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Epidemiologie und Diagnostik der Helicobacter pylori-Infektion

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Infektiologie des Gastrointestinaltraktes
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Zusammenfassung

Die Helicobacter pylori-Infektion ist die zweithäufigste bakterielle Infektionskrankheit des Menschen. Über die Hälfte der Weltbevölkerung ist mit diesem Organismus infiziert (Suerbaum u. Michetti 2002). Forschungsergebnisse der letzten Jahre haben gezeigt, dass Helicobacter pylori (H. pylori) den Menschen wahrscheinlich bereits seit der Entstehung der Spezies Homo sapiens bei seiner Wanderung »out of Africa« und der folgenden Besiedlung der Welt begleitet hat (Falush et al. 2003). Obwohl die Prävalenz der Infektion in den westlichen Industrieländern zurückgeht, verursacht die H. pylori-Infektion weiterhin etwa 500.000 Todesfälle durch Magenkarzinom pro Jahr (Levi et al. 2004). Auch die anderen Folgekrankheiten der H. pylori-Infektion, wie Ulkuskrankheit, Magenschleimhautatrophie und MALT-Lymphom rufen erhebliche Morbidität und Mortalität hervor.

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Literatur

  • Anonymus (1995) Leitlinie der Deutschen Gesellschaft für Verdauungs-und Stoffwechselkrankheiten. Diagnostik und Therapie der Helicobacter-pylori-Infektion. Z Gastroenterol 34: 392–401

    Google Scholar 

  • Apel I, Jacobs E, Kist M, Bredt W (1988) Antibody response of patients against a 120 kDa surface protein of Campylobacter pylori. Zentralbl Bakteriol Mikrobiol Hyg [A] 268: 271–276

    CAS  Google Scholar 

  • Bizzozero G (1893) Über die schlauchförmigen Drüsen des Magendarmkanals und die Beziehungen ihres Epithels zu dem Oberflächenepithel der Schleimhaut. Arch Micr Anat 42: 82

    Article  Google Scholar 

  • Braden B, Caspary WF (2001) Detection of Helicobacter pylori infection: when to perform which test ? Ann Med 33: 91–97

    PubMed  CAS  Google Scholar 

  • Braden B, Duan LP, Caspary WF, Lembcke B (1994) More convenient 13Curea breath test modifications still meet the criteria for valid diagnosis of Helicobacter pylori infection. Z Gastroenterol 32: 198–202

    PubMed  CAS  Google Scholar 

  • Braden B, Schafer F, Caspary WF, Lembcke B (1996) Nondispersive isotope-selective infrared spectroscopy: a new analytical method for 13C-urea breath tests. Scand J Gastroenterol 31: 442–445

    PubMed  CAS  Google Scholar 

  • Carvalho Costa CL, Rocha GA et al. (2003) Evaluation of [13C]urea breath test and Helicobacter pylori stool antigen test for diagnosis of H. pylori infection in children from a developing country. J Clin Microbiol 41: 3334–3335

    Article  CAS  Google Scholar 

  • Censini S, Lange C, Xiang Z et al. (1996) cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 93: 14648–14653

    Article  PubMed  CAS  Google Scholar 

  • Cutler AF, Havstad S, Ma CK, Blaser MJ, Perez-Perez GI, Schubert TT (1995) Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology 109: 136–141

    Article  PubMed  CAS  Google Scholar 

  • Dunn BE, Cohen H, Blaser MJ (1997) Helicobacter pylori. Clin Microbiol Rev 10: 720–741

    PubMed  CAS  Google Scholar 

  • Fabris P, Bozzola L, Benedetti P et al. (1997) H. pylori infection in HIV-positive patients. A serohistological study. Dig Dis Sci 42: 289–292

    Article  PubMed  CAS  Google Scholar 

  • Falush D, Wirth T, Linz B et al. (2003) Traces of human migrations in Helicobacter pylori populations. Science 299: 1582–1585

    Article  PubMed  CAS  Google Scholar 

  • Genta RM, Graham DY (1994) Comparison of biopsy sites for the histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distribution. Gastrointest Endosc 40: 342–345

