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Molekulare Mikrobiologie und Immunpathogenese von Helicobacter pylori

  • Chapter
Infektiologie des Gastrointestinaltraktes

Zusammenfassung

Die Magenschleimhaut ist durch vielfältige Schutzmechanismen gegen das Eindringen von Bakterien geschützt. Helicobacter pylori (H. pylori) ist an diese ökologische Nische hochgradig adaptiert. Eine einzigartige Kombination von Virulenzfaktoren und genetischer Variabilität erlaubt es diesem Bakterium, kurze Zeit im sauren Milieu des Magenlumens zu überleben, in den hochviskösen Magenschleim einzudringen, sich dort fortzubewegen und mit Hilfe einer Chemotaxismaschinerie räumlich zu orientieren, sich mit spezialisierten Haftstrukturen an die Epithelzellen anzuheften und die Immunantwort abzuwehren bzw. partiell zu paralysieren. Hieraus resultiert eine persistierende Kolonisation der Magenschleimhaut, die über Jahrzehnte fortbestehen kann. Somit ist H. pylori das einzige pathogene Bakterium, das in seinem Wirt lebenslang extrazellulär persistieren kann, eine Eigenschaft, die sonst nur bei Bakterien der physiologischen Flora vorkommt.

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Authors and Affiliations

  1. Medizinische Klinik I, Klinikum der Johann Wolfgang, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main

    Prof. Dr. Dr. J. Stein

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  1. Prof. Dr. Dr. J. Stein
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Editors and Affiliations

  1. Zentrum der Inneren Medizin, Medizinische Klinik I des Universitätsklinikums Frankfurt/Main, Theodor-Stern-Kai 7, 60590, Frankfurt/Main

    Wolfgang F. Caspary  & Jürgen Stein  & 

  2. Abteilung für Mikrobiologie und Hygiene, Universitätsklinikum Freiburg, Hermann-Herder-Str. 11, 79104, Freiburg

    Manfred Kist

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© 2006 Springer Medizin Verlag Heidelberg

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Stein, J. (2006). Molekulare Mikrobiologie und Immunpathogenese von Helicobacter pylori. In: Caspary, W.F., Kist, M., Stein, J. (eds) Infektiologie des Gastrointestinaltraktes. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37211-3_15

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  • DOI: https://doi.org/10.1007/3-540-37211-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41359-2

  • Online ISBN: 978-3-540-37211-0

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