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Enantioselective Synthesis by Lithiation to Generate Planar or Axial Chirality

  • Jonathan Clayden
Chapter
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 5)

Abstract

Enantioselective lithiation can be used to introduce and control new elements of planar or of axial chirality. The principal classes of compounds displaying these stereochemical features are ferrocenes, arenechromium tricarbonyl complexes, biaryls, atropisomeric amides and allenes. Methods for the enantioselective lithiation of these compound classes, relying on either substrate (chiral auxiliary) or reagent (chiral base) control will be reviewed.

Keywords

Ferrocenes Arenechromium tricarbonyls Atropisomers Chiral lithium amides (-)-Sparteine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Jonathan Clayden
    • 1
  1. 1.Department of ChemistryUniversity of ManchesterManchesterUK

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