    Article  PubMed  CAS  Google Scholar 

  • Gisbert JP, Pajares JM (2004) Stool antigen test for the diagnosis of Helicobacter pylori infection: a systematic review. Helicobacter 9: 347–368

    Article  PubMed  Google Scholar 

  • Glocker E, Kist M (2004) Rapid detection of point mutations in the gyrA gene of Helicobacter pylori conferring resistance to ciprofloxacin by a fluorescence resonance energy transfer-based real-time PCR approach. J Clin Microbiol 42: 2241–2246

    Article  PubMed  CAS  Google Scholar 

  • Graham DY, Evans DJ Jr., Peacock J, Baker JT, Schrier WH (1996) Comparison of rapid serological tests (FlexSure HP and QuickVue) with conventional ELISA for detection of Helicobacter pylori infection. Am J Gastroenterol 91: 942–948

    PubMed  CAS  Google Scholar 

  • Graham DY, Runke D, Anderson SY, Malaty HM, Klein PD (1999) Citric acid as the test meal for the 13C-urea breath test. Am J Gastroenterol 94: 1214–1217

    Article  PubMed  CAS  Google Scholar 

  • Graham DY, Opekun AR, Hammoud F, Yamaoka Y, Reddy R, Osato MS, El Zimaity HM (2003) Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors. Am J Gastroenterol 98: 1005–1009

    Article  PubMed  CAS  Google Scholar 

  • He Q, Wang JP, Osato M, Lachman LB (2002) Real-time quantitative PCR for detection of Helicobacter pylori. J Clin Microbiol 40: 3720–3728

    Article  PubMed  CAS  Google Scholar 

  • Jaskowski TD, Martins TB, Hill HR, Litwin CM (1997) Immunoglobulin A antibodies to Helicobacter pylori. J Clin Microbiol 35: 2999–3000

    PubMed  CAS  Google Scholar 

  • Kimmel B, Bosserhoff A, Frank R, Gross R, Goebel W, Beier D (2000) Identification of immunodominant antigens from Helicobacter pylori and evaluation of their reactivities with sera from patients with different gastroduodenal pathologies. Infect Immun 68: 915–920

    Article  PubMed  CAS  Google Scholar 

  • Kist, M, Glocker, E (2003) Helicobacter pylori Infektionen: ResiNet — eine bundesweite Sentinelstudie zur Resistenzentwicklung. Epidemiologisches Bulletin 2003/47: 389–391

    Google Scholar 

  • Kist M, Strobel S, Kirchner T, Dammann HG (1999) Impact of ELISA and immunoblot as diagnostic tools one year after eradication of Helicobacter pylori in a multicentre treatment study. FEMS Immunol Med Microbiol 24: 239–242

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi D, Eishi Y, Ohkusa T et al. (2002) Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J Med Microbiol 51: 305–311

    PubMed  CAS  Google Scholar 

  • Koletzko S, Haisch M, Seeboth I, Braden B, Hengels K, Koletzko B, Hering P (1995) Isotope-selective non-dispersive infrared spectrometry for detection of Helicobacter pylori infection with 13C-urea breath test. Lancet 345: 961–962

    Article  PubMed  CAS  Google Scholar 

  • Koletzko S, Konstantopoulos N, Bosman D, Feydt-Schmidt A, Van Der EA, Kalach N, Raymond J, Russmann H (2003) Evaluation of a novel monoclonal enzyme immunoassay for detection of Helicobacter pylori antigen in stool from children. Gut 52: 804–806

    Article  PubMed  CAS  Google Scholar 

  • Konjetzny GE (1923) Chronische Gastritis und Duodenitis als Ursache des Magenduodenalgeschwürs. Beiträge zur pathologischen Anatomie und allgemeinen Pathologie 71: 595–618

    Google Scholar 

  • Laheij RJ, Straatman H, Jansen JB, Verbeek AL (1998) Evaluation of commercially available Helicobacter pylori serology kits: a review. J Clin Microbiol 36: 2803–2809

