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Kokzidien und Mikrosporidien

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Infektiologie des Gastrointestinaltraktes

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Zusammenfassung

Kokzidien sind humanpathogene, intrazelluläre Protozoen mit weltweiter Verbreitung. Sie bilden Sporen, die mit den Oozysten ausgeschieden werden. Die Oozysten sind wegen ihrer festen Wand sehr umweltresistent, insbesondere auch chlorresistent, was — bedingt durch den fäkal-oralen Übertragungsweg — zu trinkwasser- und nahrungsmittelassoziierten Ausbrüchen geführt hat. Die hier beschriebenen Arten (Cryptosporidium parvum, Isospora belli, Cyclospora cayetanensis und Sarcocystis spp.) rufen gastrointestinale Erkrankungen mit wässriger Diarrhö hervor. Hauptbetroffene sind neben Reisenden insbesondere Immunsupprimierte wie z. B. AIDS-Patienten (Ausnahme Sarcocystis spp.). Daher haben diese Erreger seit Beginn der HIV-/AIDS-Epidemie durch die Zunahme an Infizierten an Bedeutung gewonnen (Chen et al. 2002).

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Literatur

  • Amadi B, Mwiya M, Musuku J et al. (2002) Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 360: 1375–80

    Article  PubMed  Google Scholar 

  • Arness MK, Brown JD, Dubey JP et al. (1999) An outbreak of acute eosinophilic myositis attributed to human Sarcocystis parasitism. Am J Trop Med Hyg 61: 548–53

    PubMed  CAS  Google Scholar 

  • Atherton F, Newman CP, Casemore DP (1995) An outbreak of waterborne cryptosporidiosis associated with a public water supply in the UK. Epidemiol Infect 115: 123–31

    PubMed  CAS  Google Scholar 

  • Benhamou Y, Kapel N, Hoang C et al. (1995) Inefficacy ot intestinal secretory immune response to Cryptosporidium in acquired immunodefiencysyndrome. Gastroenterology 108: 627

    Article  PubMed  CAS  Google Scholar 

  • Bryan RT (1995) Microsporidosis as an AIDS-related opportunistic infection. Clin Infect Dis 21: 62

    Google Scholar 

  • Canning ES, Hollister WS (1992): Human infections with Microsporidia. Rev Med Microbiol 3: 35–44

    Google Scholar 

  • Carr A, Marriott D, Field A et al. (1998) Treatment of HIV-1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapy. Lancet 351: 256–61

    Article  PubMed  CAS  Google Scholar 

  • Casemore DP (1990) Epidemiological aspects of human cryptosporidosis. Epidemiol Infect 104: 1

    Article  PubMed  CAS  Google Scholar 

  • CDC 2004: http://www.dpd.cdc.gov/dpdx/HTML/Isosporiasis.htm

    Google Scholar 

  • CDC 2004: http://www.dpd.cdc.gov/dpdx/HTML/microsporidosis.htm

    Google Scholar 

  • Chen XM, Keithly JS, Paya CV et al. (2002): Cryptosporidiosis. N Engl J Med 346: 1723–31

    Article  PubMed  Google Scholar 

  • Clayton F, Heller T, Kotler DP (1994) Variation in the enteric distribution of cryptosporidia in aquired immune defiency syndrome. Am J Clin Pathol 102: 420

    PubMed  CAS  Google Scholar 

  • Current WL (1989) Cryptosporidium spp. In: Walzer PD, Genta RM (eds) Parasitic infections in the compromised host. Marcel Dekker, New York, pp 281–341

    Google Scholar 

  • Current WL, Garcia LS (1991) Cryptosporidosis. Clin Microbiol Rev 4: 325

    PubMed  CAS  Google Scholar 

  • Curry A, Smith HV (1998) Emerging pathogens: Isospora, Cyclospora and microsporidia. Parasitology 117: 143–59

    Article  Google Scholar 

  • De Hovitz JA, Pape JW, Boncy M, (1986) Clinical manifestations and therapy of Isospora belli in patients with the acquired immune defiency syndrome. N Engl J Med 315: 87

