Bakterielle Überbesiedlung

  • W. F. Caspary
  • J. Stein


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  1. Attar A, Flourie B, Rambaud JC et al. (1999) Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: A crossover, randomized trial. Gastroenterology 117: 794–799PubMedCrossRefGoogle Scholar
  2. Bardham FK, Gyr K, Beglinger C et al. (1992) Diagnosis of bacterial overgrowth after culturing small bowel aspirate obtained during routine upper gastrointestinal endoscopy. Scand J Gastroenterol 27: 253–258Google Scholar
  3. Bishop RF, Anderson CM (1967) Bacterial flora of the stomach and small inestine in children with intestinal obtruction. Arch Dis Child 35: 487–489Google Scholar
  4. Bjorneklett A, Fausa O, Midtvedt T (1983) Small bowel bacterial overgrowth in the postgastrectomy syndrome. Scand J Gastroenterol 18: 277–287PubMedGoogle Scholar
  5. Bjorneklett A, Fausa O, Midtvedt T (1983) Bacterial overgrowth in jejunal and ileal disease. Scand J Gastroenterol 18: 289–298PubMedGoogle Scholar
  6. Bouhnik Y, Alain S, Attar A (1999) Bacterial populations contaminating the upper gut in patients with small intestinal bacterial overgrowth syndrome. Am J Gastroenterol 94: 1327–1331PubMedCrossRefGoogle Scholar
  7. Brandt LJ, Bernstein LH, Wagle A (1977). Production of vitamin B12 analogues in patients with small-bowel bacterial overgrowth. Ann Intern Med 87: 546–551PubMedGoogle Scholar
  8. Brummer RJ, Armbrecht U, Bosaeus I et al. (1985) The hydrogen (H2) breath test. Sampling methods and the influence of dietary fibre on fasting level. Scand J Gastroenterol 20: 1007–1013PubMedGoogle Scholar
  9. Caspary WF, Reimold WV (1976). Klinische Bedeutung des 14C-Glykocholat-Atemtests in der gastroenterologischen Diagnostik bei Erkrankungen mit gesteigerter Dekonjugation von Gallensäuren. Dtsch Med Wschr 101: 353–360PubMedCrossRefGoogle Scholar
  10. Chang CS, Chen GH, Lien HC, Yeh HZ (1998) Small intestine dysmotility and bacterial overgrowth in cirrhotic patients with spontaneous bacterial peritonitis. Hepatology 28: 1187–1190PubMedCrossRefGoogle Scholar
  11. Corazza GR, Menozzi MG, Strocchi A et al. (1990) The diagnosis of small bowel bacterial overgrowth. Reliability of jejunal culture and inadequacy of breath hydrogen testing. Gastroenterology 98: 302–309PubMedGoogle Scholar
  12. Dellert SF, Nowicki MJ, Farrell MK et al. (1997) The 13C-xylose breath test for the diagnosis of small bowel bacterial overgrowth in children. J Pediatr Gastroenterol Nutr 25: 153–158PubMedCrossRefGoogle Scholar
  13. Di Stefano M, Malservisi S, Veneto G et al. (2000) Rifaximin versus chlortetracycline in the short-term treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther 14: 551–556PubMedCrossRefGoogle Scholar
  14. Di Stefano M, Miceli E, Missanelli A et al. (2005) Absorbable vs. non-absorbable antibiotics in the treatment of small intestine bacterial overgrowth in patients with blind-loop syndrome. Aliment Pharmacol Ther 21: 985–992PubMedCrossRefGoogle Scholar
  15. Fried M, Siegrist H, Frei R et al. (1994). Duodenal bacterial overgrowth during treatment in outpatients with omeprazole. Gut 35: 23–26PubMedGoogle Scholar
  16. Ghoshal U, Ghoshal UC, Ranjan P et al. (2003) Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics. BMC Gastroenterol 3: 9PubMedCrossRefGoogle Scholar
  17. Gorbach SL, Nahas L, Lerner PI, Weinstein L (1967) Studies of intestinal microflora. I. Effects of diet, age, and periodic sampling on numbers of fecal microorganisms in man. Gastroenterology. 53: 845–855PubMedGoogle Scholar
  18. Gregg CR, Toskes PP (2002) Enteric bacterial flora and small bowel bacterial overgrowth syndrome. In: Feldman M, Scharschmidt BF, Sleisenger MH (eds) Gastrointestinal and liver disease. W.B. Saunders, Philadelphia, pp 1783–1793Google Scholar
  19. Guarner C, Soriano G (2005) Bacterial translocation and its consequences in patients with cirrhosis. Eur J Gastroenterol Hepatol 17: 27–31PubMedCrossRefGoogle Scholar