    PubMed  CAS  Google Scholar 

  • Lascols C, Lamarque D, Costa JM et al. (2003) Fast and accurate quantitative detection of Helicobacter pylori and identification of clarithromycin resistance mutations in H. pylori isolates from gastric biopsy specimens by real-time PCR. J Clin Microbiol 41: 4573–4577

    Article  PubMed  CAS  Google Scholar 

  • Lerang F, Haug JB, Moum B, Mowinckel P, Berge T, Ragnhildstveit E, Bjorneklett A (1998) Accuracy of IgG serology and other tests in confirming Helicobacter pylori eradication. Scand J Gastroenterol 33: 710–715

    Article  PubMed  CAS  Google Scholar 

  • Levi F, Lucchini F, Gonzalez JR, Fernandez E, Negri E, La Vecchia C (2004) Monitoring falls in gastric cancer mortality in Europe. Ann Oncol 15: 338–345

    Article  PubMed  CAS  Google Scholar 

  • Machado RS, Patricio FR, Kawakami E (2004) 13C-urea breath test to diagnose Helicobacter pylori infection in children aged up to 6 years. Helicobacter 9: 39–45

    Article  PubMed  Google Scholar 

  • Manes G, Balzano A, Iaquinto G et al. (2001) Accuracy of the stool antigen test in the diagnosis of Helicobacter pylori infection before treatment and in patients on omeprazole therapy. Aliment Pharmacol Ther 15: 73–79

    Article  PubMed  CAS  Google Scholar 

  • Matsumura M, Hikiba Y, Ogura K et al. (2001) Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium. J Clin Microbiol 39: 691–695

    Article  PubMed  CAS  Google Scholar 

  • Monteiro L, de Mascarel A, Sarrasqueta AM et al. (2001) Diagnosis of Helicobacter pylori infection: noninvasive methods compared to invasive methods and evaluation of two new tests. Am J Gastroenterol 96: 353–358

    Article  PubMed  CAS  Google Scholar 

  • Oleastro M, Menard A, Santos A, Lamouliatte H, Monteiro L, Barthelemy P, Megraud F (2003) Real-time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori. J Clin Microbiol 41: 397–402

    Article  PubMed  CAS  Google Scholar 

  • Peitz U, Leodolter A, Wex T et al. (2004) Diagnostics of Helicobacter pylori infection in patients with peptic ulcer bleeding. Z Gastroenterol 42: 141–146

    Article  PubMed  CAS  Google Scholar 

  • Perez-Perez GI, Dworkin BM, Chodos JE, Blaser MJ (1988) Campylobacter pylori antibodies in humans. Ann Intern Med 109: 11–17

    PubMed  CAS  Google Scholar 

  • Rathbone BJ, Wyatt JI, Worsley BW, Shires SE, Trejdosiewicz LK, Heatley RV, Losowsky MS (1986) Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia. Gut 27: 642–647

    PubMed  CAS  Google Scholar 

  • Suerbaum S, Michetti P (2002) Helicobacter pylori infection. N Engl J Med 347: 1175–1186

    Article  PubMed  CAS  Google Scholar 

  • Udd M, Miettinen P, Palmu A, Julkunen R (2003) Effect of short-term treatment with regular or high doses of omeprazole on the detection of Helicobacter pylori in bleeding peptic ulcer patients. Scand J Gastroenterol 38: 588–593

    Article  PubMed  CAS  Google Scholar 

  • Vaira D, Vakil N (2001) Blood, urine, stool, breath, money, and Helicobacter pylori. Gut 48: 287–289

    Article  PubMed  CAS  Google Scholar 

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Braden, B., Kist, M. (2006). Epidemiologie und Diagnostik der Helicobacter pylori-Infektion. In: Caspary, W.F., Kist, M., Stein, J. (eds) Infektiologie des Gastrointestinaltraktes. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37211-3_16

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  • DOI: https://doi.org/10.1007/3-540-37211-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41359-2

  • Online ISBN: 978-3-540-37211-0

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