    Article  Google Scholar 

  • Didier ES (1998) Microsporidosis. Clin Infect Dis 27: 1

    PubMed  CAS  Google Scholar 

  • Doller PC, Dietrich K, Filipp N et al. (2002): Cyclosporiasis outbreak in Germany associated with the consumption of salad. Emerg Infect Dis 8: 992–4

    PubMed  Google Scholar 

  • Dore GJ, Marriott DJ, Hing MC et al. (1995): Disseminated microsporidosis due to Septata intestinalis in nine patients infected with the human immunodefiency virus: response to therapy with albendazole. Clin Infect Dis 21: 70

    PubMed  CAS  Google Scholar 

  • Drugs for Parasitic Infections (2004) Medical Lett Drugs Ther (online: www.medletter.com/freedocs/parasitic.pdf)

    Google Scholar 

  • Dubey JP, Fayer R (1983) Sarcocystosis. Br Vet J 139: 371–377

    PubMed  CAS  Google Scholar 

  • Dupont HL, Chappell CL, Sterling CR et al. (1995) The infectivity of Cryptosporidium parvum in healthy volunteers. N Engl J Med 332: 855–859

    Article  PubMed  CAS  Google Scholar 

  • Eberhard ML, Pieniazek NJ, Arrowood MJ (1997) Laboratory diagnosis of Cyclospora infections. Arch Pathol Lab Med 121: 792–797

    PubMed  CAS  Google Scholar 

  • Ebrahimzadeh A, Bottone EJ (1996) Persistent diarrhea caused by Isospora belli: therapeutic response to pyrimethamine and sulfadiazine. Diagn Microbiol Infect Dis 26: 87–89

    Article  PubMed  CAS  Google Scholar 

  • Farthing M.J.G., Cevallos A., Kelly P (1996) Intestinal Protozoa. In: Cook GC (ed) Manson’s Tropical Diseases. W.B. Saunders, London, pp 1255–1290

    Google Scholar 

  • Fayer R, Morgan U, Upton S. (2000) Epidemiology of Cryptosporidium: transmission, detection and identification. Int J Pathol 30: 1305–1322

    CAS  Google Scholar 

  • Fayer R, Ungar BL (1986) Cryptosporidium spp. and cryptosporidosis. Microbiol Rev 50: 458

    PubMed  CAS  Google Scholar 

  • Flanigan TP (1994) Human immunodefiency virus infection and cryptosporidosis: protective immune responses. Am J Trop Med Hyg 50: 29–35

    PubMed  CAS  Google Scholar 

  • Fleischer K, Burchard G, Jantischke K (2000) Giardiasis und andere intestinale Protozoeninfektionen. In: Lang W, Löcher T (Hrsg) Tropenmedizin in Klinik und Praxis. Thieme, Stuttgart, S 86–94

    Google Scholar 

  • Fournier S, Liguory O, Garrait V et al. (1998) Microsporidosis due to Enterocytozoon bieneusi infection as possible cause of traveller’s diarrhoe. Eur J Clin Microbiol Infect Dis 17: 743

    Article  PubMed  CAS  Google Scholar 

  • Genta RM, Chappel CL, White AC jr et al. (1993) Duodenal morphology and intensity of infection in AIDS-related cryptosporidosis. Gastroenterol 105: 1769–1775

    CAS  Google Scholar 

  • Goodgame RW, Kimball K, Ou C-N et al. (1994) Intestinal function and injury in acquired immunodefiency syndrome related cryptosporidosis. Gastroenterology 106: 28

    Google Scholar 

  • Gross TL. Wheat J, Bartlett M et al. (1986) AIDS and multiple system involvement with cryptosporidium. Am J Gastroentererol 81: 456

    CAS  Google Scholar 

  • Haberkorn A (1996) Chemotherapy of human and animal coccidioses: state and perspectives. Parasitol Res 82: 193–9

    Article  PubMed  CAS  Google Scholar 

  • Hashmey R, Genta RM, White jr AC (1997) Parasites and Diarrhea. I: Protozoans and Diarrhea. J Travel Med 4: 17–31

    Article  PubMed  Google Scholar 

  • Herwaldt BL (2000) Cyclospora cayetanensis: a review, focusing on the outbreaks of cyclosporiasis in the 1990s. Clin Infect Dis 31: 1040–1057

