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Arylamine N-acetyltransferase

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Springer Handbook of Enzymes

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 29))

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References

  1. Fajardo, N.; Abreu, P.; Alonso, R.: Determination of kinetic properties of serotonin-N-acetyltransferase in bovine pineal gland using HPLC with fluorimetric detection. J. Pineal Res., 13, 80–84 (1992)

    Article  PubMed  CAS  Google Scholar 

  2. Grant, D.M.; Blum, M.; Beer, M.; Meyer, U.A.: Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes. Mol. Pharmacol., 39, 184–191 (1991)

    PubMed  CAS  Google Scholar 

  3. Ohtomi, M.; Tomoyuki, I.; Deguchi, T.: Arylamine N-acetyltransferase from the chicken kidney: characterization of the enzyme and localization of the mRNA by in situ hybridization. Biomed. Res., 11, 263–267 (1990)

    CAS  Google Scholar 

  4. Watson, A.P.; Wang, P.D.; Sim, E.: Arylamine N-acetyltransferase from fast (C57BL6) and slow (A/J) N-acetylating strains of mice. Biochem. Pharmacol., 39, 647–654 (1990)

    Article  PubMed  CAS  Google Scholar 

  5. Rodriguez-Cabello, J.C.; Agapito, M.T.; Garcia-Herrero, I.; Recio, J.M.: Effects of EGTA and calmodulin, neutral thiol proteinases and protein kinase C inhibitors on loss of chicken pineal serotonin N-acetyltransferase activity. J. Comp. Physiol. B, 159, 583–588 (1989)

    Article  PubMed  CAS  Google Scholar 

  6. Namboodiri, M.A.A.; Brownstein, M.J.; Weller, J.L.; Voisin, P.; Klein, D.C.: Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form. J. Pineal Res., 4, 235–246 (1987)

    Article  PubMed  CAS  Google Scholar 

  7. Morton, D.J.: Effect of various cations on the activity of pineal gland N-acetyltransferase (EC 2.3.1.5) and hydroxyindole-O-methyl transferase (EC 2.1.1.4) in vitro. J. Pineal Res., 4, 161–167 (1987)

    Article  PubMed  CAS  Google Scholar 

  8. Rougraff, P.M.; Paxton, R.: Purification and partial characterization of checken liver acetyl coenzymeA:arylamine N-acetyltransferase. Comp. Biochem. Physiol. B Comp. Biochem., 86, 601–606 (1987)

    Article  CAS  Google Scholar 

  9. Jendryczko, A.; Drozdz, M.: Effects of some complexing agents on acetyl-CoA:arylamine N-acetyltransferase. Rev. Roum. Biochim., 22, 201–203 (1985)

    CAS  Google Scholar 

  10. Gollamudi, R.; Rackley, R.J.; Autian, J.: A new substrate for the measurement of N-acetyltransferase activity. Enzyme, 30, 155–161 (1983)

    PubMed  CAS  Google Scholar 

  11. Paul, R.C.; Ratledge, C: Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes. Biochim. Biophys. Acta, 320, 9–15 (1973)

    PubMed  CAS  Google Scholar 

  12. Barenholz, Y.; Edelman, I.; Gatt, S.: Amine:acetyl CoenzymeA acetyltrans-ferase from the soluble fraction of Hansenula ciferri: isolation and properties. Biochim. Biophys. Acta, 358, 262–274 (1974)

    CAS  Google Scholar 

  13. Andres, H.H.; Kolb, H.J.; Weiss, L.: Purification and physical-chemical properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver. Biochim. Biophys. Acta, 746, 182–192 (1983)

    PubMed  CAS  Google Scholar 

  14. Andres, H.H.; Kolb, H.J.; Schreiber, R.J.; Weiss, L.: Characterization of the active site, substrate specificity and kinetic properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver. Biochim. Biophys. Acta, 746, 193–201 (1983)

    PubMed  CAS  Google Scholar 

  15. Hasmann, M.J.; Seidl, P.H.; Engelhardt, G.; Schleifer, K.H.: Acetyl-coenzyme A:arylamine N-acetyltransferases in microorganisms: screening and isolation of an enzyme from Bacillus cereus. Arch. Microbiol., 146, 275–279 (1986)

    Article  PubMed  CAS  Google Scholar 

  16. Yu, P.H.; Boulton, A.A.: N-Acylation of tyramines: purification and characterization of an arylamine N-acetyltransferase from rat brain and liver. Can. J. Biochem., 57, 1204–1209 (1979)

    Article  PubMed  CAS  Google Scholar 

  17. Weber, W.W.: N-Acetyltransferase (mammalian liver). Methods Enzymol., 17B, 805–811 (1971)

    Google Scholar 

  18. Mannens, G.; Siegers, G.; Claeys, A.: Assay for acetyl-CoA:arylamine N-acetyltransferase by high-performance liquid chromatography applied to serotonin N-acetylation. Biochim. Biophys. Acta, 1037, 1–6 (1990)