  20. Gunnarsdottir SA, Sadik R, Shev S et al. (2003) Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension. Am J Gastroenterol 98: 1362–1370PubMedCrossRefGoogle Scholar
  21. Hoverstad T, Bjoneklet A, Fausa O, Midtvedt T (1985) Short-chain fatty acids in the small-bowel bacterial overgrowth syndrome. Scand J Gastroenterol 20: 492–499PubMedGoogle Scholar
  22. Husebye E (1995) Gastrointestinal motility disorders and bacterial overgrowth. J Intern Med 237: 419–427PubMedCrossRefGoogle Scholar
  23. Husebye E, Skar V, Hoverstad T, Melby K (1992) Fasting hypochlorhydria with gram positive gastric flora is highly prevalent in healthy old people. Gut 33: 1331–1337PubMedGoogle Scholar
  24. Kerlin P, Wong L (1988) Breath hydrogen testing in bacterial overgrowth of the small intestine. Gastroenterology 95: 982–987PubMedGoogle Scholar
  25. King CE, Toskes P (1981) Protein-losing enteropathy in the human and experimental rat blind loop syndrome. Gastroenterology 80: 504–511PubMedGoogle Scholar
  26. King CE, Toskes PP, Guilarte TR, Lorenz E, Welkos SL (1980) Comparison of the one-gram D-[14C]xylose breath test to the [14C]bile acid breath test in patients with small intestinal bacterial overgrowth. Dig Dis Sci 25: 53–58PubMedCrossRefGoogle Scholar
  27. Lauritano EC, Gabrielli M, Lupascu A et al. (2005) Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther 22: 31–35PubMedCrossRefGoogle Scholar
  28. Li E (1999) Bacterial overgrowth. In: Yamada T, Alpers DH, Laine L, Owyang C, Powell DW (eds) Textbook of Gastroenterology. Lippincott Williams & Wilkins, Philadelphia, pp 1697–1703Google Scholar
  29. Lichtman SN, Keku J, Schwab JH, Sartor RB (1991) Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology 100: 512–519Google Scholar
  30. Lin HC (2004) Small intestinal bacterial overgrowth: A framework for understanding irritable bowel disease. JAMA 292: 852–858PubMedCrossRefGoogle Scholar
  31. Lupascu A, Gabrielli M, Lauritano EC et al. (2005) Hydrogene glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome. Aliment Pharmacol Ther 22: 1157–1160PubMedCrossRefGoogle Scholar
  32. Madrid AM, Hurtado C, Venegas M et al. (2001) Long-Term treatment with cisapride and antibiotics in liver cirrhosis: effect on small intestinal motility, bacterial overgrowth, and liver function. Am J Gastroenterol 96: 1251–1255PubMedCrossRefGoogle Scholar
  33. Morencos FC, de las Heras Castano G, Martin Ramos L (1995). Small bowel bacterial overgrowth in patients with alcoholic cirrhosis. Dig Dis Sci 40: 1252–1256PubMedCrossRefGoogle Scholar
  34. Nayak AK, Karnad DR, Abraham P et al. (1997) Metronidazole relieves symptoms in irritable bowel syndrome: the confusion with so-called »chronic amebiasis«. Indian J Gastroenterol 16: 137–139PubMedGoogle Scholar
  35. Pelosini I, Scarpignato C (2005) Rifaximin, a peculiar rifamycin derivative: established and potential clinical use outside the gastrointestinal tract. Chemotherapy 51: 122–130PubMedCrossRefGoogle Scholar
  36. Pimentel M, Soffer E, Chow EJ et al. (2002) Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth. Dig Dis Sci 47: 2639–2643PubMedCrossRefGoogle Scholar
  37. Pimentel M, Chow EJ, Lin HC (2003) Normalization of lactulose breath testing correlated with symptom improvement in irritable bowel syndrome: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 98: 412–419PubMedGoogle Scholar
  38. Riordan SM, McIver CJ, Walker BM et al. (1996) The lactulose breath tests and small intestinal overgrowth. Am J Gastroenterol 91: 1795–1799PubMedGoogle Scholar
  39. Riordan SM, McIver CJ, Wakefield D et al. (1997) Small intestinal bacterial overgrowth in the symptomatic elderly. Am J Gastroenterol 92: 47–51PubMedGoogle Scholar
  40. Romagnuolo J, Schiller D, Bailey RJ (2002) Using breath tests wisely used in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpreatation. Am J Gastroenterol 97: 1113–1116PubMedCrossRefGoogle Scholar