    Article  PubMed  CAS  Google Scholar 

  • Hewitt RG, Yiannoutsos CT, Higgs ES et al. (2000) Paromomycin: no more effective than placebo for treatment of cryptosporidiosis in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trial Group. Clin Infect Dis 31: 1084–92

    Article  PubMed  CAS  Google Scholar 

  • Himy R, Villard O, Kremer M (1993) Cyclosporidia: a review. J Travel Med 2: 33–36

    Article  Google Scholar 

  • Janitschke K, Kimming P, Seitz HM et al. (1998) Parasitosen. 4/1998. Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik. Gustav Fischer, Stuttgart Jena Lübeck Ulm

    Google Scholar 

  • Jelinek T, Lotze M, Eichenlaub S et al. (1997) Prevalence of infection with Cryptosporidium parvum and Cyclospora cayetanensis among international travelers. Gut 41: 801

    Article  PubMed  CAS  Google Scholar 

  • Junod C (1988) Isospora belli coccidiosis in immunocompetent subjects (a study of 40 cases seen in Paris). Bull Soc Pathol Exot Filiales 81: 317–325

    PubMed  CAS  Google Scholar 

  • Kain KC (1995) Chapter 74. Intestinal Infection with other Protozoa. In: Blaser MJ, Smith PD, Ravdin JI (eds) Infections of the gastrointestinal tract. Raven Press, New York, pp 1141–1152

    Google Scholar 

  • Kuhls TL, Mosier DA, Crawford DL et al. (1994) Seroprevalence of cryptosporidial antibodies during infancy, childhood, and adolescence. Clin Infect Dis 18: 731

    PubMed  CAS  Google Scholar 

  • Le Moing V, Bissuel F, Costagliola D et al. (1998) Decreased prevalence of intestinal cryptosporidosis in HIV-infected patients concomitant to the widespread use or protease inhibitors (letter). AIDS 12: 1395

    PubMed  Google Scholar 

  • Leder K, Weller PF (2004a): Cryptosporidiosis. UptoDate Vol. 12.3

    Google Scholar 

  • Leder K, Weller PF (2004b): Microsporidosis. UptoDate Vol. 12.3

    Google Scholar 

  • Lindsay DS, Dubey JP, Blagburn BL (1997) Biology of Isospora spp. from humans, nonhuman primates, and domestic animals. Clin Microbiol Rev 10: 19–34

    PubMed  CAS  Google Scholar 

  • Looney WJ (1998) Cyclospora species as a cause of diarrhoea in humans. Br J Biomed Sci 55: 157–61

    PubMed  CAS  Google Scholar 

  • Maggi P, Larocca AM, Quarto M et al. (2000) Effect of antiretroviral therapy on cryptosporidiosis and microsporidiosis in patients infected with human immunodeficiency virus type 1. Eur J Clin Microbiol Infect Dis 19: 213–7

    Article  PubMed  CAS  Google Scholar 

  • Marshall MM, Naumovitz D, Ortega Y (1997) Waterborne protozoan pathogens. Clin Microbiol Rev 10: 67–85

    PubMed  CAS  Google Scholar 

  • Mathan MM, Venkatesan S, George R et al. (1985) Cryptosporidosis and diarrhoe in southern Indian children. Lancet 2: 1172–1175

    Article  PubMed  CAS  Google Scholar 

  • NN (1999) www.cdc.gov/ncidod/diseases/crypto/hivaids.htm

    Google Scholar 

  • No authors listed (1999) Cryptosporidium in water and the immunocompromised. Commun Dis Rep CDR Wkly 9: 289–292

    Google Scholar 

  • Ortega YR, Sterling CR, Gilman RH (1998) Cyclospora cayetanensis. Adv Parasitol 40: 399–418

    Article  PubMed  CAS  Google Scholar 

  • Pieniazek NJ, Herwaldt BL (1997) Reevaluating the molecular taxonomy: Is human-associated Cyclospora a mammalian Eimeria species? Emerging Infect Dis 3: 381–383

    Article  PubMed  CAS  Google Scholar 

  • Pol S, Romana C, Richard S (1993) Micorsporidia infection in patients with AIDS and unexplained cholangitis. N Engl J Med 328: 95–99

