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In Situ Product Removal (ISPR) in Whole Cell Biotechnology During the Last Twenty Years

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Process Integration in Biochemical Engineering

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 80))

Abstract

This review sums up the activity in the field of in situ product removal in whole cell bioprocesses over the last 20 years. It gives a complete summary of ISPR operations with microbial cells and cites a series of interesting ISPR applications in plant and animal cell technology. All the ISPR projects with microbial cells are categorized according to their products, their ISPR techniques, and their applied configurations of the ISPR set-up. Research on ISPR application has primarily increased in the field of microbial production of aromas and organic acids such lactic acid over the last ten years. Apart from the field of de novo formation of bioproducts, ISPR is increasingly applied to microbial bioconversion processes. However, despite of the large number of microbial whole cell ISPR projects (approximately 250), very few processes have been transferred to an industrial scale. The proposed processes have mostly been too complex and consequently not cost effective. Therefore, this review emphasizes that the planning of a successful whole cell ISPR process should not only consider the choice of ISPR technique according to the physicochemical properties of the product, but also the potential configuration of the whole process set-up. Furthermore, additional process aspects, biological and legal constraint need to be considered from the very beginning for the design of an ISPR project. Finally, future trends of new, modified or improved ISPR techniques are given.

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  1. Laboratory of Chemical and Biochemical Engineering, Swiss Federal Institute of Technology (EPFL), 1015, Lausanne, Switzerland

    Daniel Stark & Urs von Stockar

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  1. Laboratory of Chemical and Biochemical Engineering, Swiss Federal Institute of Technology (EPFL), 1015, Lausanne, Switzerland

    Urs. von Stockar

  2. Kluyver Laboratory for Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, Netherlands

    L. A. M. van der Wielen

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Stark, D., von Stockar, U. (2003). In Situ Product Removal (ISPR) in Whole Cell Biotechnology During the Last Twenty Years. In: von Stockar, U., et al. Process Integration in Biochemical Engineering. Advances in Biochemical Engineering/Biotechnology, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36782-9_5

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