Abstract
This paper investigates the influence of the Raf Kinase In- hibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simula- tion. Using nonlinear ordinary differential equations to represent bio- chemical reactions in the pathway, we suggest a technique for parameter estimation, utilizing time series data of proteins involved in the signal- ing pathway. The mathematical model allows the simulation the sensi- tivity of the ERK pathway to variations of initial RKIP and ERK-PP (phosphorylated ERK) concentrations along with time. Throughout the simulation study, we can qualitatively validate the proposed mathemati- cal model compared with experimental results.
Corresponding authors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Yeung, K., Janosch, P., Rose, D. W., Mischak, H., Sedivy, J. M., and Kolch, W.: Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein. MOL. CELL. BIOL. 20 (2000) 3079–3085
Yeung, K, Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, C., Fee, F., Kat-sanakis, K. D., Rose, D. W., Mischak, H., Sedivy, J. M., and Kolch, W.: Sup-pression of Raf-1 kinase activity and MAP kinase signaling By RKIP. Nature. 401 (1999) 173–177
Bock, H. G.: Numerical treatment of inverse problems in chemical reaction kinetics. Modeling of Chemical Reaction Systems. 18 (1981) 102–125
Hegger, R., Kantz, H., Schmuser, F., Diestelhorst, M., Kapsch, R. P., and Beige, H.: Dynamical properties of a ferroelectric capccitor observed through nonlinear time series analysis. Chaos. 8 (1998) 727–736
Hegger, R., Kantz, H., Schmuser, F., Diestelhorst, M., Kapsch, R. P., and Beige, H.: Dynamical properties of a ferroelectric capccitor observed through nonlinear time series analysis. Chaos. 8 (1998) 727–736
Voit, E. O., Computational Analysis of Biochemical Systems, Cambridge Uni-versity Press: Cambridge, U.K., 2000
Marshall, C. J., Specificity of receptor tyrosine kinase signaling: transient ver-sus sustained extracellular signal-regulated kinase activation: Cell. 80 (1995) 179–185
Zhou, B., Wang, Z. X., Zhao, Y., Brautigan, D. L., and Zhang, Z. Y.:The speci-ficity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphotases. J Biol Chem. 277 (2002) 31818–31825
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Kwang-Hyun, C., Sung-Young, S., Hyun-Woo, K., Wolkenhauer, O., McFerran, B., Kolch, W. (2003). Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway. In: Priami, C. (eds) Computational Methods in Systems Biology. CMSB 2003. Lecture Notes in Computer Science, vol 2602. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-36481-1_11
Download citation
DOI: https://doi.org/10.1007/3-540-36481-1_11
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00605-3
Online ISBN: 978-3-540-36481-8
eBook Packages: Springer Book Archive