  41. Rumessen JJ, Gudmand-Hoyer E, Bachmann E, Justesen T (1985) Diagnosis of bacterial overgrowth of the small intestine. Comparison of the 14C-D-xylose breath test and jejunal cultures in 60 patients. Scand J Gastroenterol 20: 1267–1275PubMedGoogle Scholar
  42. Saltzman JR, Kowdley KV, Pedrosa MC et al. (1994) Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects. Gastroenterology 106: 615–623PubMedGoogle Scholar
  43. Scott LD, Cahall DL (1982) Influence of the interdigestive myoelectric complex on enteric flora in the rat. Gastroenterology 82: 737–745PubMedGoogle Scholar
  44. Sharma BK, Santana IA, Wood EC et al. (19984) Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole. Br Med J 289: 717–719Google Scholar
  45. Sherman P, Lichtman S (1987) Small bowel bacterial overgrowth syndrome. Dig Dis. 5: 157–171PubMedCrossRefGoogle Scholar
  46. Sherman P, Wesley A, Forstner GG (1985) Sequential disaccharidase loss in rat intestinal blind loops: impact of malnutrition. Am J Physiol 248: G626–G632PubMedGoogle Scholar
  47. Shindo K, Machida M, Koide K et al. (1998) Deconjugation ability of bacteria isolated from the jejunal fluid of patients with progressive systemic sclerosis and its gastric pH. Hepatogastroenterology 45: 1643–1650PubMedGoogle Scholar
  48. Solomons NW, Schoeller DA, Wagonfeld JB, Ott D, Rosenberg IH, Klein PD (1977) Application of a stable isotope (13C)-labeled glycocholate breath test to the diagnosis of bacterial overgrowth. J Lab Clin Med 90: 431–439PubMedGoogle Scholar
  49. Soudah HC, Hasler WI, Owyang C (1991) Effect of octreotide on intestinal motility and bacterial overgrowth in scleroderma. New Engl J Med 325: 1461–1467PubMedCrossRefGoogle Scholar
  50. Stein J, Lembcke B (2004) Bakterielle Fehlbesiedlung. In: Caspary WF, Mössner J, Stein J (Hrsg) Therapie gastroenterologischer Krankheiten. Springer, Berlin Heidelberg New York, S 232–238Google Scholar
  51. Stockbruegger RW, Cotton PB et al. (1984) Pernicious anaemia, intragastric bacterial overgrowth, and possible consequences. Scand J Gastroenterol 19: 355–364PubMedGoogle Scholar
  52. Stotzer PO, Blomberg L, Conway PL et al. (1996) Probiotic treatment of small bacterial overgrowth by Lactobacillus fermentus KLD. Scand J Infect Dis 28: 615PubMedGoogle Scholar
  53. Thorens J, Froehlich F, Schwizer W et al. (1996) Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Gut 39: 54–59PubMedGoogle Scholar
  54. Trespi E, Ferrieri A (1999) Intestinal bacterial overgrowth during chronic pancreatitis. Curr Med Res Opin 15: 47–52PubMedCrossRefGoogle Scholar
  55. Vanderhoof JA, Young RJ (1997) Probiotic therapy in children with short bowel syndrome and bacterial overgrowth (abstract). Gastroenterology 112: A916Google Scholar
  56. Vanderhoof JA, Young RJ, Murray N, Kaufmann SS (1998) Treatment strategies for small bowel bacterial overgrowth. J Pediatr Gastroenterol Nutr 27: 155–160PubMedCrossRefGoogle Scholar
  57. Wigg AJ, Roberts-Thomson IC, Dymock RB et al. (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48: 206–211PubMedCrossRefGoogle Scholar
  58. Williams C, McColl KEL (2005) Proton pump inhibitors and bacterial overgrowth. Aliment Pharmacol Ther 23: 3–10CrossRefGoogle Scholar
  59. Yang C-Y, Chang C-S, Chen G-H (1998) Small-intestinal bacterial overgrowth in patients with liver cirrhosis, diagnosed with glucose H2 or CH4 breath test. Scand J Gastroenterol 33: 867–871PubMedCrossRefGoogle Scholar
  60. Welkos SL, Toskes PP, Baer H, Smith GW (1981) Importance of anaerobic bacteria in the cobalamin malabsorption of the experimental rat blind loop syndrome. Gastroenterology 80: 313–320PubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag Heidelberg 2006

Authors and Affiliations

  • W. F. Caspary
    • 1
  • J. Stein
    • 1
  1. 1.Medizinische Klinik I, Klinikum der Johann WolfgangGoethe-UniversitätFrankfurt am Main

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