    Article  PubMed  CAS  Google Scholar 

  • Rossignol JF; Ayoub A; Ayers MS (2001) Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, doubleblind, placebo-controlled study of Nitazoxanide. J Infect Dis 184: 103–106

    Article  PubMed  CAS  Google Scholar 

  • Sandfort J, Hannemann A, Gelderblom H et al. (1994) Enterocytozoon bieneusi infection in an immunocompetent patient who had acute diarrhea and who was not infected with the Human Immunodefiency Virus. Clin Infect Dis 19: 514–516

    PubMed  CAS  Google Scholar 

  • Smith HV, Rose JB (1990) Waterborne cryptosporidosis. Parasitol Today 6: 8–12

    Article  PubMed  CAS  Google Scholar 

  • Soave R, Johnson WD jr. (1988) Cryptosporidium and Isospora belli infections. J Infect Dis 157: 225

    PubMed  CAS  Google Scholar 

  • V et al. (1989) Cryptosporidosis in a rural community in central Mexico. J Infect Dis 159: 1160–1163

    Google Scholar 

  • Ungar BL, Gilman RH, Lanata CF et al. (1988) Seroepidemiology of Cryptosporidium infection in two Latin American populations. J Infect Dis 157: 551

    PubMed  CAS  Google Scholar 

  • Ungar BL, Mulligan M, Nutman TB (1989) Serologic evidence of Cryptosporidium infection in US volunteers before and during Peace Corps service in Africa. Arch Intern Med 149: 894

    Article  PubMed  CAS  Google Scholar 

  • Ungar BLP (1990) Cryptosporidosis in humans (Homo sapiens). In: Dubey JP, Speer CA, Fayer R (eds) Cryptosporidosis of man and animals. CRC Press, Boca Raton, FL, pp 59–82

    Google Scholar 

  • Varea M, Clavel A, Doiz O et al. (1998) Fuchsin fluorescence and autofluorescence in Cryptosporidium, Isospora and Cyclospora oocysts. Int J Parasitol 28: 1881–3

    Article  PubMed  CAS  Google Scholar 

  • Verdier RI, Fitzgerald DW, Johnson WD et al. (2000) Trimethoprim-sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospora belli and Cyclospora cayetanensis infection in HIV-infected patients. A randomized, controlled trial. Ann Intern Med 132: 885–888

    PubMed  CAS  Google Scholar 

  • Weller PF (2004): Isospora belli Infection. UptoDate 2004. Vol 12.3

    Google Scholar 

  • Wilairatana P, Radomyos P, Radomyos B et al. (1996) Intestinal sarcocystosis in Thai laborers. Southeast Asian J Trop Med Public Health 27: 43–6

    PubMed  CAS  Google Scholar 

  • Xiao L, Fayer R, Ryan U et al. (2004): Cryptosporidium taxonomy: recent advances and implications for public health. Clin Microbiol Rev 17: 72–97

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik I, Klinikum der Johann Wolfgang, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main

    Dr. med. C. Schieferstein

  2. Medizinische Klinik II, Klinikum der Johann Wolfgang, Goethe-Universität, Theodor-Stern-Kai, 760590, Frankfurt am Main

    Prof. Dr. med. G. Just-Nübling

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  1. Dr. med. C. Schieferstein
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Editors and Affiliations

  1. Zentrum der Inneren Medizin, Medizinische Klinik I des Universitätsklinikums Frankfurt/Main, Theodor-Stern-Kai 7, 60590, Frankfurt/Main

    Wolfgang F. Caspary  & Jürgen Stein  & 

  2. Abteilung für Mikrobiologie und Hygiene, Universitätsklinikum Freiburg, Hermann-Herder-Str. 11, 79104, Freiburg

    Manfred Kist

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Schieferstein, C., Just-Nübling, G. (2006). Kokzidien und Mikrosporidien. In: Caspary, W.F., Kist, M., Stein, J. (eds) Infektiologie des Gastrointestinaltraktes. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37211-3_42

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  • DOI: https://doi.org/10.1007/3-540-37211-3_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41359-2

  • Online ISBN: 978-3-540-37211-0

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