This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Axelrod, J.: Purification and properties of phenylethanolamine-N-methyltransferase. J. Biol. Chem., 237, 1657–1660 (1962)
Connett, R.J.; Kirshner, N.: Purification and properties of bovine phenylethanolamine N-methyltransferase. J. Biol. Chem., 245, 329–334 (1970)
Lee, H.-S.; Schulz, A.R.; Fuller, R.W.: Isolation of multiple forms of rabbit-adrenal norepinephrine N-methyltransferase. Arch. Biochem. Biophys., 163, 735–741 (1974)
Pohorecky, L.A.; Baliga, B.S.: Purification and properties of rat adrenal phenylethanolamine-N-methyl transferase. Arch. Biochem. Biophys., 156, 703–711 (1973)
Lee, H.-S.; Schulz, A.R.; Fuller, R.W.: Isolation and purification of rabbit adrenal norephinephrine N-methyl transferase isozymes. Arch. Biochem. Biophys., 185, 222–227 (1978)
Lee, H.-S.; Schulz, A.R.; Fuller, R.W.: The interaction of rabbit adrenal norepinephrine N-methyl transferase isozymes with substrates. Arch. Biochem. Biophys., 185, 228–238 (1978)
Lee, H.-S.; Schulz, A.R.; Fuller, R.W.: Product inhibition studies and the reaction sequence of rabbit adrenal norepinephrine N-methyl transferase isozymes. Arch. Biochem. Biophys., 185, 239–250 (1978)
Harralson, J.D.; Brown, F.C.: Phenylethanolamine-N-methyltransferase:alcohol and the mechanism of action. Arch. Biochem. Biophys., 221, 354–360 (1983)
Hurst, J.H.; Guchhait, R.B.; Billingsley, M.L.; Stolk, J.M.; Lovenberg, W.: Phenylethanolamine N-methyltransferase: notes on its purification from bovine adrenal medulla and separation from protein carboxymethyltransferase. Biochem. Biophys. Res. Commun., 112, 1061–1068 (1983)
Fuller, R.W.: Norepinephrine N-methyltransferase from rabbit adrenal glands. Methods Enzymol., 142, 655–660 (1987)
Fuller, R.W.; Hemrick, S.K.: m-Octopamine as a substrate for norepinephrine N-methyltransferase. IRCS Med. Sci. Libr. Compend., 8, 284 (1980)
Fuller, R.W.; Nagarajan, R.: Inhibition of methyltransferases by some new analogs of S-adenosylhomocysteine. Biochem. Pharmacol., 27, 1981–1983 (1978)
Park, D.H.; Wessel, T.; Baker, H.; Joh, T.H.; Samanta, H.: Characterization of recombinant bovine phenylethanolamine N-methyltransferase expressed in a mouse C127 cell line. Mol. Brain Res., 10, 213–218 (1991)
Wong, D.L.; Yamasaki, L.; Ciaranello, R.D.: Characterization of the isozymes of bovine adrenal medullary phenylethanolamine N-methyltransferase. Brain Res., 410, 32–44 (1987)
Padbury, J.F.; Lam, R.W.; Hobel, C.J.; Fisher, D.A.: Identification and partial purification of phenylethanolamine N-methyl transferase in the developing ovine lung. Pediatr. Res., 17, 362–367 (1983)
Fuller, R.W.; Hemrick, S.K.: Properties of norepinephrine N-methyltransferase from pigeon brain. Pharmacol. Biochem. Behav., 11, 563–566 (1979)
Fuller, R.W.; Molloy, B.B.: Inhibition in vitro of norepinephrine N-methyltransferase by 2-aminotetralins, analogs of phenylethylamines with rigid conformation. Biochem. Pharmacol., 26, 446–447 (1977)
Hoffman, A.R.; Ciaranello, R.D.; Axelrod, J.: Substrate and inhibitor kinetics of bovine phenylethanolamine-N-methyltransferase. Biochem. Pharmacol., 24, 544–546 (1975)
Cubeddu, L.; Gimenez, M.; Goldstein, D.J.: Inhibition of phenylethanolamine-N-methyltransferase by human cerebrospinal fluid-a sodium chloride effect. Biochem. Pharmacol., 25, 2537–2538 (1976)
Begun, J.; McLeish, M.J.; Caine, J.M.; Palant, E.; Grunewald, G.L.; Martin, J.L.: Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration. Acta Crystallogr. Sect. D, D58, 314–315 (2002)
Warthan, M.D.; Freeman, J.G.; Loesser, K.E.; Lewis, C.W.; Hong, M.; Conway, C.M.; Stewart, J.K.: Phenylethanolamine N-methyltransferase expression in mouse thymus and spleen. Brain Behav. Immun., 16, 493–499 (2002)
Kaneda, N.; Hikita, K.; Naruse, Y.; Fukuo, T.; Matsubara, K.; Nagatsu, T.: Identification of the essential cysteinyl residue located in the active site of human phenylethanolamine N-methyltransferase. Biochem. Biophys. Res. Commun., 249, 405–409 (1998)
Ebert, S.N.; Baden, J.M.; Mathers, L.H.; Siddall, B.J.; Wong, D.L.: Expression of phenylethanolamine N-methyltransferase in the embryonic rat heart. J. Mol. Cell. Cardiol., 28, 1653–1658 (1996)
Gearhart, D.A.; Neafsey, E.J.; Collins, M.A.: Phenylethanolamine N-methyltransferase has β-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson’s disease. Neurochem. Int., 40, 611–620 (2002)
Senthilkumaran, B.; Joy, K.P.: Changes in hypothalamic catecholamines, dopamine-β-hydroxylase, and phenylethanolamine-N-methyltransferase in the catfish Heteropneustes fossilis in relation to season, raised photoperiod and temperature, ovariectomy, and estradiol-17β replacement. Gen. Comp. Endocrinol., 97, 121–134 (1995)
Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Slavica, M.; Criscione, K.R.; Borchardt, R.T.; Wang, W.: Synthesis and biochemical evaluation of 3-fluoromethyl-l,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the α(2)-adrenoceptor. J. Med. Chem., 42, 3588–3601 (1999)
Grunewald, G.L.; Dahanukar, V.H.; Jalluri, R.K.; Criscione, K.R.: Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydro-isoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the α 2-adrenoceptor. J. Med. Chem., 42, 118–134 (1999)
Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Criscione, K.R.: Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3,4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the α(2)-adrenoceptor. J. Med. Chem., 42, 3315–3323 (1999)
Grunewald, G.L.; Dahanukar, V.H.; Ching, P.; Criscione, K.R.: Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase. J. Med. Chem., 39, 3539–3546 (1996)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2006). Phenylethanolamine N-methyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases I. Springer Handbook of Enzymes, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37715-8_28
Download citation
DOI: https://doi.org/10.1007/3-540-37715-8_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-31917-7
Online ISBN: 978-3-540-37715-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)