    PubMed  CAS  Google Scholar 

  19. Morrissey, J.J.; Edwards, S.B.; Lovenberg, W.: Comparison of rat pineal gland and rat liver serotonin-N-acetyltransferase. Biochem. Biophys. Res. Commun., 77, 118–123 (1977)

    Article  PubMed  CAS  Google Scholar 

  20. Schulte, E.H.; Schloot, W; Goedde, H.W.: Purification of human liver serotonin/isoniazid N-acetyltransferase by preparative polyacrylamide gel electrophoresis and determination of molecular weight. Z. Naturforsch. C, 29c, 661–666 (1974)

    Google Scholar 

  21. Weber, W.W.; King, CM.: N-Acetyltransferase and arylhydroxamic acid acyltransferase. Methods Enzymol., 77, 272–280 (1981)

    Article  PubMed  CAS  Google Scholar 

  22. Ohtomi, M.; Sasaki, M.; Deguchi, T.: Two arylamine N-acetyltransferases from chicken pineal gland as identified by cDNA cloning. Eur. J. Biochem., 185, 253–261 (1989)

    Article  PubMed  CAS  Google Scholar 

  23. Glowinski, I.B.; Weber, W.W.; Fysh, J.M.; Vaught, J.B.; King, CM.: Evidence that arylhydroxamic acid N,O-acyltransferase and the genetically polymorphic N-acetyltransferase are properties of the same enzyme in rabbit liver. J. Biol. Chem., 255, 7883–7890 (1980)

    PubMed  CAS  Google Scholar 

  24. Andres, H.H.; Klem, A.J.; Schopfer, L.M.; Harrison, J.K.; Weber, W.W.: On the active site of liver acetyl-CoA. Arylamine N-acetyltransferase from rapid acetylator rabbits (III/J). J. Biol. Chem., 263, 7521–7527 (1988)

    PubMed  CAS  Google Scholar 

  25. Deguchi, T.; Sakamoto, Y.; Sasaki, Y; Uyemura, K.: Arylamine N-acetyltransferase from chicken liver. I. Monoclonal antibodies, immunoaffinity purification, and amino acid sequences. J. Biol. Chem., 263, 7528–7533 (1988)

    PubMed  CAS  Google Scholar 

  26. Ohsako, S.; Ohtomi, M.; Sakamoto, Y; Uyemura, K.; Deguchi, T.: Arylamine N-acetyltransferase from chicken liver II. Cloning of cDNA and expression in Chinese hamster ovary cells. J. Biol. Chem., 263, 7534–7538 (1988)

    PubMed  CAS  Google Scholar 

  27. Dupret, J.M.; Grant, D.M.: Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2. J. Biol. Chem., 267, 7381–7385 (1992)

    PubMed  CAS  Google Scholar 

  28. Grant, D.M.; Lottspeich, R; Meyer, U.A.: Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver. FEBS Lett, 244, 203–207 (1989)

    Article  PubMed  CAS  Google Scholar 

  29. Hein, D.W.: Acetylator genotype and arylamine-induced carcinogenesis. Biochim. Biophys. Acta, 948, 37–66 (1988)

    PubMed  CAS  Google Scholar 

  30. Zaher, H.; Lindblad, W.J.; Jiang, W.; Doll, M.A.; Hein, D.W.; Svensson, C.K.: Acetyl CoA:arylamine N-acetyltransferase activity in rat hepatocytes cultured on different extracellular matrixes. Toxicol. in Vitro, 11, 271–283 (1997)

    Article  CAS  Google Scholar 

  31. Sticha, K.R.; Sieg, C.A.; Bergstrom, C.P.; Hanna, RE.; Wagner, C.R.: Over-expression and large-scale purification of recombinant hamster polymorphic arylamine N-acetyltransferase as a dihydrofolate reductase fusion protein. Protein Expr. Purif., 10, 141–153 (1997)

    Article  PubMed  CAS  Google Scholar 

  32. Bergstrom, C.P.; Wagner, C.R.; Ann, D.K.; Hanna, P.E.: Hamster mono-morphic arylamine N-acetyltransferase: expression in Escherichia coli and purification. Protein Expr. Purif., 6, 45–55 (1995)

    Article  PubMed  CAS  Google Scholar 

  33. Upton, A.M.; Mushtaq, A.; Victor, T.C.; Sampson, S.L.; Sandy, J.; Smith, D.M.; Van Helden, P.V.; Sim, E.: Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol. Microbiol., 42, 309–317 (2001)

    Article  PubMed  CAS  Google Scholar 

  34. Hickman, D.; Palamanda, J.R.; Unadkat, J.D.; Sim, E.: Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli. Biochem. Pharmacol., 50, 697–703 (1995)

    Article  PubMed  CAS  Google Scholar 

  35. Sticha, K.R.K.; Bergstrom, C.P.; Wagner, C.R.; Hanna, RE.: Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases. Bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene. Biochem. Pharmacol., 56, 47–59 (1998)

