Article  PubMed  CAS  Google Scholar 

  37. Hedl, M.; Sutherlin, A.; Wilding, E.I.; Mazzulla, M.; McDevitt, D.; Lane, P.; Burgner, J.W.; Lehnbeuter, K.R.; Stauffacher, C.V.; Gwynn, M.N.; Rodwell, V.W.: Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. J. Bacteriol., 184, 2116–2122 (2002)

    Article  PubMed  CAS  Google Scholar 

  38. Liu, T.; Liu, S.J.; Xue, Y.; Ma, Y.; Zhou, P.: Purification and characterization of an extremely halophilic acetoacetyl-CoA thiolase from a newly isolated Halobacterium strain ZP-6. Extremophiles, 6, 97–102 (2002)

    Article  PubMed  CAS  Google Scholar 

  39. Oeljeklaus, S.; Fischer, K.; Gerhardt, B.: Glyoxysomal acetoacetyl-CoA thiolase and 3-oxoacyl-CoA thiolase from sunflower cotyledons. Planta, 214, 597–607 (2002)

    Article  PubMed  CAS  Google Scholar 

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  1. Institute for Biochemistry, University to Cologne, Zülpicher Strasse 47, 50674, Cologne, Germany

    Dietmar Schomburg , Ida Schomburg  & Antje Chang ,  & 

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(2006). Acetyl-CoA C-acetyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37716-6_38

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