    Article  PubMed  CAS  Google Scholar 

  36. Butcher, N.J.; Ilett, K.R; Minchin, R.F.: Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid. Biochem. Pharmacol., 60, 1829–1836 (2000)

    Article  PubMed  CAS  Google Scholar 

  37. Guray, T.; Guvenc, T.: Sheep tissue acetyl coenzyme A-dependent arylamine N-acetyltransferases. Comp. Biochem. Physiol. C, 118C, 305–310 (1997)

    CAS  Google Scholar 

  38. Tsou, M.F.; Chung, J.G.; Wu, L.T.; Cheng, K.S.; Hung, C.F.: Characterization of arylamine N-acetyltransferase in Enterobacter aerogenes. Microbios, 94, 133–143 (1998)

    PubMed  CAS  Google Scholar 

  39. Chen, G.W.; Hung, C.F.; Chang, S.H.; Lin, J.G.; Chung, J.G.: Purification and characterization of an arylamine N-acetyltransferase from Lactobacillus acidophilus. Microbios, 98, 159–174 (1999)

    PubMed  CAS  Google Scholar 

  40. Chung, J.G.: Purification and characterization of an arylamine N-acetyltransferase in the nematode Enterobius vermicularis. Microbios, 98, 15–25 (1999)

    PubMed  CAS  Google Scholar 

  41. Fang, S.H.; Chung, J.G.; Chang, W.C.; Chang, S.S.: Evidence for arylamine N-acetyltransferase activity in the fungi Candida albicans. Toxicol. Lett., 92, 109–116 (1997)

    Article  PubMed  CAS  Google Scholar 

  42. Chung, J.G.; Wang, H.H.; Tsou, M.F.; Hsieh, S.E.; Lo, H.H.; Yen, Y.S.; Chang, S.S.; Wu, L.T.; Lee, J.H.; Hung, C.F.: Evidence for arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori. Toxicol. Lett., 91, 63–71 (1997)

    Article  PubMed  CAS  Google Scholar 

  43. Chung, J.G.; Kuo, H.M.; Lin, T.H.; Ho, C.C.; Lee, J.H.; Lai, J.M.; Levy, G.N.; Weber, W.W.: Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex. Cancer Lett., 106, 1–8 (1996)

    Article  PubMed  CAS  Google Scholar 

  44. Hsieh, S.E.; Lo, H.H.; Chung, J.G.: The characteristics of arylamine N-acetyltransferase in Pseudomonas aeruginosa. Curr. Microbiol., 36, 353–360 (1998)

    Article  PubMed  CAS  Google Scholar 

  45. Chang, F.C.; Chung, J.G.: Evidence for arylamine N-acetyltransferase activity in the Escherichia coli. Curr. Microbiol., 36, 125–130 (1998)

    Article  PubMed  CAS  Google Scholar 

  46. Yeh, C.C.; Hung, C.F.; Wang, W.L.; Chung, J.G.: Kinetics of acetyl coenzyme A:arylamine N-acetyltransferase from rapid and slow acetylator human benign prostatic hyperplasia tissues. Urol. Res., 29, 311–316 (2001)

    Article  PubMed  CAS  Google Scholar 

  47. Mushtaq, A.; Payton, M.; Sim, E.: The COOH terminus of arylamine N-acetyltransferase from Salmonella typhimurium controls enzymic activity. J. Biol. Chem., 277, 12175–12181 (2002)

    Article  PubMed  CAS  Google Scholar 

  48. Goodfellow, G.H.; Dupret, J.M.; Grant, D.M.: Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem. J., 348, 159–166 (2000)

    Article  PubMed  CAS  Google Scholar 

  49. Whitaker, D.P.; Goosey, M.W.: Purification and properties of the enzyme arylamine N-acetyltransferase from the housefly Musca domestica. Biochem. J., 295, 149–154 (1993)

    PubMed  CAS  Google Scholar 

  50. Chung, J.G.; Chen, G.W.; Yeh, H.N.; Hung, C.F.; Huang, D.S.: Kinetics of acetyl coenzyme A:arylamine N-acetyltransferase from the human umbilical cord. Res. Commun. Pharmacol. Toxicol., 2, 193–204 (1997)

    CAS  Google Scholar 

  51. Palamanda, J.R.; Hickman, D.; Ward, A.; Sim, E.; Romkes-Sparks, M.; Unadkat, J.D.: Dapsone acetylation by human liver arylamine N-acetyltrans-ferases and interaction with antiopportunistic infection drugs. Drug Metab. Dispos., 23, 473–477 (1995)

    PubMed  CAS  Google Scholar 

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  1. Institute for Biochemistry, University to Cologne, Zülpicher Strasse 47, 50674, Cologne, Germany

    Dietmar Schomburg , Ida Schomburg  & Antje Chang ,  & 

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(2006). Arylamine N-acetyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37716-6_34

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